ACE2 inhibition leads to pulmonary fibrosis (Homo sapiens)

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Bradykinin system, hyperactivatedKE1740: ACE2 inhibitionIncreased, secretion of proinflammatory and profibrotic mediatorsRenin Angiotensin Aldosterone SystemMetabolism of Angiotensinogen to AngiotensinsBradykinin receptor B1 activationNF-KB pathwayBradykinin signaling networkIncreased, Reactive oxygen speciesOxidative stressIncrease activation, Nuclear factor kappa B (NF-kB)Prostaglandin signalingKE1752: Increased Angiotensin IIKE1743: Increased plasma Angiotensin IIKE68: Collagen AccumulationKE1276: Lung FibrosisCollagen biosynthesis and modifying enzymesBinding of agonist, Angiotensin II receptor type 1 receptor (AT1R)Angiotensin II receptor type 1 pathwayACE2 inhibitionIncreased, Prostaglandin E2 secretionKinin-Kallikrein PathwayOverview of proinflammatory and profibrotic mediators


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118508view09:17, 28 May 2021FinterlyReplace DataNode Type "Key Event" with "Event"
116869view20:52, 14 May 2021Marvin M2Added KE pathway and connected line
116321view11:36, 30 April 2021Marvin M2added KE pathways
116261view12:51, 22 April 2021Marvin M2added chain of bradykinin and prostaglandin
116260view11:17, 22 April 2021Marvin M2corrected WP IDs
116232view14:38, 21 April 2021Marvin M2Ontology Term : 'fibroblast' added !
116231view14:38, 21 April 2021Marvin M2Ontology Term : 'angiotensin II signaling pathway via AT1 receptor' added !
116230view14:36, 21 April 2021Marvin M2Ontology Term : 'pulmonary fibrosis' added !
116229view14:36, 21 April 2021Marvin M2Ontology Term : 'COVID-19' added !
116227view13:16, 21 April 2021Marvin M2
116226view13:15, 21 April 2021Marvin M2typo in database
116225view13:15, 21 April 2021Marvin M2
116224view13:10, 21 April 2021Marvin M2Added KEs for AOP382
114326view08:52, 7 January 2021Marvin M2
114325view08:51, 7 January 2021Marvin M2
114321view17:37, 6 January 2021Marvin M2New pathway

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NameTypeDatabase referenceComment
ACE2 inhibitionPathwayWP554 (WikiPathways)
Angiotensin II receptor type 1 pathwayPathwayWP5036 (WikiPathways)
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)Event1851 (AOP-Wiki KE)
Bradykinin receptor B1 activation
Bradykinin signaling networkPathwayWP5068 (WikiPathways)
Bradykinin system, hyperactivated1867 (AOP-Wiki KE)
Collagen biosynthesis and modifying enzymesPathwayWP2725 (WikiPathways)
Increase activation, Nuclear factor kappa B (NF-kB)Event1172 (AOP-Wiki KE)
Increased, Prostaglandin E2 secretion1 (AOP-Wiki KE)
Increased, Reactive oxygen speciesEvent1115 (AOP-Wiki KE)
Increased, secretion of proinflammatory and profibrotic mediators1496 (AOP-Wiki KE)
KE1276: Lung FibrosisEvent1276 (AOP-Wiki KE)
KE1740: ACE2 inhibitionEvent1740 (AOP-Wiki KE)
KE1743: Increased plasma Angiotensin IIEvent1743 (AOP-Wiki KE)
KE1752: Increased Angiotensin IIEvent1752 (AOP-Wiki KE)
KE68: Collagen AccumulationEvent68 (AOP-Wiki KE)
Kinin-Kallikrein PathwayPathwayWP5089 (WikiPathways)
Metabolism of Angiotensinogen to AngiotensinsPathwayWP2729 (WikiPathways)
NF-KB pathwayPathwayWP4562 (WikiPathways)
Overview of proinflammatory and profibrotic mediatorsPathwayWP5095 (WikiPathways)
Oxidative stressPathwayWP408 (WikiPathways)
Prostaglandin signalingPathwayWP5088 (WikiPathways)
Renin Angiotensin Aldosterone SystemPathwayWP4756 (WikiPathways)

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