FOXP3 in COVID-19 (Homo sapiens)

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2264, 531, 474, 59CD4+ T-cellNo specific interaction yetAntigen presenting cellCD86TCRIL6RCD80CD28IL6STMHC-II alphaMHC-II betaIL2RBFOXP3IL2RAFOXP3IL6STAT3IL7RIL2RGMildSevereHyperactivated T cellRegulatory T cellIL2STAT5ASTAT5BIL2IL7RIL2RBIL2RAIL2RGFOXP3FOXP3STAT3STAT5ASTAT5BIL6STIL6RIL6810


FOXP3 in Covid-19

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  1. S Hori, T Nomura, S Sakaguchi; ''Control of regulatory T cell development by the transcription factor Foxp3 ''; Science, 2003 PubMed Europe PMC Scholia
  2. A Shimizu, S Kondo, H Sabe, N Ishida, T Honjo; ''Structure and function of the interleukin 2 receptor: affinity conversion model''; Immunological reviews, 1986 PubMed Europe PMC Scholia
  3. E Bettelli, Y Carrier, W Gao, T Korn, TB Strom, M Oukka, HL Weiner, VK Kuchroo; ''Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells ''; Nature, 2006 PubMed Europe PMC Scholia
  4. M Ono, RJ Tanaka; ''Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective''; Immunology & Cell biology, 2016 PubMed Europe PMC Scholia
  5. K Freudenberg, N Lindner, S Dohnke, AI Garbe, S Schallenberg, K Kretschmer; ''Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation ''; Frontiers in Immunology, 2018 PubMed Europe PMC Scholia
  6. D Bending, M Ono; ''From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics ''; Clinical and experimental immunology, 2019 PubMed Europe PMC Scholia
  7. C Orabona, U Grohmann, ML Belladonna, F Fallarino, G Vacca, R Bianchi, S Bozza, C Volpi, BL Salomon, MC Fioretti, L Romani, P Pucetti; ''CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86''; Nature immunology, 2004 PubMed Europe PMC Scholia
  8. B Kalfaoglu, J Almeida-Santos, CA Tye, Y Satou, M Ono; ''T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis ''; Frontiers in Immunology, 2020 PubMed Europe PMC Scholia
  9. C Huang, Y Wang, X Li, L Ren, J Zhao, Y Hu, L Zhang, G Fan, J Xu, X Gu, Z Cheng, T Yu, J Xia, Y Wei, W Wu, X Xie, W Yin, H Li, M Liu, Y Xiao, H Gao, L Guo, J Xie, G Wang, R Jiang, Z Gao, Q Jin, J Wang, B Cao; ''Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China''; Lancet, 2020 PubMed Europe PMC Scholia
  10. H Shi, W Wang, J Yin, Y Ouyang, L Pang, Y Feng, L Qiao, X Guo, H Shi, R Jin, D Chen; ''The inhibition of IL-2/IL-2R gives rise to CD8 + T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia ''; Cell death and disease, 2020 PubMed Europe PMC Scholia


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118833view09:12, 2 June 2021EweitzOntology Term : 'T cell' added !
118832view09:12, 2 June 2021EweitzOntology Term : 'COVID-19' added !
118831view09:11, 2 June 2021EweitzOntology Term : 'DOID:2945' removed !
115865view16:10, 18 March 2021Fehrhartgraphical adjustments
115704view08:10, 8 March 2021Fehrhartconnected unconnected line
115618view18:29, 1 March 2021IljadwRemoved unconnected lines
115574view06:03, 27 February 2021MaintBotOntology Term : 'severe acute respiratory syndrome' added !
115573view06:02, 27 February 2021MaintBotOntology Term : 'disease pathway' added !
115553view16:23, 26 February 2021IljadwModified title
115551view16:21, 26 February 2021IljadwNew pathway

External references


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NameTypeDatabase referenceComment
CD28ProteinP10747 (Uniprot-TrEMBL)
CD80ProteinP33681 (Uniprot-TrEMBL)
CD86ProteinP42081 (Uniprot-TrEMBL)
FOXP3ProteinB7ZLG1 (Uniprot-TrEMBL)
FOXP3GeneProductENSG00000049768 (Ensembl)
IL2GeneProductIL2 (HGNC)
IL2RAGeneProductIL2RA (HGNC)
IL2RBGeneProductIL2RB (HGNC)
IL2RGGeneProductIL2RG (HGNC)
IL6GeneProductIL6 (HGNC)
IL6RGeneProductIL6R (HGNC)
IL6STGeneProductIL6ST (HGNC)
IL7RGeneProductIL7R (HGNC)
MHC-II alpha ComplexPF00993 (Pfam)
MHC-II betaProteinPF00969 (Pfam)
STAT3GeneProductSTAT3 (HGNC)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)

Annotated Interactions

No annotated interactions

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