SARS-CoV-2 innate immunity evasion and cell-specific immune response (Homo sapiens)

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CXCL4CXCL6CXCL3IFN-IIICXCL5CXCL10S1CXCL8CXCL11CXCL1CXCL13CXCL2CXCL7CXCL9CXCL1214, 234239, 239, 12, 23922, 232, 7169, 23237, 23169, 23999, 219, 209834, 92314, 234231, 19, 219, 1191691891623910, 239, 20dsRNACytokine stormRBDViral particleFunctional dysregulationNeutrophil recruitmentNETosisCytotoxic FunctionFunctional exhaustionRegulation of MHC II expression and cytokine productionProtein synthesisDMVAntiproliferative activityISGsMacrophageNucleusNeighbouring cellNeutrophilATII CellNK cellHDAC2CXCR2NSP13TRAF3ORF9bIgAMX1IFNB1CD16Interferon gamma-1bAP-1CCL2IFNAR1NSP12MAVSTFAP2ATRAF6ORF3bIgMIFN-INRAE1TLR7IRF723ORF3aCXCL8IL-6RIL-10LAG3ACE2IL-6STAT1KIRPTRIM25LGP2BSGTBK1NSP5IFNAR2NKG2ANSMAD3CXCL2NFKBCCL5Lung fibrosisTRADDIFITM1FADDNUP98ORF6P53TRAF2CCL3SMAD3TNFRIPK1CSF2TANKMNSP15STAT2IFIT2P300TGFB1LARP1IRF3ApoptosisTRAF5HAVCR2CCL4JAK1MDA5CASP8NMNFKBPIRF3PIRF7PAP-1PIL-6RViral particleACE2NSP10IL-6RORF3aORF9bDDX58NSP4CXCL17NNMX1IFITM1IFIT214, 2314, 239999, 23IFN-I2323RIPK18IFN-III


Description

SARS-CoV-2 Innate immunity evasion mechanisms and cell-specific immune responses; Metabolic overview over ATII cells infection

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Ontology Terms

 

