SARS-CoV-1 Infection (Homo sapiens)

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111, 161545423, 97, 132, 14693, 136, 17515, 782, 14, 43, 102, 1707515815116, 83, 106, 108, 135...2112634, 112, 14014916, 83, 106, 108, 135...419, 10916650, 77, 1297510788, 152166766, 52, 97, 116124911840, 9771, 13111111831, 2, 38, 43, 92...93, 13612812, 113, 114, 16913, 39, 98, 16311235, 56, 72, 89, 133...1737825, 79, 84, 87, 165...112, 1737, 9, 17, 26, 51...15224, 85, 17717329, 31, 44, 45, 55...75128, 15132, 422722, 14166, 90, 11131, 5520, 45, 49, 62, 128...1608953, 69, 122, 1421661111731267, 26, 66, 67, 90...16316, 83, 106, 108, 135...31, 55147, 6511211115111913, 41, 795950, 129128, 151789520, 128785, 30, 86, 99, 130...10483318, 1672, 14, 58, 81, 90...11228, 82, 110, 144, 162125639, 17, 36, 57, 60...2121173495973, 8013845, 128, 15931, 557412413711276668434, 112, 1408, 46, 93, 117, 148...autophagosomeGolgi membraneendoplasmic reticulum membraneGolgi lumendouble membrane vesicle viral factory outer membraneendocytic vesicle lumencytosolexocytic vesicleManually changed size and position of complexes for readability:endoplasmic reticulum-Golgi intermediate compartment membranenucleolus7a SUMO1-K62-ADPr-p-S177-Ncap UBC(533-608) Host Derived LipidBilayer MembraneMOGS pp1a-nsp8 NHC S-adenosyl-L-homocysteinecepharanthine ATPpp1a dimerm7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) pp1ab-nsp3 pp1ab-nsp4 pp1ab-nsp14 pp1ab-nsp14 NcapcomplexN-glycan-PALM-Spiketrimerpp1a-nsp10 nsp16:nsp10pp1a-nsp4 mefloquine mRNA3 minus strand pp1a-nsp6 complex N-glycan-PALM-Spike CTSL(114-288) pp1ab-nsp1-4 m7GpppA-mRNA8 H+SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp14 S3:M:E:encapsidatedSARScoronavirusgenomicRNA:7a:O-glycosyl3atetramer:glycosylated-ACE2pp1ab-nsp14 pp1a-nsp4 Ub-3xPalmC-E pp1ab-nsp12 pp1ab-nsp7 pp1ab-nsp15 Ub-3xPalmC-E UBE2I-G97-SUMO1 pp1ab-nsp10 Ub-3xPalmC-E O-glycosyl 3atetramerpp1ab-nsp6 RTC inhibitorspp1a-nsp3 m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) SUMO-p-Ncap dimerO-glycosyl 3atetramerNMPp-S177-NcapN-glycan M ST3GAL2 m7G(5')pppAm-capped,polyadenylated-mRNA9 pp1amRNA4 pp1ab-nsp6 pp1a-nsp7 pp1ab-nsp10 pp1ab-nsp6 7a O-glycosyl 3am7GpppA-mRNA5 m7G(5')pppAm-capped,polyadenylated mRNA3pp1ab-nsp13 m7G(5')pppAm-capped,polyadenylated mRNA6 M pp1a-nsp8 pp1ab-nsp8 O-glycosyl 3a pp1ab-nsp14 pp1ab-nsp14 UVRAG complexm7G(5')pppAm-mRNA8 nucleoside5'-diphosphate(3-)nsp8:MAP1LC3BS3:M:E:encapsidatedSARS coronavirusgenomicRNA:O-glycosyl 3atetramerm7G(5')pppAm-capped,polyadenylatedSARS-CoV-1 genomicRNA (plus strand)m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) m7G(5')pppAm-cappedSARS-CoV-1 genomicRNA complement(minus strand)CQ, HCQpp1a-nsp8 pp1ab-nsp8 pp1a-nsp8 PIK3R4 pp1ab-nsp8 