Modulators of TCR signaling and T cell activation (Homo sapiens)

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1, 2NucleusCytokine receptorMAP4K1CD5DAGLCP2PTRB BETACBLBNFKB1RELARELPPPCHUKPIKBKBPNFKBIAPLCKPCD247CARD11ITKPPRKCQPCD247PSH2B3CD3EGRAP2GRB2PCD3DCD3EPLCG1PCD3GMALT1BCL10UbPVAV1PPIK3R2LATPPIK3R1TRA ALPHACD8AZAP70PCD28AKT1PDPK1MAP3K14MAP3K8IKBKGTRAF6TMEM222GNA13PTPN6SOCS1CUL5RNF7UBASH3AFIBPRASA2DGKZDGKATCEB2TNFAIP3SMARCB1CDKN1BZFP36L1RPRD1BPCBP2ARIH2MEF2DAGO1RHOHSH2D1ANDUFB10


Description

Modulators of TCR signaling and T cell activation from a genome-wide screen, with positive regulators on the left and negative regulators on the right (known and unknown). Adapted from figure 2F from Shifrut et al., and originally adapted from NetPath.

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Ontology Terms

 

Bibliography

  1. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A; ''Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.''; Cell, 2018 PubMed Europe PMC Scholia
  2. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115764view00:17, 11 March 2021Khanspersupdated interaction and added receptor glyph
115754view21:38, 9 March 2021Khanspersupdated label for TCEB2 node
115720view23:37, 8 March 2021KhanspersModified description
115719view23:26, 8 March 2021KhanspersModified description
115718view23:11, 8 March 2021KhanspersOntology Term : 'signaling pathway' added !
115717view23:10, 8 March 2021Khanspersdecreased board height
115716view23:09, 8 March 2021Khanspersdecreased board height
115715view23:08, 8 March 2021Khanspersremoved erroneous object
115714view23:07, 8 March 2021Khanspersadded literature references
115713view23:03, 8 March 2021KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AGO1GeneProductENSG00000092847 (Ensembl)
AKT1ProteinENSG00000142208 (Ensembl)
ARIH2GeneProductENSG00000177479 (Ensembl)
BCL10ProteinENSG00000142867 (Ensembl)
CARD11ProteinENSG00000198286 (Ensembl)
CBLBProtein868 (Entrez Gene)
CD247ProteinENSG00000198821 (Ensembl)
CD28ProteinENSG00000178562 (Ensembl)
CD3DProteinENSG00000167286 (Ensembl)
CD3EProtein916 (Entrez Gene)
CD3EProteinENSG00000198851 (Ensembl)
CD3GProteinENSG00000160654 (Ensembl)
CD5GeneProductENSG00000110448 (Ensembl)
CD8AProteinENSG00000153563 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CHUKProteinENSG00000213341 (Ensembl)
CUL5GeneProductENSG00000166266 (Ensembl)
DAGMetabolite18035 (ChEBI)
DGKAGeneProductENSG00000065357 (Ensembl)
DGKZGeneProductENSG00000149091 (Ensembl)
FIBPGeneProductENSG00000172500 (Ensembl)
GNA13GeneProductENSG00000120063 (Ensembl)
GRAP2ProteinENSG00000100351 (Ensembl)
GRB2ProteinENSG00000177885 (Ensembl)
IKBKBProteinENSG00000104365 (Ensembl)
IKBKGProteinENSG00000269335 (Ensembl)
ITKProteinENSG00000113263 (Ensembl)
LATProteinENSG00000213658 (Ensembl)
LCKProteinENSG00000182866 (Ensembl)
LCP2ProteinENSG00000043462 (Ensembl)
MALT1ProteinENSG00000172175 (Ensembl)
MAP3K14ProteinENSG00000006062 (Ensembl)
MAP3K8ProteinENSG00000107968 (Ensembl)
MAP4K1ProteinENSG00000104814 (Ensembl)
MEF2DGeneProductENSG00000116604 (Ensembl)
NDUFB10GeneProductENSG00000140990 (Ensembl)
NFKB1ProteinENSG00000109320 (Ensembl)
NFKBIAProteinENSG00000100906 (Ensembl)
PCBP2GeneProductENSG00000197111 (Ensembl)
PDPK1ProteinENSG00000140992 (Ensembl)
PIK3R1ProteinENSG00000145675 (Ensembl)
PIK3R2ProteinENSG00000105647 (Ensembl)
PLCG1ProteinENSG00000124181 (Ensembl)
PRKCQProteinENSG00000065675 (Ensembl)
PTPN6GeneProductENSG00000111679 (Ensembl)
RASA2GeneProductENSG00000155903 (Ensembl)
RELAProteinENSG00000173039 (Ensembl)
RELProteinENSG00000162924 (Ensembl)
RHOHGeneProductENSG00000168421 (Ensembl)
RNF7GeneProductENSG00000114125 (Ensembl)
RPRD1BGeneProductENSG00000101413 (Ensembl)
SH2B3ProteinENSG00000111252 (Ensembl)
SH2D1AGeneProductENSG00000183918 (Ensembl)
SMARCB1GeneProductENSG00000099956 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
TCEB2GeneProductENSG00000103363 (Ensembl)
TMEM222GeneProductENSG00000186501 (Ensembl)
TNFAIP3GeneProductENSG00000118503 (Ensembl)
TRA ALPHAProtein6955 (Entrez Gene)
TRAF6ProteinENSG00000175104 (Ensembl)
TRB BETAProtein6957 (Entrez Gene)
UBASH3AGeneProductENSG00000160185 (Ensembl)
VAV1ProteinENSG00000141968 (Ensembl)
ZAP70ProteinENSG00000115085 (Ensembl)
ZFP36L1GeneProductENSG00000185650 (Ensembl)

Annotated Interactions

No annotated interactions

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