Burn wound healing (Homo sapiens)

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Upregulated GenesLPS15, 25PGE215PGS23EGF21GROA31hsa-miR-4485-3p36CXCL1440TPM37VIM7PFN17SPARC7TLR415, 49IL815, 22, 40IL615, 40CCL215MYD8815hsa-miR-181b3PGS23ACHA720ACES20hsa-miR-29a28, 37GAS537HCP537MIAT37LINC0033837LN28A37hsa-miR-29b-3p38XIST37, 38hsa-miR-12651SCEL51VEGFA16, 28, 51COL1A228, 51MMP933, 51HOTAIR51TGFB243CNN243TGFB343FST11COL1A16, 11, 13, 37, 38INHBA11AKT1P1147CXCR422, 25CXCL1222, 25SMAD3P42BRD442FN140, 42Col1A142NOX442TAGLN42IFNA216, 25, 50KLF42MIR1452BCL234, 35SFRP235SNAI235IFNB117KDR1713PECAM144ACTA14, 10, 11, 23, 24, 37...SERPINH144NFKB144TGFB13, 11, 21, 24, 26...IL1B40, 44MIR29B144TNF44COL1A144MIR29B144MMP136FBN19TNC9ELN9ICAM145CXCR231TAGL40IL1A40TNFAIP340NFKBIZ40NFKBIA40ADAM1240FOXE140CD24840FILA1K2C6A1MMP2827MMP133MMP333TIMP133TIMP233MMP233TLR115TLR215TLR315TLR515TLR615TLR715TLR815TLR915NOD115NOD215LY9615S10A629S10A929S10AB29SLUR120ACh20HMGB120CASP320SFRP253SNAI253PECAM116SERPINH113bsmA 4F13A14FGFR146FGFR246FGFR346FGFR446CD3E52IL155Col1a1b6HGF18CXCR422Cspg410PDGFRb10Krt22210TP5332Activin12Sulfate30HEXD8AMBP30Sequencing DataDownregulated GenesUp-& Down-regulated GenesNOTCH219, 48MMP719, 48JAG219, 48LGLAS1HULC4149MIR663BMMP14949TIMP149TPT134BAX34CASP334CDK1634hsa-miR-324-5p49