Bibliography

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  1. Addetia, A., Lieberman, N. P., Phung, Q., Xie, H., Roychoudhury, P., Loprieno, M. A., et al.; ''SARS-CoV-2 ORF6 disrupts nucleocytoplasmic transport through interactions with Rae1 and Nup98''; bioRxiv, 2020 PubMed Europe PMC Scholia
  2. Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., et al.; ''Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China''; Lancet, 2020 PubMed Europe PMC Scholia
  3. Wang K, Chen W, Zhou Y-S, Lian J-Q, Zhang Z, Du P, et al.; ''SARS-CoV2 invades host cells via a el route: CD147-spike protein''; bioRxiv, 2020 PubMed Europe PMC Scholia
  4. Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., et al.; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing''; Nature, 2020 PubMed Europe PMC Scholia
  5. Yuen, C. K., Lam, J. Y., Wong, W. M., Mak, L. F., Wang, X., Chu, H., et al.; ''SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists.''; Emerg. Microbes Infect., 2020 PubMed Europe PMC Scholia
  6. Ahmad T, Chaudhuri R, Joshi MC, Almatroudi A, Rahmani AH, Ali SM; ''COVID-19: The Emerging Immunopathological Determinants for Recovery or Death.''; Front Microbiol, 2020 PubMed Europe PMC Scholia
  7. Blanco-Melo, D., Nilsson-Payant, B. E., Liu, W. C., Uhl, S., Hoagland, D., Møller, R., et al.; ''Imbalanced host response to SARS-CoV-2 drives development of COVID-19''; Cell, 2020 PubMed Europe PMC Scholia
  8. Zhang X, Wu K., Wang D., Yue X., Song D., Zhu Y., et al.; ''Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-κB.''; Virology, PubMed Europe PMC Scholia
  9. Taefehshokr N, Taefehshokr S, Hemmat N, Heit B; ''Covid-19: Perspectives on Innate Immune Evasion.''; Front Immunol, 2020 PubMed Europe PMC Scholia
  10. Wei, L., Ming, S., Zou, B., Wu, Y., Hong, Z., Li, Z., et al.; ''Viral invasion and Type I interferon response characterize the immunophenotypes during COVID-19 infection''; Epub ahead of print, 2020 PubMed Europe PMC Scholia
  11. Porta C, Hadj-Slimane R, Nejmeddine M, Pampin M, Tovey MG, Espert L, Alvarez S, Chelbi-Alix MK; ''Interferons alpha and gamma induce p53-dependent and p53-independent apoptosis, respectively.''; Oncogene, 2005 PubMed Europe PMC Scholia
  12. Stanley Perlman, Jason Netland; ''Coronaviruses post-SARS: update on replication and pathogenesis''; Nat Rev Microbiol., 2009 PubMed Europe PMC Scholia
  13. Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., et al.; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing''; Nature, 2020 PubMed Europe PMC Scholia
  14. Hadjadj, J., Yatim, N., Barnabei, L., Corneau, A., Boussier, J., Pere, H., et al; ''Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients.''; medRxiv, 2020 PubMed Europe PMC Scholia
  15. Ahmad T, Chaudhuri R, Joshi MC, Almatroudi A, Rahmani AH, Ali SM; ''COVID-19: The Emerging Immunopathological Determinants for Recovery or Death.''; Front Microbiol, 2020 PubMed Europe PMC Scholia
  16. Carsetti R, Zaffina S, Piano Mortari E, Terreri S, Corrente F, Capponi C, Palomba P, Mirabella M, Cascioli S, Palange P, Cuccaro I, Milito C, Zumla A, Maeurer M, Camisa V, Vinci MR, Santoro A, Cimini E, Marchioni L, Nicastri E, Palmieri F, Agrati C, Ippolito G, Porzio O, Concato C, Onetti Muda A, Raponi M, Quintarelli C, Quinti I, Locatelli F; ''Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases.''; Front Immunol, 2020 PubMed Europe PMC Scholia
  17. Ahmad T, Chaudhuri R, Joshi MC, Almatroudi A, Rahmani AH, Ali SM; ''COVID-19: The Emerging Immunopathological Determinants for Recovery or Death.''; Front Microbiol, 2020 PubMed Europe PMC Scholia
  18. Ren Y, Shu T, Wu D, Mu J, Wang C, Huang M, Han Y, Zhang XY, Zhou W, Qiu Y, Zhou X; ''The ORF3a protein of SARS-CoV-2 induces apoptosis in cells.''; Cell Mol Immunol, 2020 PubMed Europe PMC Scholia
  19. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ; ''A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.''; Nature, 2020 PubMed Europe PMC Scholia
  20. Zheng Y., Zhuang M-W., Han L., Zhang J., Nan M-L., Gao C., et al.; ''Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling''; bioRxiv, 2020 PubMed Europe PMC Scholia
  21. Chun-Kit Yuen, Joy-Yan Lam, Wan-Man Wong, Long-Fung Mak, Xiaohui Wang, Hin Chu, Jian-Piao Cai, Dong-Yan Jin, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Kin-Hang Kok; ''SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists''; Emerg Microbes Infect., 2020 PubMed Europe PMC Scholia
  22. Huang M, Jiang JD, Peng Z; ''Recent advances in the anti-HCV mechanisms of interferon.''; Acta Pharm Sin B, 2014 PubMed Europe PMC Scholia
  23. Ahmad T, Chaudhuri R, Joshi MC, Almatroudi A, Rahmani AH, Ali SM; ''COVID-19: The Emerging Immunopathological Determinants for Recovery or Death.''; Front Microbiol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
118888view12:12, 3 June 2021EweitzOntology Term : 'COVID-19' added !
118887view12:12, 3 June 2021EweitzOntology Term : 'immune response pathway' added !
116368view12:42, 4 May 2021EweitzModified title
115840view14:53, 18 March 2021Fehrhartfixed unconnected lines, added S1 ID
115234view07:45, 6 February 2021EgonwFixed the pink (#ffcccc) of the virus proteins
115233view07:43, 6 February 2021EgonwFixed an interaction type to binding.
115211view06:44, 5 February 2021MaintBotReplaced tow DOIs with the matching PubMed IDs
