TGF Beta Signaling Pathway (Rattus norvegicus)

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1, 2Cofactorsligands:RsmadsCo-smadsAccessory receptors:TGFbCofactorCo-SmadsRepressorsR-SmadsSmad9Zfyve9Tgfbr3Tgfbr1Smad4Tgfbr1Bmp4Jak1Runx2Tgfbr2Ltbp1InhbaStat1Mapk3Itgb6Tgif1Zeb2Smad7SKIRunx3JunLef1Smad1Serpine1HrasSmad2NogSmad2Stat3Mapk9Foxh1Zfp423BambiTgfb1TnfSmad6EgfFosTcfe3THBS1Nfkb1Wnt1Ep300SkilTnfBmp4Tgfb1FstCtnnb1CrebbpSmad3ENGSpp1LifTgfbr2Smad1IfngSmad5Fkbp1a


The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.


GenMAPP remarks 
edited by: Nathan Salomonis
This pathway was inferred from Homo sapiens pathway WP560(r30273) with a 94% conversion rate.

Quality Tags

Ontology Terms



  1. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  2. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC Scholia


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109396view16:12, 16 March 2020L DupuisFixed interactions
69331view18:50, 8 July 2013MaintBotUpdated to 2013 gpml schema
67694view11:50, 26 June 2013DdiglesOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
41642view02:33, 2 March 2011MaintBotRemoved redundant pathway information and comments
34045view19:00, 9 December 2009MaintBotAutomatic update of empty xrefs
32127view13:54, 14 August 2009MaintBotFixed group labels
30991view00:56, 30 July 2009MaintBotConverted from Homo sapiens
21740view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:TGF Beta Signaling Pathway]] moved to [[Pathway:WP505]]: Moved to stable identifier
8444view13:46, 7 January 2008MaintBot[[Pathway:Rat:TGF Beta Signaling Pathway]] moved to [[Pathway:Rattus norvegicus:TGF Beta Signaling Pathway]]: Renaming species
7838view16:21, 18 December 2007MaintBotfixed category names
7303view12:42, 4 November 2007MaintBotAdded categories to GPML
19552view22:20, 22 May 2007M.Ramirezgpml file for [[Rat:TGF_Beta_Signaling_Pathway]]
6602view22:20, 22 May 2007N.Galgpml file for [[Rat:TGF_Beta_Signaling_Pathway]]

External references


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NameTypeDatabase referenceComment
BambiGeneProduct83837 (Entrez Gene)
Bmp4GeneProduct25296 (Entrez Gene)
CrebbpGeneProduct54244 (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
ENGGeneProduct497010 (Entrez Gene)
EgfGeneProduct25313 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
Fkbp1aGeneProduct25639 (Entrez Gene)
FosGeneProduct314322 (Entrez Gene)
Foxh1GeneProduct300054 (Entrez Gene)
FstGeneProduct24373 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
IfngGeneProduct25712 (Entrez Gene)
InhbaGeneProduct29200 (Entrez Gene)
Itgb6GeneProduct311061 (Entrez Gene)
Jak1GeneProduct84598 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
Lef1GeneProduct161452 (Entrez Gene)
LifGeneProduct60584 (Entrez Gene)
Ltbp1GeneProduct59107 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
NogGeneProduct25495 (Entrez Gene)
Runx2GeneProduct367218 (Entrez Gene)
Runx3GeneProduct156726 (Entrez Gene)
Serpine1GeneProduct24617 (Entrez Gene)
SkilGeneProduct114208 (Entrez Gene)
Smad1GeneProduct25671 (Entrez Gene)
Smad2GeneProduct29357 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
Smad4GeneProduct50554 (Entrez Gene)
Smad5GeneProduct59328 (Entrez Gene)
Smad6GeneProduct367100 (Entrez Gene)
Smad7GeneProduct81516 (Entrez Gene)
Smad9GeneProduct85435 (Entrez Gene)
Spp1GeneProduct25353 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
THBS1GeneProduct445442 (Entrez Gene) there are 5 types of tsp
Tcfe3GeneProduct317376 (Entrez Gene)
Tgfb1GeneProduct59086 (Entrez Gene)
Tgfbr1GeneProduct29591 (Entrez Gene)
Tgfbr2GeneProduct81810 (Entrez Gene)
Tgfbr3GeneProduct29610 (Entrez Gene)
Tgif1GeneProduct316742 (Entrez Gene)
TnfGeneProduct24835 (Entrez Gene)
Wnt1GeneProduct24881 (Entrez Gene)
Zeb2GeneProduct311071 (Entrez Gene)
Zfp423GeneProduct94188 (Entrez Gene)
Zfyve9GeneProduct313477 (Entrez Gene)

Annotated Interactions

No annotated interactions
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