3xPalmC-EMAP1LC3Bm7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) pp1a-nsp6 pp1a-nsp4 pp1ab-nsp14 H2ONTPpp1ab-nsp5 SARS-CoV-1 gRNAcomplement (minusstrand):RTC:RTCinhibitorsnsp3:nsp4complex N-glycan-PALM-Spike pp1a-nsp3 SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp6 pp1ab-nsp7 H2Opp1a-nsp4 pp1ab-nsp3 pp1a-nsp4 nsp9 dimerpp1ab-nsp15 m7G(5')pppAm-capped,polyadenylated mRNA5 pp1a-nsp10 pp1ab-nsp3 m7GpppA-mRNA2 SARS-CoV-1 gRNAcomplement (minusstrand):RTCpp1a-nsp6 SUMO1:C93-UBE2ImRNA2 minus strand pp1a-nsp7 Ub-3xPalmC-EpentamerPinsp3-4pp1ab-nsp4 GTPCTSL(292-333) CMPRPS27A(1-76) pp1ab-nsp8 NAD+m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) CTSL:CTSL inhibitorspp1a-nsp7 pp1ab-nsp12 pp1a-nsp10 pp1ab-nsp16 H+pp1ab-nsp16 N-glycan M 3aGSK3B UBC(229-304) S-adenosyl-L-methioninepp1ab-nsp10pp1ab-nsp3 nascent Spikecomplex N-glycan-PALM-Spike S2 Fragment pp1ab-nsp3 nsp8N-glycan M pp1a-nsp10 M trimmedN-glycan-PALM-Spikepp1ab-nsp12 pp1ab-nsp8 pp1a-nsp6 N-glycan nsp3-4H2OSARS-CoV-1 genomicRNA complement(minus strand)CHMP2B N-glycan pp1a-nsp3 pp1ab-nsp8 pp1ab-nsp10 M m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) m7G(5')pppAm-capped,polyadenylated mRNA4pp1ab-nsp8ZCRB1:SARS-CoV-1genomic RNA (plusstrand)ATPN-glycan M m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) pp1a-nsp7 pp1a-nsp4 m7G(5')pppAm-mRNA7 pp1a-nsp4 pp1ab-nsp12 ERalpha-glucosidasespp1a-nsp7Ub-3xPalmC-E m7GpppA-cappedSARS-CoV-1 genomicRNA (plus strand)pp1ab-nsp10 pp1a-nsp11Ub-3xPalmC-E CTSL inhibitorspp1ab-nsp3 pp1a-nsp3-4 ESCRT-IIIO-glycosyl 3atetramerpp1ab-nsp8 complex N-glycan-PALM-Spike MOGS SARS-CoV-1 gRNA:RTCCHMP7 UBB(77-152) O-glycosyl 3a SUMO1-K62-ADPr-p-S177-Ncappp1ab-nsp15 NHC N-glycan Mpp1a-nsp5H+Mbeta-D-glucoseSARS coronavirusgRNA:RTC:nascentRNA minus strandwith mismatchednucleotidepp1ab-nsp16 N-glycan M GSK3B:GSKipp1a-nsp1-47app1ab-nsp1 mRNA8 minus strand pp1ab-nsp15 pp1a-nsp8 O-glycosyl 3a ADPr-p-S177-NcapN-glycan pp1a-nsp4 pp1ab-nsp8 ATP8b nsp7:nsp8:nsp12:nsp14:nsp10complex N-glycan-PALM-Spike CHMP4B pp1a-nsp10 Host Derived Lipid Bilayer Membrane pp1ab-nsp3 m7GpppA-cappedSARS-CoV-1 genomicRNA complement(minus strand)m7G(5')pppAm-capped,polyadenylated mRNA2 PPipp1ab-nsp14 pp1a-nsp6 TMPRSS2 inhibitorspp1ab-nsp15 SUMO1-K62-ADPr-p-S177-Ncap m7G(5')pppAm-capped,polyadenylated mRNA2SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp10 pp1ab-nsp7 Ub-3xPalmC-Epentamerpp1ab-nsp13 m7G(5')pppAm-mRNA9 PARP14 SARS coronavirus nascent genomic RNA complement (minus strand) with mismatched 3' nucleotide pp1a-nsp6 pp1a-nsp10 ST6GALNAC3 cepharanthine mRNA5 H2Opp1a-nsp6 pp1a-nsp8 nsp10:nsp14pp1a-nsp10 nsp7:nsp8:nsp12:nsp14:nsp10:nsp13pp1ab-nsp13 pp1ab-nsp12 pp1ab-nsp4 CANXRB1SARScoronavirusgRNAwithsecondarystructure:RTC:nascent RNA minus strandpp1a-nsp6 