PPAR-gamma pathway (Homo sapiens)

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1, 2RELACD36ADIPOQFABP4PTGS2CREBBPNFKB1CEBPACEBPBRXRALPLNCOA1EP300CEBPGPCK2PLIN2PCK1IL1ATNFPPARGCEBPDRXRBRXRGRXRAPPARGRELIL1BRXRBRXRG


Description

The Peroxisome Proliferator-Activated Receptor Gamma forms a heterodimer with retinoid X receptors which regulates gene expression of various genes. This pathway is based on the entry on the PPARG pathway on Nuclear Receptor Resource (https://nrresource.org/nuclear_receptors/peroxisome-proliferator-activated-receptor-gamma-pparg-nr1c3/).

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Ontology Terms

 

Bibliography

  1. Ali AT, Hochfeld WE, Myburgh R, Pepper MS; ''Adipocyte and adipogenesis.''; Eur J Cell Biol, 2013 PubMed Europe PMC Scholia
  2. Skat-Rørdam J, Højland Ipsen D, Lykkesfeldt J, Tveden-Nyborg P; ''A role of peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease.''; Basic Clin Pharmacol Toxicol, 2019 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116510view10:45, 7 May 2021EweitzModified title
115994view15:07, 27 March 2021Jkearns445Fixed an interaction
115712view21:13, 8 March 2021Marvin M2Ontology Term : 'signaling pathway' added !
115711view21:12, 8 March 2021Marvin M2Ontology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
115710view21:12, 8 March 2021Marvin M2Modified description
115709view21:10, 8 March 2021Marvin M2Additional target genes and literature references added
115708view21:01, 8 March 2021Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADIPOQGeneProductADIPOQ (HGNC)
CD36GeneProductENSG00000135218 (Ensembl)
CEBPAGeneProductCEBPA (HGNC)
CEBPBGeneProductCEBPB (HGNC)
CEBPDGeneProductCEBPD (HGNC)
CEBPGGeneProductCEBPG (HGNC)
CREBBPGeneProductENSG00000005339 (Ensembl)
EP300GeneProductEP300 (HGNC)
FABP4GeneProductENSG00000170323 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
LPLGeneProductLPL (HGNC)
NCOA1GeneProductENSG00000084676 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PCK1GeneProductENSG00000124253 (Ensembl)
PCK2GeneProductENSG00000100889 (Ensembl)
PLIN2GeneProductENSG00000147872 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RELGeneProductENSG00000162924 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
TNFGeneProductTNF (HGNC)

Annotated Interactions

No annotated interactions

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