SARS-CoV-2 Infection (Homo sapiens)

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24, 6716212, 36, 43, 74, 125...3511, 120, 127, 1397914320138102112499810019, 108, 109, 1368892441, 64, 104, 1272416322, 518015712, 24, 159112, 138849898, 1653529, 1431438015, 18, 23, 30, 398919, 109, 12814756, 114, 140, 150, 151, 1536, 25, 10040, 48, 97, 1441005, 19, 108, 109, 12815811045, 114205, 8, 12, 13, 22...1071269014827, 28, 57, 92, 134...32, 16631, 49, 96, 115, 129146, 9926, 941221238065, 88, 161212, 15, 30, 43, 73...802059, 82, 83, 85, 86, 113...353, 5, 12, 36, 55...32, 60, 16616268, 12752, 77, 118, 13269, 95, 119, 14516351445, 114, 13559, 82, 83, 85, 86, 113...10, 1763, 1542626266962, 789011714998126101891621116, 100, 15480, 91989059, 82, 83, 85, 86, 113...3515, 18, 20, 23, 33...98nucleolusGolgi membraneexocytic vesicleGolgi lumendouble membrane vesicle viral factory outer membraneendocytic vesicle lumenManually changed size and positionof complexes for readability:cytosolendoplasmic reticulum-Golgi intermediate compartment membraneautophagosomeendoplasmic reticulum membranemRNA6 Ub-3xPalmC-E pp1a-nsp11pp1a-nsp6 mRNA4 pp1a-nsp6 fully glycosylated Spike pp1ab-nsp13 pp1a-nsp7 H2OGALNT1pp1ab-nsp14 pp1ab-nsp6 pp1ab-nsp7 m7G(5')pppAm-capped,polyadenylated-mRNA9 pp1ab-nsp7 phospho-SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp2 Ub-3xPalmC-E PARPspp1ab-nsp6 PPimRNA9 pp1ab-nsp16 GSK3Bnsp7:nsp8:nsp12:nsp14:nsp10:nsp13:nsp15pp1ab-nsp10 pp1a-nsp6 PPipp1a-nsp10 phospho-SUMO1-K62-ADPr-p-S177-Ncap a nucleotide sugarpp1ab-nsp10 GSK3A N-glycan pp1ab-nsp3-4 pp1a-nsp8 mRNA2 minus strand m7G(5')pppAm-capped,polyadenylated mRNA5pp1ab-nsp8 pp1a-nsp8 RNA primer pp1ab-nsp15 pp1ab-nsp12 pp1ab-nsp15 7a nsp1UBC(153-228) S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramerN-glycan nsp3pp1ab-nsp1-4complex N-glycan-PALM-Spike S1 Fragment PARP14 7a camostat pp1ab-nsp4 m7G(5')pppAm-mRNA2 CHMP3 RPN1 m7G(5')pppAm-mRNA7 pp1ab-nsp9 DAD1 S3:M:E:encapsidatedSARS-CoV-2genomicRNA:7a:O-glycosyl3atetramer:glycosylated-ACE2nsp7:nsp8:nsp12:nsp14:nsp10:nsp13pp1ab-nsp16 M O-glycosyl 3atetramerPARP9 pp1ab-nsp14 S1:S2:M:E:7a:O-glycosyl 3atetramerm7GpppA-cappedSARS-CoV-2 genomicRNA (plus strand)m7G(5')pppAm-capped,polyadenylatedSARS-CoV-2 genomicRNA (plus strand)fully glycosylated Spike 9bnsp10:nsp14m7G(5')pppAm-capped,polyadenylated-mRNA9pp1a-nsp3 