Soluble ACE2-mediated cell entry of SARS-CoV-2 (Homo sapiens)

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1SARS-CoV-2Receptor-mediated endocytosisVasopressinADAM17AGTR1sACE2AVPR1BACE2S1S1SARS-CoV-2sACE2SARS-CoV-2S1VasopressinS1SARS-CoV-2sACE2S1SARS-CoV-2sACE2VasopressinsACE2SARS-CoV-2S1Receptor-mediated endocytosis


ACE2 is a regulator of the renin-angiotensin system. To perform this function, ACE2 is transported to the cell surface, where it is cleaved by disintegrin and ADAM17 to produce an enzymatically active soluble form of ACE2. This soluble form retains the SARS-CoV-2 binding site. SARS-CoV-2 bound to either soluble ACE2 or soluble ACE2 and vasopressin then uses receptor-mediated endocytosis by through either AT1 or AVPR1B, respectively. This figure is based on the graphical abstract from Yeung et al..

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  1. Yeung ML, Teng JLL, Jia L, Zhang C, Huang C, Cai JP, Zhou R, Chan KH, Zhao H, Zhu L, Siu KL, Fung SY, Yung S, Chan TM, To KK, Chan JF, Cai Z, Lau SKP, Chen Z, Jin DY, Woo PCY, Yuen KY; ''Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.''; Cell, 2021 PubMed Europe PMC Scholia


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118892view12:35, 3 June 2021EweitzOntology Term : 'endocytosis pathway' added !
118891view12:34, 3 June 2021EweitzOntology Term : 'COVID-19' added !
116048view16:29, 2 April 2021Khanspersadded lit ref and switched generic sheddase node for AFDAM17
116047view16:23, 2 April 2021KhanspersModified description
116042view19:56, 1 April 2021Khansperswork in progress
116041view19:05, 1 April 2021KhanspersOntology Term : 'severe acute respiratory syndrome' added !
116040view19:05, 1 April 2021KhanspersOntology Term : 'viral infectious disease' added !
116039view18:54, 1 April 2021KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
ACE2GeneProductENSG00000130234 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
AGTR1GeneProductENSG00000144891 (Ensembl)
AVPR1BGeneProductENSG00000198049 (Ensembl)
S1ProteinQ106020256 (Wikidata)
VasopressinMetaboliteHMDB01980 (HMDB)
sACE2GeneProductENSG00000130234 (Ensembl)

Annotated Interactions

No annotated interactions

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