Description

This pathway is part of a systematic review on currently known molecular players in burn wound healing in mammalians.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
122621view08:42, 22 April 2022ExperiMeddeleted a wrong node
122620view08:41, 22 April 2022ExperiMedupdated/added nodes, edges and references
120278view13:44, 23 November 2021EgonwClean up of two references
119583view07:17, 21 July 2021ExperiMedModified description
119552view10:47, 15 July 2021ExperiMedOntology Term : 'immune response pathway' added !
119551view10:47, 15 July 2021ExperiMedOntology Term : 'keratinocyte' added !
119550view10:46, 15 July 2021ExperiMedOntology Term : 'endothelial cell' added !
119549view10:46, 15 July 2021ExperiMedOntology Term : 'myofibroblast cell' added !
119548view10:46, 15 July 2021ExperiMedOntology Term : 'fibroblast' added !
119547view10:28, 15 July 2021ExperiMedOntology Term : 'cell-extracellular matrix signaling pathway' added !
119546view10:19, 15 July 2021ExperiMedFixed Interaction
117667view11:58, 22 May 2021EweitzModified title
116240view17:07, 21 April 2021EgonwUse Uniprot-TrEMBL instead of Uniprot-SwissProt
115827view23:10, 15 March 2021Khanspersminor change to trigger update
115639view10:08, 3 March 2021ExperiMedadded full references
115373view16:29, 16 February 2021ExperiMedNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACESProteinP22303 (Uniprot-TrEMBL)
ACHA7ProteinP36544 (Uniprot-TrEMBL)
ACTA1ProteinP68133 (Uniprot-TrEMBL)
AChMetaboliteHMDB0000895 (HMDB)
ADAM12RnaENSG00000148848 (Ensembl) pericytes
AKT1ProteinP31749 (Uniprot-TrEMBL)
AMBPProteinP02760 (Uniprot-TrEMBL)
  • Uronic acid
  • Type your comment here
ActivinProtein
  • Fibroblasts, Histiocytes, Endothelial cells, Lymphocytes
  • Type your comment here
BAXProteinQ07812 (Uniprot-TrEMBL)
BCL2ProteinP10415 (Uniprot-TrEMBL)
BRD4ProteinO60885 (Uniprot-TrEMBL)
CASP3ProteinP42574 (Uniprot-TrEMBL)
CCL2ProteinP13500 (Uniprot-TrEMBL) pericytes
CD248RnaENSG00000174807 (Ensembl) pericytes
CD3EProteinP07766 (Uniprot-TrEMBL)
  • Fibroblasts
  • Type your comment here
CDK16ProteinQ00536 (Uniprot-TrEMBL)
CNN2RnaENSG00000064666 (Ensembl)
COL1A1ProteinP02452 (Uniprot-TrEMBL)
COL1A2ProteinP08123 (Uniprot-TrEMBL)
CXCL12ProteinP48061 (Uniprot-TrEMBL)
  • SDF1
  • Type your comment here
CXCL14RnaENSG00000145824 (Ensembl) pericytes
CXCR2ProteinP25025 (Uniprot-TrEMBL)
CXCR4ProteinP61073 (Uniprot-TrEMBL)
  • Fibroblasts
  • Type your comment here
Col1A1RnaENSG00000108821 (Ensembl)
Col1a1bRnaENSDARG00000035809 (Ensembl)
  • Fibroblasts
  • Type your comment here
Cspg4ProteinQ8VHY0 (Uniprot-TrEMBL)
EGFProteinP01133 (Uniprot-TrEMBL)
ELNProteinP15502 (Uniprot-TrEMBL)
F13A1ProteinP00488 (Uniprot-TrEMBL)
FBN1ProteinP35555 (Uniprot-TrEMBL)
FGFR1ProteinP11362 (Uniprot-TrEMBL)
FGFR2ProteinP21802 (Uniprot-TrEMBL)
FGFR3ProteinP22607 (Uniprot-TrEMBL)
FGFR4ProteinP22455 (Uniprot-TrEMBL)
FILAProteinP20930 (Uniprot-TrEMBL) pericytes
FN1RnaENSG00000115414 (Ensembl)
FOXE1ProteinO00358 (Uniprot-TrEMBL) pericytes
FSTGeneProductP19883 (Uniprot-TrEMBL)
GAS5RnaENSG00000234741 (Ensembl) pericytes
GROAProteinP09341 (Uniprot-TrEMBL)
HCP5RnaENSG00000237105 (Ensembl) pericytes
HEXDProteinQ8WVB3 (Uniprot-TrEMBL)
HGFProteinP14210 (Uniprot-TrEMBL)
HMGB1ProteinP09429 (Uniprot-TrEMBL)
HOTAIRRnaENSG00000228630 (Ensembl) pericytes
HULCRnaENSG00000285219 (Ensembl)
ICAM1ProteinP05362 (Uniprot-TrEMBL)
IFNA2ProteinP01563 (Uniprot-TrEMBL)
IFNB1ProteinP01574 (Uniprot-TrEMBL)
IL15ProteinP40933 (Uniprot-TrEMBL)
  • Fibroblasts
  • Type your comment here
IL1ARnaENSG00000115008 (Ensembl) pericytes
IL1BProteinP01584 (Uniprot-TrEMBL)