SARS-CoV-2gRNA:RTC:RNA primerUb-3xPalmC-E FURINCHMP4C ZCRB1 S3:M:E:encapsidated SARS-CoV-2 genomicRNA:7a:O-glycosyl3a tetramerdi-antennary N-glycan-PALM-Spike pp1a-nsp6 pp1a-nsp6 nsp7:nsp8:nsp12SARS-CoV-2 gRNAcomplement (minusstrand):RTCpp1ab-nsp16 phospho-SUMO1-K62-ADPr-p-S177-Ncap Ubpp1ab-nsp9 STT3A nsp4pp1app1a-nsp4 nucleoside5'-diphosphate(3-)NTPpp1a-nsp10 pp1ab-nsp16 pp1a-nsp10 pp1ab-nsp15m7G(5')pppAm-capped,polyadenylated mRNA4 complex N-glycan-PALM-Spike S1 Fragment m7GpppA-mRNA7 pp1ab-nsp16 CQ, HCQpp1a-nsp8 pp1a-nsp6 high-mannose N-glycan-PALM-Spike pp1a-nsp8 PARP6 Ub-3xPalmC-EpentamerN-glycan nsp4pp1ab-nsp3 phospho-ADPr-p-S177-Ncappp1ab-nsp14 M VHL UBB(1-76) N-glycan pp1a-nsp3 pp1ab-nsp7 GalNAc-O-3aNHC pp1ab-nsp8 pp1ab-nsp161-deoxynojirimycin CHMP4B mRNA7a minus strand SARS-CoV-2 minusstrand subgenomicmRNAsH2OSARS-CoV-2 gRNAcomplement (minusstrand):RTC:RTCinhibitorsNcap tetramerpp1a-nsp10 pp1ab-nsp8 UVRAG complexCTSL:CTSL inhibitorspp1a-nsp8 UVRAG pp1ab-nsp13pp1ab-nsp13 H+Ncap tetramerN-glycan M CQ2+, HCQ2+H+PRKCSH m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) RB1pp1ab-nsp7O-glycosyl 3app1ab-nsp8 pp1ab-nsp16 UBE2I-G97-SUMO1 pp1ab-nsp7 UBB(153-228) SUMO1-C93-UBE2I pp1a-nsp10 pp1ab-nsp14 CMPO-glycosyl 3a MOGS pp1a-nsp3 Pim7G(5')pppAm-capped,polyadenylated mRNA5 NTPUBC(533-608) nascent Epp1a-nsp8 glycosylated-ACE2NTPMlattice:Eprotein:encapsidated SARS-CoV-2 genomic RNApp1a-nsp4 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) fully glycosylated Spike 3aS3:M:E:encapsidatedSARS-CoV-2 genomicRNA: 7a:O-glycosyl3a tetramerpp1ab-nsp15 pp1ab-nsp8ST6GALNAC4 PPiphospho-SUMO1-K62-ADPr-p-S177-Ncap pp1a-nsp7 MOGSO-glycosyl 3atetramerN-glycan nsp3-4DOLPpp1ab-nsp6 CTSL inhibitorsmRNA9 minus strand GTPphospho-SUMO1-K62-ADPr-p-S177-Ncap m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) pp1a-nsp7 H2OPiUb-3xPalmC-E nsp9nsp16:VHLVHLRB1 O-glycosyl 3a pp1a-nsp3 M MAP1LC3Bnsp1-4pp1ab-nsp14m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) pp1ab-nsp3 pp1a-nsp8 encapsidatedSARS-CoV-2 genomicRNApp1ab-nsp7 3CLp dimerpp1ab-nsp6 nsp7:nsp8:nsp12:nsp14:nsp10nsp8pp1ab-nsp15 7a UBA52(1-76) RPN2 N-glycan pp1ab-nsp3 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) beta-D-glucosepp1a-nsp8 pp1a-nsp10Host Derived Lipid Bilayer Membrane pp1a-nsp10 pp1ab-nsp7 3am7GpppA-mRNA9 pp1a-nsp6 pp1ab-nsp6 