115174view17:46, 2 February 2021FehrhartCorrected some identifiers
115173view17:17, 2 February 2021FehrhartUntangled tangles, corrected some IDs
115153view09:43, 29 January 2021MaintBotReplaced another DOI with its corresponding PubMed identifier
115150view08:17, 29 January 2021EgonwFixed the format of PubMed identifiers.
115149view08:15, 29 January 2021EgonwReplaced DOIs with their matching Pubmed identifiers
114609view14:49, 25 January 2021Mkutmonremoved whitespaces in labels
114590view13:12, 24 January 2021AlinRusConnected nodes
114556view22:26, 20 January 2021NuraytalihReferences and Comments on immune response before viral cell entry
114554view16:13, 20 January 2021AlinRusAdded References;
114553view15:55, 20 January 2021AlinRusAddeed References
114552view14:14, 20 January 2021AlinRusAdded References;
114551view13:54, 20 January 2021AlinRusAdded References
114550view13:43, 20 January 2021AlinRusAdded References
114541view09:02, 20 January 2021AlinRusTNF added; Adjusted interactions
114538view21:28, 19 January 2021AlinRusCXCL17 added;
114537view20:21, 19 January 2021EgonwReplaced a PubMedCentral id with the matching Pubmed id
114523view13:44, 19 January 2021AlinRusChanged conversion-type interaction for +P; Added transcirption-translation interaction for ISGs
114522view13:38, 19 January 2021AlinRusAdded DDX38 for RIG-I; Changed database for N, NSP10, NSP13 proteins; Added NSP4
114516view06:17, 19 January 2021EgonwOntology Term : 'severe acute respiratory syndrome' added !
114515view06:17, 19 January 2021EgonwOntology Term : 'disease pathway' added !
114513view06:15, 19 January 2021EgonwModified title
114505view15:11, 18 January 2021AlinRusUpdate on M protein identifier
114504view15:06, 18 January 2021AlinRusNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACE2GeneProductENSG00000130234 (Ensembl)
AP-1ProteinB3KNW1 (Uniprot-TrEMBL)
ApoptosisPathwayWP254 (WikiPathways)
BSGProteinP35613 (Uniprot-TrEMBL) Basigin
CASP8ProteinQ14790 (Uniprot-TrEMBL) Caspase-8
CCL2GeneProductENSG00000108691 (Ensembl)
CCL3GeneProductENSG00000277632 (Ensembl)
CCL4GeneProductENSG00000275302 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CD16GeneProductENSG00000117281 (Ensembl)
CSF2ProteinP04141 (Uniprot-TrEMBL) GM-CSF
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL11GeneProductENSG00000169248 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL13GeneProductENSG00000156234 (Ensembl)
CXCL17GeneProductENSG00000189377 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL2GeneProduct2920 (Entrez Gene)
CXCL2GeneProductENSG00000081041 (Ensembl)
CXCL3GeneProductENSG00000163734 (Ensembl)
CXCL4GeneProductENSG00000163737 (Ensembl)
CXCL5GeneProductENSG00000163735 (Ensembl)
CXCL6GeneProduct6372 (Entrez Gene)
CXCL7GeneProductENSG00000163736 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CXCL9GeneProductENSG00000138755 (Ensembl)
CXCR2GeneProductENSG00000180871 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl) Binds to 5' PPP RNA region
FADDGeneProductENSG00000168040 (Ensembl)
HAVCR2GeneProduct84868 (Entrez Gene) TIM3
HDAC2GeneProductENSG00000196591 (Ensembl)
IFIT2GeneProduct3433 (Entrez Gene)
IFITM1Protein8519 (Entrez Gene)
IFN-IGeneProduct3438 (Entrez Gene)
IFN-IIIGeneProductPF15177 (Pfam)
IFN-IGeneProductPF00143 (Pfam)
IFNAR1ProteinENSG00000142166 (Ensembl)
IFNAR2ProteinENSG00000159110 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IL-10ProteinP22301 (Uniprot-TrEMBL)
IL-6ProteinB4DNV3 (Uniprot-TrEMBL)
IL-6RProteinA0N0L5 (Uniprot-TrEMBL)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
IgAComplexQ22327223 (Wikidata)
IgMComplexQ22327229 (Wikidata)
Interferon gamma-1bMetaboliteQ582356 (Wikidata)
JAK1ProteinENSG00000162434 (Ensembl)
KIRGeneProductENSG00000104970 (Ensembl)
LAG3GeneProduct3902 (Entrez Gene)
LARP1GeneProductENSG00000155506 (Ensembl)
LGP2GeneProductENSG00000108771 (Ensembl)
Lung fibrosisPathwayWP3624 (WikiPathways)
MAVSGeneProductENSG00000088888 (Ensembl)
MDA5Protein424185 (Entrez Gene)
MProteinP0DTC5 (Uniprot-TrEMBL)
MX1Protein4599 (Entrez Gene)
NFKBGeneProductENSG00000109320 (Ensembl)
NKG2AProteinAAL65234 (NCBI Protein)
NProteinP0DTC9 (Uniprot-TrEMBL)
NSP10ProteinYP_009742617 (Uniprot-TrEMBL)
NSP12ProteinQ94647436 (Wikidata)
NSP13Protein6ZSL (Uniprot-TrEMBL)
NSP15ProteinQ87917579 (Uniprot-TrEMBL)
NSP4ProteinYP_009742611 (NCBI Protein)
NSP5ProteinQ87917582 (Uniprot-TrEMBL)
NUP98GeneProductENSG00000110713 (Ensembl)
ORF3aProteinP0DTC3 (Uniprot-TrEMBL)
ORF3bProteinYP_009825053 (Uniprot-TrEMBL)
ORF6ProteinQ89226299 (Uniprot-TrEMBL)
ORF9bProteinP0DTD2 (Uniprot-TrEMBL)
P300GeneProductENSG00000100393 (Ensembl)
P53GeneProductENSG00000115129 (Ensembl)
RAE1GeneProductENSG00000101146 (Ensembl)
RIPK1GeneProductENSG00000137275 (Ensembl)
S1ProteinQ106020256 (Wikidata)
SMAD3GeneProductENSG00000166949 (Ensembl)
STAT1ProteinENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
TANKGeneProductENSG00000136560 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TNFProteinP01375 (Uniprot-TrEMBL)
TRADDGeneProductENSG00000102871 (Ensembl)
TRAF2GeneProductENSG00000127191 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF5GeneProductENSG00000082512 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRIM25GeneProductENSG00000121060 (Ensembl)

Annotated Interactions

No annotated interactions

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