mRNA8 SUMO1-K62-p-S177-Ncap dimerGSK3A ST6GAL1 TMPRSS2pp1a-nsp4 m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) pp1a-nsp8 N-glycan pp1a-nsp3 pp1a-nsp10SARS coronavirusgRNA with secondarystructure:RTCpp1ab-nsp9pp1ab-nsp4 pp1ab-nsp8 M pp1a-nsp3 pp1ab-nsp12 RNA primer pp1ab-nsp7SARS coronavirusgRNA:RTC:RNAprimer:RTCinhibitorspp1a-nsp10 ER-alphaglucosidases:ER-alpha glucosidase inhibitorspp1a-nsp8 m7G(5')pppAm-capped SARS-CoV-1 genomic RNA complement (minus strand) pp1ab-nsp7 pp1a-nsp6 pp1a-nsp4 pp1ab-nsp12 N-glycan pp1a-nsp3-4 7a nsp3RTCpp1a-nsp8 pp1a-nsp8 nascent Mnucleoside5'-diphosphate(3−)pp1ab-nsp15SUMO1-K62-ADPr-p-S177-Ncap SARS-CoV-1gRNA:RTC:nascentRNA minus strandATPnsp10PIK3C3 mRNA4 minus strand CHMP2A H2Opp1ab-nsp4 GTPpp1ab-nsp16 pp1a-nsp4 pp1a-nsp7 trimmed N-glycan-PALM-Spike pp1a-nsp8 nucleotide-sugarpp1ab-nsp12 nsp7:nsp8:nsp12:nsp14:nsp10:nsp13:nsp15nsp9N-glycan M nsp6pp1ab-nsp10 Ub-3xPalmC-E m7G(5')pppAm-SARS-CoV-1 plus strand subgenomic mRNAsmRNA7 pp1a-nsp8 nsp13:DDX5BECN1 Pipp1ab-nsp15 VCP1-deoxynojirimycin S-adenosyl-L-methionineH2Opp1a-nsp6 GALNT1PARP8 Ub-3xPalmC-Epp1a-nsp6 teicoplanin PPiS1:S2:M:E:7a:O-glycosyl 3atetramernsp3:nsp4:nsp6m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) UDP-GalNAcm7G(5')pppAm-capped SARS-CoV-1 genomic RNA complement (minus strand) NTPpp1ab-nsp13 SARS-CoV-1 plusstrand subgenomicmRNAsST3GAL3 VHL pp1ab-nsp10 UBB(153-228) Ub-3xPalmC-E m7G(5')pppAm-capped,polyadenylatedSARS-CoV-1 genomicRNA (plus strand)pp1ab-nsp15 sialyltransferasespp1a-nsp10 m7G(5')pppAm-capped,polyadenylatedSARS-CoV-1subgenomic mRNAs(plus strand)pp1a-nsp8ACE2pp1ab-nsp13 pp1a pp1ab-nsp13 TMPRSS2 Piencapsidated SARScoronavirus genomicRNApp1a-nsp10 m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) CoA-SHpp1ab-nsp8 PARP9 pp1ab-nsp16 O-glycosyl 3a 7a complex N-glycan-PALM-Spike S1 Fragment pp1ab-nsp16pp1ab-nsp8 a nucleotide sugarpp1ab-nsp5mRNA7 minus strand M PRKCSH m7GpppA-mRNA6 pp1a-nsp7 NTPO-glycosyl 3a pp1a-nsp8 pp1ab-nsp7 H2ON-glycan M nucleoside5'-diphosphate(3-)UBC(381-456) N-glycan MST6GALNAC2 N-glycan pp1ab-nsp3 a nucleotide sugarSUMO1-K62-ADPr-p-S177-Ncap S1:S2:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramerpp1a-nsp3 m7GpppA-mRNA7 Ub-3xPalmC-E UVRAG N-glycan Epp1a-nsp5 mRNA6 minus strand m7G(5')pppAm-capped,polyadenylated-mRNA9pp1abER-alpha-glucosidaseinhibitorsH+7a N-glycan nsp3RB1 glycosylated-ACE2:ACE2 inhibitorsADPZCRB1 pp1ab-nsp7 NHC pp1ab-nsp7 8b:MAP1LC3Bcomplex N-glycan-PALM-Spike pp1ab-nsp4 pp1ab-nsp12 PARP6 nsp7:nsp8:nsp12m7G(5')pppAm-mRNA6 pp1a-nsp2 H+glycosylated-ACE2GANAB MGAT1pp1ab-nsp7 RTC inhibitorsm7G(5')pppAm-capped,polyadenylated mRNA8 M pp1ab-nsp16 S3:M:E:encapsidatedSARS coronavirusgenomicRNA:7a:O-glycosyl3a tetramerM pp1ab-nsp8 complex