IL6ProteinP05231 (Uniprot-TrEMBL) pericytes
IL8ProteinP10145 (Uniprot-TrEMBL) pericytes
INHBAProteinP08476 (Uniprot-TrEMBL)
  • = Activin A = EDF
  • Type your comment here
JAG2ProteinP97607 (Uniprot-TrEMBL)
K2C6AProteinP02538 (Uniprot-TrEMBL) pericytes
KDRRnaENSG00000128052 (Ensembl)
  • VEGFR2
  • Type your comment here
KLF4ProteinO43474 (Uniprot-TrEMBL)
Krt222ProteinQ8N1A0 (Uniprot-TrEMBL)
LGLAS1ProteinP09382 (Uniprot-TrEMBL)
LINC00338RnaENSG00000234912 (Ensembl) pericytes
LN28AProteinQ9H9Z2 (Uniprot-TrEMBL)
LPSMetabolite53481794 (PubChem-substance)
LY96RnaENSG00000154589 (Ensembl) pericytes
MIATRnaENSG00000225783 (Ensembl) pericytes
MIR145RnaENSG00000276365 (Ensembl)
MIR29B1ProteinENSG00000283797 (Ensembl)
MIR663BRnaENSG00000221288 (Ensembl)
MMP13RnaENSG00000137745 (Ensembl)
  • Fibroblasts
  • Type your comment here
MMP1RnaENSG00000196611 (Ensembl) pericytes
MMP1ProteinP03956 (Uniprot-TrEMBL)
MMP28ProteinQ9H239 (Uniprot-TrEMBL) pericytes
MMP2ProteinP08253 (Uniprot-TrEMBL) pericytes
MMP3RnaENSG00000149968 (Ensembl) pericytes
MMP7ProteinP50280 (Uniprot-TrEMBL)
MMP9ProteinP14780 (Uniprot-TrEMBL)
MYD88ProteinQ99836 (Uniprot-TrEMBL) pericytes
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NFKBIARnaENSG00000100906 (Ensembl) pericytes
NFKBIZRnaENSG00000144802 (Ensembl) pericytes
NOD1RnaENSG00000106100 (Ensembl) pericytes
NOD2RnaENSG00000167207 (Ensembl) pericytes
NOTCH2ProteinQ9QW30 (Uniprot-TrEMBL)
NOX4ProteinQ9NPH5 (Uniprot-TrEMBL)
PDGFRbProteinP09619 (Uniprot-TrEMBL)
PECAM1ProteinP16284 (Uniprot-TrEMBL)
PFN1RnaENSG00000108518 (Ensembl) pericytes
PGE2MetaboliteHMDB0060041 (HMDB)
PGS2ProteinP07585 (Uniprot-TrEMBL)
S10A6ProteinP06703 (Uniprot-TrEMBL)
S10A9ProteinP06702 (Uniprot-TrEMBL)
S10ABProteinP31949 (Uniprot-TrEMBL)
SCELProteinO95171 (Uniprot-TrEMBL)
SERPINH1ProteinP50454 (Uniprot-TrEMBL) HSP47
SFRP2ProteinQ96HF1 (Uniprot-TrEMBL)
  • Fibroblasts
  • Type your comment here
SLUR1ProteinP55000 (Uniprot-TrEMBL)
SMAD3ProteinP84022 (Uniprot-TrEMBL)
SNAI2ProteinO43623 (Uniprot-TrEMBL)
  • Fibroblasts
  • Type your comment here
SPARCRnaENSG00000113140 (Ensembl) pericytes
SulfateMetaboliteHMDB0001448 (HMDB)
TAGLNRnaENSG00000149591 (Ensembl)
TAGLProteinQ01995 (Uniprot-TrEMBL) pericytes
TGFB1ProteinP01137 (Uniprot-TrEMBL)
TGFB2ProteinP61812 (Uniprot-TrEMBL)
TGFB3ProteinP10600 (Uniprot-TrEMBL)
TIMP1RnaENSG00000102265 (Ensembl) pericytes
TIMP1ProteinP01033 (Uniprot-TrEMBL)
TIMP2RnaENSG00000035862 (Ensembl) pericytes
TLR1RnaENSG00000174125 (Ensembl) pericytes
TLR2RnaENSG00000137462 (Ensembl) pericytes
TLR3RnaENSG00000164342 (Ensembl) pericytes
TLR4ProteinO00206 (Uniprot-TrEMBL) pericytes
TLR5RnaENSG00000187554 (Ensembl) pericytes
TLR6RnaENSG00000174130 (Ensembl) pericytes
TLR7RnaENSG00000196664 (Ensembl) pericytes
TLR8RnaENSG00000101916 (Ensembl) pericytes
TLR9RnaENSG00000239732 (Ensembl) pericytes
TNCProteinP24821 (Uniprot-TrEMBL)
TNFAIP3RnaENSG00000118503 (Ensembl) pericytes
TNFProteinP01375 (Uniprot-TrEMBL)
TP53ProteinP04637 (Uniprot-TrEMBL)
TPM3RnaENSG00000174807 (Ensembl) pericytes
TPT1ProteinP13693 (Uniprot-TrEMBL)
VEGFAProteinP15692 (Uniprot-TrEMBL)
VIMRnaENSG00000026025 (Ensembl) pericytes
XISTRnaENSG00000229807 (Ensembl) pericytes
bsmA ProteinP39297 (Uniprot-TrEMBL)
hsa-miR-126RnaMI0000471 (miRBase Sequence)
hsa-miR-181bRnaMI0003331 (miRBase Sequence)
hsa-miR-29aRnaMI0000087 (miRBase Sequence)
hsa-miR-29b-3pRnaMIMAT0000100 (miRBase Sequence)
hsa-miR-324-5pRnaMIMAT0000761 (miRBase Sequence)
hsa-miR-4485-3pRnaMI0016846 (miRBase Sequence)

Annotated Interactions

No annotated interactions

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