Hypoxia-dependent proliferation of myoblasts (Mus musculus)

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652102811183134739417351Elf4EIGF1PI3KR1PI3KVEGFTSC2HGFproliferation andlate differentiationMTOR1CalcitriolMYF5AKTMYOD1Smad3MSTNSmad2MYOGRHEBAMPKTrim63Fbxo32FGFDDIT44TSC1


Molecular mechanisms involved in myogenic proliferation during hypoxia. Black arrow: activation of the signaling pathway/ protein/ molecule. Blunt red arrow: inhibition of the signaling pathway/protein/ molecule.

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  1. Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, Simon MC; ''O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling.''; Mol Cell Biol, 2012 PubMed Europe PMC Scholia
  2. Fonville M, Friesema IH, Hengeveld PD, Docters van Leeuwen A, Jahfari S, Harms MG, van Vliet AJ, Hofhuis A, van Pelt W, Sprong H, van den Wijngaard CC; ''Human exposure to tickborne relapsing fever spirochete Borrelia miyamotoi, the Netherlands.''; Emerg Infect Dis, 2014 PubMed Europe PMC Scholia
  3. Hauerslev S, Vissing J, Krag TO; ''Muscle atrophy reversed by growth factor activation of satellite cells in a mouse muscle atrophy model.''; PLoS One, 2014 PubMed Europe PMC Scholia
  4. Chargé SB, Rudnicki MA; ''Cellular and molecular regulation of muscle regeneration.''; Physiol Rev, 2004 PubMed Europe PMC Scholia
  5. Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ; ''The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  6. KRUPER DC, PATTON RA, KOSKOFF YD; ''Delayed object-quality discriminations in hemicerebrectomized monkeys.''; J Comp Physiol Psychol, 1961 PubMed Europe PMC Scholia
  7. Zhang GW, Gu TX, Sun XJ, Wang C, Qi X, Wang XB, Li-Ling J; ''Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model.''; J Thorac Cardiovasc Surg, 2016 PubMed Europe PMC Scholia
  8. Lee SJ, McPherron AC; ''Regulation of myostatin activity and muscle growth.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
  9. Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN; ''1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells.''; Endocrinology, 2011 PubMed Europe PMC Scholia
  10. Wang C, Liu W, Liu Z, Chen L, Liu X, Kuang S; ''Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein.''; J Biol Chem, 2015 PubMed Europe PMC Scholia


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119059view23:52, 13 June 2021KhanspersOntology Term : 'phosphatidylinositol 3-kinase-Akt signaling pathway' added !
119058view23:52, 13 June 2021KhanspersOntology Term : 'signaling pathway' added !
118850view09:52, 2 June 2021ExperiMedmoved PMID of the interactions to full references
117899view10:25, 23 May 2021EweitzOntology Term : 'myoblast' added !
117898view10:25, 23 May 2021EweitzModified title
116341view12:39, 2 May 2021L DupuisConnected line
114007view14:49, 17 December 2020LaurentConnected line
114006view14:49, 17 December 2020LaurentConnected lines
113996view12:56, 16 December 2020ExperiMedNew pathway

External references


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NameTypeDatabase referenceComment
AKTGeneProduct11651 (Entrez Gene)
CalcitriolProteinP70160 (Uniprot-TrEMBL)
DDIT44GeneProduct74747 (Entrez Gene)
FGFGeneProduct14164 (Entrez Gene)
Fbxo32GeneProduct67731 (Entrez Gene)
HGFGeneProduct15234 (Entrez Gene)
IGF1GeneProduct16000 (Entrez Gene)
MSTNGeneProduct17700 (Entrez Gene)
MTOR1GeneProduct56717 (Entrez Gene)
MYF5GeneProduct17877 (Entrez Gene)
MYOD1GeneProduct17927 (Entrez Gene)
MYOGGeneProduct17928 (Entrez Gene)
RHEBGeneProduct19744 (Entrez Gene)
Smad2GeneProduct17126 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
TSC1GeneProduct64930 (Entrez Gene)
TSC2GeneProduct22084 (Entrez Gene)
Trim63GeneProduct433766 (Entrez Gene)
VEGFGeneProduct22339 (Entrez Gene)
proliferation and late differentiation

Annotated Interactions

No annotated interactions

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