Nephrogenesis (Homo sapiens)

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121. Induction of pretubular aggregate3. Epithelialized Renal VesiclePretubular aggregatefrom ureteric bud4. Comma Shaped StageNephron progenitor cellStromal progenitor2. Primed nephron progenitorFOXD1RSPO3JAG1TCF21SIX2WNT4PAX2BMP7MEIS1GREB1LALDH1A2FGF8WNT3AFGF20OSR1LHX1RSPO1WNT9B NOTCH2


This pathway describes the gene signalling pathways active in early nephrogenesis in human development. Mutations in essential genes can lead to development of CAKUT (congenital anomalies of the kidney and urinary tract).

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Ontology Terms



  1. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R; ''Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.''; Development, 2007 PubMed Europe PMC Scholia
  2. Vivante A, Mark-Danieli M, Davidovits M, Harari-Steinberg O, Omer D, Gnatek Y, Cleper R, Landau D, Kovalski Y, Weissman I, Eisenstein I, Soudack M, Wolf HR, Issler N, Lotan D, Anikster Y, Dekel B; ''Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling.''; J Am Soc Nephrol, 2013 PubMed Europe PMC Scholia


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118777view15:58, 1 June 2021FehrhartOntology Term : 'CAKUT' added !
118775view15:56, 1 June 2021Fehrhartadded WNT4 interaction with WNT3A
115258view09:18, 8 February 2021FehrhartModified description
115255view09:02, 8 February 2021FehrhartOntology Term : 'kidney disease' added !
115254view09:02, 8 February 2021FehrhartOntology Term : 'Notch signaling pathway' added !
115253view09:01, 8 February 2021FehrhartOntology Term : 'signaling pathway' added !
115249view08:47, 8 February 2021FehrhartNew pathway

External references


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NameTypeDatabase referenceComment
ALDH1A2GeneProductENSG00000128918 (Ensembl)
BMP7GeneProductENSG00000101144 (Ensembl)
FGF20GeneProductENSG00000078579 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FOXD1GeneProductENSG00000251493 (Ensembl)
GREB1LGeneProductENSG00000141449 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
LHX1GeneProductENSG00000274577 (Ensembl)
MEIS1GeneProductENSG00000143995 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
OSR1GeneProductENSG00000143867 (Ensembl)
PAX2GeneProductENSG00000075891 (Ensembl)
RSPO1GeneProductENSG00000169218 (Ensembl)
RSPO3GeneProductENSG00000146374 (Ensembl)
SIX2GeneProductENSG00000170577 (Ensembl)
TCF21GeneProductENSG00000118526 (Ensembl)
WNT3AGeneProductENSG00000154342 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WNT9B GeneProductENSG00000158955 (Ensembl)

Annotated Interactions

No annotated interactions

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