pp1ab-nsp15 pp1ab-nsp8 pp1ab-nsp15 nucleotide-sugarpp1ab-nsp8 pp1a-nsp4 m7G(5')pppAm-mRNA3 ST3GAL3 nsp16:nsp10SARS-CoV-2 nascent genomic RNA complement (minus strand) with mismatched 3' nucleotide pp1ab-nsp10 (Glc)3 (GlcNAc)2(Man)9 (PP-Dol)1pp1ab-nsp10 nsp6ST6GAL1 S3:M:E:encapsidatedSARS-CoV-2 genomicRNA: 7a:O-glycosyl3a tetramernascent MN-glycan M pp1a-nsp6 N-glycan nsp3pp1ab-nsp8 phospho-SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp7 UBC(77-152) EDEM2 pp1ab-nsp16 ER-alpha-glucosidaseinhibitorspp1ab-nsp8 N-glycan pp1a-nsp4 TMPRSS2:TMPRSS2inhibitorspp1ab-nsp12 m7G(5')pppAm-capped,polyadenylated mRNA6 pp1a-nsp7 nucleoside5'-diphosphate(3−)m7GpppA-mRNA3 pp1ab-nsp12 a nucleotide sugarCHMP2B pp1ab-nsp13 N-glycan MBECN1 M PPiO-glycosyl 3a pp1ab-nsp6 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) pp1a-nsp6 di-antennaryN-glycan-PALM-SpiketrimerNcap tetramerO-glycosyl 3aPipp1ab-nsp4 SARS-CoV-2 gRNA:RTCSARS-CoV-2 genomicRNA (plus strand)pp1ab-nsp15 O-glycosyl 3a nucleoside5'-diphosphate(3-)pp1ab-nsp3 ESCRT-IIImRNA5 minus strand S3:M:E:encapsidated SARS-CoV-2 genomicRNA:O-glycosyl 3atetramernsp15 hexamertri-antennaryN-glycan-PALM-Spiketrimerpp1ab-nsp14 mRNA4 minus strand 7a m7G(5')pppAm-capped SARS-CoV-2 genomic RNA complement (minus strand) RPS27A(1-76) 3xPalmC-EUb-3xPalmC-E pp1ab-nsp13 SARS coronavirusgRNA with secondarystructure:RTCST6GALNAC2 pp1a-nsp4 pp1ab-nsp10 PARP8 pp1ab-nsp6 pp1ab-nsp13 pp1ab-nsp8 O-glycosyl 3a m7G(5')pppAm-cappedSARS-CoV-2 genomicRNA complement(minus strand)m7G(5')pppAm-capped,polyadenylated mRNA7 m7G(5')pppAm-capped,polyadenylated mRNA2 fully glycosylated Spike Ub-3xPalmC-E CTSL(292-333) m7GpppA-mRNA5 NMPpp1a-nsp8 pp1a-nsp3 pp1a-nsp3 pp1ab-nsp6 pp1ab-nsp10 RTCpp1ab-nsp4 DDX5pp1a-nsp10 mRNA5 pp1a-nsp3 pp1a-nsp7 high-mannoseN-glycan-PALM-Spikepp1ab-nsp10 TMPRSS2 pp1a-nsp7 nsp10fully glycosylatedSpike trimerNHC pp1a-nsp7MGAT2pp1ab-nsp7 fully glycosylated Spike pp1ab-nsp4 pp1a-nsp1-4nsp2pp1ab-nsp10 complex N-glycan-PALM-Spike S2 Fragment pp1a-nsp3 pp1a-nsp6O-glycosyl 3a GSK3B pp1ab-nsp12M latticepp1ab-nsp3 pp1ab-nsp12 pp1a-nsp8 pp1a-nsp4 M phospho-SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp12 H2Opp1a-nsp9 pp1ab-nsp6 PPiNcap tetramerMAP1LC3B m7G(5')pppAm-mRNA6 N-glycanpp1ab-nsp3-4nsp77a GSK3pp1ab-nsp7 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) pp1a-nsp7 