nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell (Homo sapiens)

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Eukaryotic translation initiationfactor 3 complexEIF3BEIF3HEIF3IEIF3GEIF3DEIF3JEIF3EEIF3CEIF3AEIF3F40S cytosolic small ribosomal subunit1Load mRNA and start translation40S cytosolic small ribosomal subunitTernary complexnsp143S Pre-initiation ComplexEukaryotic translation initiationfactor 3 complexmet-tRNAiEIF3BEIF3HEIF2S2EIF2S3EIF3IEIF5EIF3GEIF3DEIF2S1EIF3JEIF3EEIF3CEIF3AEIF3FEIF1AEIF1EIF5EIF1AEIF1Eukaryotic translation initiationfactor 3 complexEIF3BEIF3HEIF3IEIF3GEIF3DEIF3JEIF3EEIF3CEIF3AEIF3F40S cytosolic small ribosomal subunitEIF5EIF1AEIF1Ternary complexmet-tRNAiEIF2S2EIF2S3EIF2S1


The pathway depicted how nsp1 from SARS-CoV 2 may inhibit translation in the host cell (Yuan S et al 2020, PubMed 33188728). nsp1 protein competes with the EIF3J subunit of the EIF3s complex for binding to the 40S ribosomal subunit. The resulted 43S pre-initiation complex can no longer load the mRNA from the host cell for starting translation.

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Ontology Terms



  1. Yuan S, Peng L, Park JJ, Hu Y, Devarkar SC, Dong MB, Shen Q, Wu S, Chen S, Lomakin IB, Xiong Y; ''Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.''; Mol Cell, 2020 PubMed Europe PMC Scholia


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120060view18:55, 25 October 2021Mkutmonupdate layout
118884view12:10, 3 June 2021EweitzOntology Term : 'PW:0000101' removed !
118883view12:10, 3 June 2021EweitzOntology Term : 'translation initiation pathway' added !
118881view12:08, 3 June 2021EweitzOntology Term : 'COVID-19' added !
114436view13:06, 11 January 2021FehrhartOntology Term : 'viral infectious disease' added !
114435view13:05, 11 January 2021FehrhartOntology Term : 'severe acute respiratory syndrome' added !
114078view06:39, 21 December 2020EgonwModified title
114064view21:57, 18 December 2020Mkutmonremove nested group
114063view21:33, 18 December 2020Mkutmonfix xml error
114058view14:29, 18 December 2020NhungPNew pathway

External references


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NameTypeDatabase referenceComment
40S cytosolic small ribosomal subunitComplexCPX-5223 (Complex Portal)
43S Pre-initiation Complex
EIF1GeneProduct10209 (Entrez Gene)
EIF1AGeneProduct1964 (Entrez Gene) Also known as EIF1AX
EIF2S1GeneProduct1965 (Entrez Gene)
EIF2S2GeneProduct8894 (Entrez Gene)
EIF2S3GeneProduct1968 (Entrez Gene)
EIF3AGeneProduct8661 (Entrez Gene)
EIF3BGeneProduct8662 (Entrez Gene)
EIF3CGeneProduct8663 (Entrez Gene)
EIF3DGeneProduct8664 (Entrez Gene)
EIF3EGeneProduct3646 (Entrez Gene)
EIF3FGeneProduct8665 (Entrez Gene)
EIF3GGeneProduct8666 (Entrez Gene)
EIF3HGeneProduct8667 (Entrez Gene)
EIF3IGeneProduct8668 (Entrez Gene)
EIF3JGeneProduct8669 (Entrez Gene)
EIF5GeneProduct1983 (Entrez Gene)
Eukaryotic translation initiation

factor 3 complex

ComplexCPX-6036 (Complex Portal)
Ternary complexComplex
met-tRNAiMetaboliteCHEBI:13145 (ChEBI)
nsp1ProteinQ90038952 (Wikidata) wikidata Q90038952

Annotated Interactions

No annotated interactions

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