SARS-CoV-2 altering angiogenesis via NRP1 (Homo sapiens)

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41Host cellSARS-CoV-2Surface glycoprotein SMembrane fusionKDRFURINAngiogenesisVEGFAACE2S2S1NRP1NRP12, 5, 62-4


Mechanism of how the SARS-cov-2 virus is involved in altering angiogenesis and how NRP1 might play a role as an entry factor for the virus.

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  1. Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, Stratton HJ, Cai S, Luo S, Gonzalez KB, Perez-Miller S, Patwardhan A, Ibrahim MM, Khanna R; ''SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia.''; bioRxiv, 2020 PubMed Europe PMC Scholia
  2. Mayi BS, Leibowitz JA, Woods AT, Ammon KA, Liu AE, Raja A; ''The role of Neuropilin-1 in COVID-19.''; PLoS Pathog, 2021 PubMed Europe PMC Scholia
  3. McFarland AJ, Yousuf MS, Shiers S, Price TJ; ''Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain.''; Pain Rep, 2021 PubMed Europe PMC Scholia
  4. Li ZL, Buck M; ''Neuropilin-1 Assists SARS-CoV-2 Infection by Stimulating the Separation of Spike Protein Domains S1 and S2.''; bioRxiv, 2021 PubMed Europe PMC Scholia
  5. Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, Shoemark DK, Simón-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi Y; ''Neuropilin-1 is a host factor for SARS-CoV-2 infection.''; Science, 2020 PubMed Europe PMC Scholia
  6. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M; ''Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.''; Cell, 1998 PubMed Europe PMC Scholia


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118890view12:13, 3 June 2021EweitzOntology Term : 'COVID-19' added !
116010view07:21, 29 March 2021LenaszaboModified description
115862view16:02, 18 March 2021FehrhartModified title
115861view16:01, 18 March 2021FehrhartOntology Term : 'severe acute respiratory syndrome' added !
115860view16:01, 18 March 2021FehrhartOntology Term : 'disease pathway' added !
115859view16:00, 18 March 2021Fehrhartsmall graphical adaptions
115835view14:32, 18 March 2021Fehrhartadded IDs for S1 and S2
115598view12:07, 1 March 2021SVossenModified title
115597view12:05, 1 March 2021SVossenNew pathway

External references


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NameTypeDatabase referenceComment
ACE2GeneProductENSG00000130234 (Ensembl)
AngiogenesisPathwayWP1993 (WikiPathways)
FURINGeneProductENSG00000140564 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl)
Membrane fusionPathwayQ6556360 (Wikidata)
NRP1GeneProductENSG00000099250 (Ensembl)
S1ProteinQ106020256 (Wikidata)
S2ProteinQ106020384 (Wikidata)
Surface glycoprotein SProteinP0DTC2 (Uniprot-TrEMBL)
VEGFAGeneProductENSG00000112715 (Ensembl)

Annotated Interactions

No annotated interactions

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