Ub-3xPalmC-Epp1ab-nsp8 pp1ab-nsp13 pp1a-nsp4 7a nucleoside5'-diphosphate(3−)pp1ab-nsp3 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) H+SARS-CoV-2 genomicRNA complement(minus strand)mRNA2 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) mRNA8 pp1a-3CL pp1a-nsp4 m7GpppA-SARS-CoV-2plus strandsubgenomic mRNAsO-glycosyl 3a α-KetoamidesST3GAL2 pp1ab-nsp7 Ub-3xPalmC-E pp1ab-nsp15 m7GpppA-mRNA6 pp1ab-nsp8 pp1a-nsp3 pp1ab-nsp3 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) pp1a-nsp8 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) Mpp1a-nsp3 pp1a-nsp7 fully glycosylated Spike S-adenosyl-L-methioninepp1a-nsp7 RTC inhibitorspp1ab-nsp6nsp5pp1ab-nsp10 pp1a-nsp10 nsp7:nsp8fully glycosylatedSpike trimerM pp1ab-nsp4 pp1ab-nsp14 SARS-CoV-2gRNA:RTC:nascentRNA minus strandm7G(5')pppAm-capped,polyadenylated mRNA3 Ub-3xPalmC-E pp1ab-nsp12 ATPmRNA3 complex N-glycan-PALM-Spike S1 Fragment pp1ab-nsp16 m7GpppA-mRNA8 MAN2A1m7GpppA-mRNA4 pp1ab-nsp16 PPim7G(5')pppAm-capped,polyadenylated mRNA4phospho-SUMO1-K62-ADPr-p-S177-Ncap CHMP7 m7G(5')pppAm-capped,polyadenylatedSARS-CoV-2subgenomic mRNAs(plus strand)pp1a-nsp9pp1ab-nsp8 pp1ab-nsp13 pp1a-nsp10 CHMP2A ATPnsp13:DDX5S3:M:E:encapsidatedSARS-CoV-2genomicRNA:7a:O-glycosyl3atetramer:glycosylated-ACE2SARS-CoV-2gRNA:RTC:nascentRNA minusstrand:RTCinhibitorspp1ab-nsp16 phospho-SUMO1-K62-ADPr-p-S177-Ncap RTC inhibitorspp1ab-nsp16 UBE2IN-glycan pp1a-nsp3-4 pp1a-nsp3 pp1ab-nsp4 pp1ab-nsp12 pp1a-nsp1-4 glycosylated-ACE2 pp1ab-nsp3 MAP1LC3BN-glycan pp1a-nsp3 UBB(77-152) pp1ab-nsp3-4 M ADPpp1ab-nsp10 pp1ab-nsp14 H+N-glycan M pp1a-nsp6 m7G(5')pppAm-cappedSARS-CoV-2 genomicRNA (plus strand)pp1ab-nsp14 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) pp1a-nsp10 ER-alphaglucosidases:ER-alpha glucosidase inhibitorspp1ab-nsp4 pp1ab-nsp14 FUT8pp1ab-nsp7 pp1a-nsp6 NTPpp1a-nsp10 high-mannose N-glycan-PALM-Spike N-glycan pp1ab-nsp3 pp1ab-nsp8 pp1ab-nsp8 MGAT1nsp3PARP10 pp1ab-nsp8 fully glycosylated Spike pp1a-nsp3 pp1a-nsp8 pp1a-nsp7 TMPRSS2nsp3-4S-adenosyl-L-methioninePiUBC(305-380) CHMP6 MGAT4smRNA8 minus strand H+pp1ab-nsp13 mRNA7a pp1a-nsp10 SARS-CoV-2 plusstrand subgenomicmRNAsO-glycosyl 3a pp1a-nsp8 GSK3B:GSKipp1ab-nsp15 CANXcomplex N-glycan-PALM-Spike S2 Fragment fully glycosylated Spike CTSL(292-333) O-glycosyl 3atetramerphospho-SUMO1-K62-ADPr-p-S177-Ncap mRNA7b minus strand