Hypoxia-dependent self-renewal of myoblasts (Mus musculus)

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3, 43, 45, 621082771093, 43, 41910211Hey1Hes1Hey2PAX7MYHMYF5Self renewalCDKN1AHypoxiaMYOGRBMyotube formationMYOD1miR206Notch-pathwayMAPK14FoxO1HIF1aWNT non canonicalmiR1HSP90


Molecular mechanisms involved in self-renewal of satellite cells in hypoxia. Black arrows: activation of the signaling pathway / protein / molecule. Blunt red arrow: inhibition of the signaling pathway / protein / molecule. Round blue arrow: interaction between two pathways.

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  1. Ren H, Accili D, Duan C; ''Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC Scholia
  2. Liu W, Wen Y, Bi P, Lai X, Liu XS, Liu X, Kuang S; ''Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation.''; Development, 2012 PubMed Europe PMC Scholia
  3. Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, Simon MC; ''O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling.''; Mol Cell Biol, 2012 PubMed Europe PMC Scholia
  4. Sinha KM, Tseng C, Guo P, Lu A, Pan H, Gao X, Andrews R, Eltzschig H, Huard J; ''Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.''; FASEB J, 2019 PubMed Europe PMC Scholia
  5. Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ; ''microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7.''; J Cell Biol, 2010 PubMed Europe PMC Scholia
  6. Dey BK, Gagan J, Dutta A; ''miR-206 and -486 induce myoblast differentiation by downregulating Pax7.''; Mol Cell Biol, 2011 PubMed Europe PMC Scholia
  7. Horak M, Novak J, Bienertova-Vasku J; ''Muscle-specific microRNAs in skeletal muscle development.''; Dev Biol, 2016 PubMed Europe PMC Scholia
  8. Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D; ''A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.''; J Clin Invest, 2007 PubMed Europe PMC Scholia
  9. Li X, Zhu L, Chen X, Fan M; ''Effects of hypoxia on proliferation and differentiation of myoblasts.''; Med Hypotheses, 2007 PubMed Europe PMC Scholia
  10. Di Carlo A, De Mori R, Martelli F, Pompilio G, Capogrossi MC, Germani A; ''Hypoxia inhibits myogenic differentiation through accelerated MyoD degradation.''; J Biol Chem, 2004 PubMed Europe PMC Scholia


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119055view23:48, 13 June 2021KhanspersOntology Term : 'Wnt signaling pathway' added !
119054view23:48, 13 June 2021KhanspersOntology Term : 'Notch signaling pathway' added !
119053view23:44, 13 June 2021KhanspersOntology Term : 'myoblast' added !
118853view10:05, 2 June 2021ExperiMedcorrected one reference
118852view10:03, 2 June 2021ExperiMedmoved PMID of the interactions to full references
117900view10:27, 23 May 2021EweitzModified title
114233view21:58, 27 December 2020Andrareference
114232view21:54, 27 December 2020Andraconnecting lines
113995view12:53, 16 December 2020ExperiMedNew pathway

External references


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NameTypeDatabase referenceComment
CDKN1AGeneProduct12575 (Entrez Gene)
FoxO1GeneProduct56458 (Entrez Gene)
HIF1aGeneProduct15251 (Entrez Gene)
HSP90GeneProductENSMUSG00000020048 (Ensembl)
Hes1GeneProduct15205 (Entrez Gene)
Hey1GeneProduct15213 (Entrez Gene)
Hey2GeneProduct15214 (Entrez Gene)
MAPK14GeneProductMAPK14 (HGNC)
MYF5GeneProduct17877 (Entrez Gene)
MYHGeneProduct17879 (Entrez Gene)
MYOD1GeneProduct17927 (Entrez Gene)
MYOGGeneProduct17928 (Entrez Gene)
Myotube formation
Notch-pathwayPathway18128 (Entrez Gene)
PAX7GeneProduct18509 (Entrez Gene)
Self renewal
WNT non canonicalPathway
miR1 Rna

Annotated Interactions

No annotated interactions

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