nsp3:nsp4pp1a-nsp7 S-adenosyl-L-homocysteineTMPRSS2S1:S2:M lattice:EproteinMan(9) N-glycanunfolded Spikehigh-mannoseN-glycan unfoldedSpikenucleotide-sugarm7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) H2Opp1ab-nsp3 H2Ophospho-p-S177-Ncappp1ab-nsp3 MGAT4B pp1ab-nsp7 pp1ab-nsp12 phospho-SUMO1-K62-ADPr-p-S177-Ncap glycosylated-ACE2nascent SpikeZCRB114-sugar N-glycanunfolded Spikepp1a-nsp3 PIK3R4 pp1ab-nsp16 UBC(609-684) SARS-CoV-2 nascent genomic RNA complement (minus strand) m7G(5')pppAm-mRNA9 GANAB pp1ab-nsp4 SARS-CoV-2 nascent genomic RNA complement (minus strand) pp1a-nsp10 m7G(5')pppAm-mRNA4 pp1ab-nsp1-4 NcapO-glycosyl 3a S-adenosyl-L-homocysteinepp1a-nsp4 NHC pp1ab-nsp12 CTSL(114-288) M mRNA3 minus strand M ERalpha-glucosidasespp1a-nsp2 ACE2MGAT4C pp1ab-nsp13 pp1a-nsp8 nsp9 dimerNAD+pp1ab-nsp14 NcapM m7G(5')pppAm-capped,polyadenylated mRNA8 ST6GALNAC3 m7GpppA-mRNA2 pp1a-nsp7 nsp15:RB1nsp8pp1a-nsp4 Ub-3xPalmC-E pp1ab-nsp10O-glycosyl 3a 7a pp1ab-nsp15 pp1ab-nsp4 ATPO-glycosyl 3a phospho-SUMO1-K62-ADPr-p-S177-Ncap S3:M:E:encapsidatedSARS-CoV-2 genomicRNA: 7a:O-glycosyl3a tetramerGSKiphospho-SUMO1-K62-ADPr-p-S177-Ncap pp1a-nsp4 high-mannoseN-glycan foldedSpikepp1ab-nsp7 H2Om7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) pp1a-nsp6 Ub-3xPalmC-E Cathepsin L1pp1a-nsp7 pp1a dimerpp1a-nsp7 RNA primer H2Opp1ab-nsp6 DDOST UBC(381-456) CQ, HCQpp1ab-nsp14 phospho-SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp7 pp1a UBC(457-532) CHMP4A CoA-SHphospho-SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp6 ADPpp1a-nsp8 SUMO-p-Ncapdimer:SARS-CoV-2genomic RNApp1ab-nsp5 TMPRSS2 inhibitorspp1a-nsp10 S-adenosyl-L-methioninepp1ab-nsp13 Ub-3xPalmC-E m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) m7G(5')pppAm-capped,polyadenylated mRNA2N-glycan M pp1a-nsp4 O-glycosyl 3a nsp6nsp3:nsp4:nsp6pp1ab-nsp8 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) Ncap tetramerpp1a-nsp1 phospho-SUMO1-K62-ADPr-p-S177-Ncap S-adenosyl-L-homocysteinepp1a-nsp8 Npp1a-nsp9 pp1ab-nsp14 pp1a-nsp7 tri-antennary N-glycan-PALM-Spike N-glycan M Ub-3xPalmC-EpentamerADPN-glycan M phospho-p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-Npp1ab-nsp10 MAN1B1 GTPN-glycan M pp1ab-nsp10 ST3GAL1 pp1ab-nsp12 pp1ab-nsp13 fully glycosylated Spike high-mannoseN-glycan-PALM-Spiketrimersialyltransferasesteicoplanin pp1ab-nsp8 pp1ab-nsp4 UBC(229-304) MAGT1 pp1ab-nsp3 ATP7app1a-nsp10 PPiphospho-SUMO1-K62-ADPr-p-S177-NcapNAMpp1a-3CL pp1ab-nsp1 high-mannoseN-glycan-PALM-Spiketrimerpp1ab-nsp4 N-glycan M pp1a-nsp6-11GTPpp1a-nsp3-4 UDPN-glycan MMGAT4A(1-535) m7G(5')pppAm-capped,polyadenylated mRNA3Ncap tetramerpp1ab-nsp5 3CLpdimer:α-KetoamidesUBC(1-76) 3a:membranousstructurepp1ab-nsp15 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) UDP-GalNAcpp1ab-nsp5pp1ab-nsp10 SARS coronavirusgRNA:RTC:nascentRNA minus strandwith mismatchednucleotidepp1ab-nsp10 m7GpppA-cappedSARS-CoV-2 genomicRNA complement(minus strand)pp1ab-nsp7 pp1ab-nsp3 palmitoyl-CoApp1a-nsp10 PPim7G(5')pppAm-SARS-CoV-2 plus strand subgenomic mRNAsPRKCSH complex N-glycan-PALM-Spike S2 Fragment pp1a-nsp7 CMP-Neu5Acm7G(5')pppAm-capped,polyadenylatedSARS-CoV-2 genomicRNA (plus strand)SARS-CoV-2gRNA:RTC:RNAprimer:RTCinhibitorsencapsidatedSARS-CoV-2 genomicRNA (plus strand)ATPpp1ab-nsp4 M H2OCTSL(114-288) PARP16 glycosylated-ACE2pp1ab-nsp8 N-glycan EH+pp1ab-nsp6 pp1ab-nsp3 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) m7G(5')pppAm-capped SARS-CoV-2 genomic RNA complement (minus strand) pp1ab-nsp3 NTPMAN1B1,EDEM2PPiN-glycan M pp1ab-nsp6 pp1a-nsp8 pp1ab-nsp13 pp1a-nsp4 pp1a-nsp3 pp1ab-nsp12 PARP4 m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) pp1ab-nsp7 glycosylated-ACE2 N-glycan M DDX5 mRNA6 minus strand pp1ab-nsp12 pp1ab-nsp12 MGAT5m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) ZCRB1:m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand)mRNA7b nsp8:MAP1LC3Bpp1ab-nsp14 Ub-3xPalmC-E pp1ab-nsp15 phospho-SUMO1-K62-ADPr-p-S177-Ncap ST3GAL4 7a m7G(5')pppAm-mRNA8 H2OTUSC3(1-348) pp1ab-nsp4 pp1a-nsp8H+Ub-3xPalmC-E Host Derived LipidBilayer Membranem7G(5')pppAm-mRNA5 pp1ab-nsp13 M pp1a-nsp6 N-glycan M PIK3C3 pp1ab-nsp14 H2ONVCPpp1ab-nsp10 pp1ab-nsp9N-glycan M pp1ab-nsp15 pp1abH+pp1a-nsp8 OST complexpp1a-3CLGANAB N-glycan pp1ab-nsp4 pp1ab-nsp12 pp1a-nsp4 pp1ab-nsp10 phospho-SUMO1-K62-ADPr-p-S177-Ncap SUMO1:C93-UBE2IMOGS 1011261269876, 1464714798154989816298914714, 38, 70, 146, 152...147101147981011, 7, 54, 103, 124...98479811471471261621629816214, 38, 70, 146, 152...12614, 38, 70, 146, 152...14, 38, 70, 146, 152...619814712641011621261471621261011264415710114, 38, 70, 146, 152...1479816216271162791479844714616212614312612614, 38, 70, 146, 152...16249898143