N-glycan-PALM-Spike trimmed N-glycan-PALM-Spike N-glycan SpikeS3:M:E:encapsidatedSARScoronavirusgenomicRNA:7a:O-glycosyl3atetramer:glycosylated-ACE2pp1ab-nsp8 pp1ab-nsp4 N-glycan M S-adenosyl-L-homocysteineO-glycosyl 3a TMPRSS2:TMPRSS2inhibitorspp1a-nsp3 SARS-CoV-1 genomic RNA (plus strand) m7GpppA-mRNA9 PARP10 pp1ab-nsp13 mRNA2 pp1ab-nsp16 pp1ab-nsp13 nucleotide-sugarSUMO1-K62-ADPr-p-S177-Ncap m7G(5')pppAm-capped,polyadenylated mRNA5m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) PPiMAP1LC3Bglycosylated-ACE2 ZCRB1PARP4 pp1ab-nsp7 UBB(1-76) pp1ab-nsp6 camostat pp1ab-nsp16 pp1ab-nsp16 nsp4S-adenosyl-L-methioninePinucleoside5'-diphosphate(3−)m7G(5')pppAm-cappedSARS-CoV-1 genomicRNA (plus strand)CHMP4A pp1a-nsp10 pp1ab-nsp14 pp1ab-nsp10 PRKCSH UBC(457-532) H2OSARS-CoV-1gRNA:RTC:nascentRNA minusstrand:RTCinhibitorspp1ab-nsp14 pp1ab-nsp1-4pp1ab-nsp3 m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) mRNA9 minus strand m7GpppA-SARS-CoV-1plus strandsubgenomic mRNAsGANAB nsp7O-glycosyl 3a pp1a-nsp3 pp1ab-nsp6 mRNA3 pp1ab-nsp10 SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp13 S3:M:E:encapsidatedSARS coronavirusgenomic RNA:7a:O-glycosyl 3atetramernsp7:nsp8M pp1a-nsp10 pp1ab-nsp10 N-glycan nsp4ST6GALNAC4 pp1ab-nsp10 ADPUDP-N-acetyl-alpha-D-glucosamine(2−)SUMO1-K62-p-S177-Ncap dimerpp1a-nsp7 pp1ab-nsp16 pp1ab-nsp3 Ub-3xPalmC-E Ub-3xPalmC-E pp1a-nsp8 SUMO1-C93-UBE2I 7a pp1a-nsp10 pp1a-nsp7 NTPO-glycosyl 3am7G(5')pppAm-mRNA4 pp1ab-nsp4 CQ, HCQnsp6pp1a-nsp3 encapsidated SARScoronavirus genomicRNA (plus strand)O-glycosyl 3a palmitoyl-CoApp1ab-nsp7 N-glycan M PPiRNA primer pp1ab-nsp10 p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-Nm7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) SUMO1-K62-ADPr-p-S177-Ncap SUMO1-K62-ADPr-p-S177-Ncap pp1ab-nsp3 pp1ab-nsp13 pp1ab-nsp16 pp1ab-nsp6 UBC(153-228) CHMP3 pp1a-nsp1-4pp1ab-nsp4 pp1a-nsp7 PPiSARS-CoV-1 minusstrand subgenomicmRNAstrimmed unfoldedN-glycan Spikepp1ab-nsp2 N-glycanpp1ab-nsp3-4pp1ab-nsp8 pp1a-nsp7 pp1ab-nsp15 pp1ab-nsp7 3CLpdimer:α-Ketoamidespp1ab-nsp8 nsp2O-glycosyl 3a pp1a-nsp7 pp1a-nsp10 pp1ab-nsp4 pp1a-nsp3 pp1ab-nsp6 nsp1pp1a-nsp7 pp1ab-nsp4 SUMO-p-Ncapdimer:SARScoronavirus genomicRNApp1a-nsp1-4 SUMO1-K62-ADPr-p-S177-Ncap trimmedN-glycan-PALM-SpiketrimerUBC(609-684) S3:M:E:encapsidatedSARS coronavirusgenomicRNA:7a:O-glycosyl3a tetramerpp1ab-nsp12 nsp15:RB1nascent EO-glycosyl 3a pp1ab-nsp15 pp1ab-nsp7 PPipp1ab-nsp4 Mlattice:Eprotein:encapsidated SARS coronavirus genomic RNAm7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) pp1a-nsp3 3CLp dimerUBE2Ipp1ab-nsp13 pp1ab-nsp7 pp1ab-nsp15 M pp1ab-nsp16 pp1ab-nsp8 Npp1a-nsp8 SARS-CoV-1 nascent genomic RNA complement (minus strand) nsp16:VHLGSK3Bpp1ab-nsp15 trimmedN-glycan-PALM-Spiketrimerpp1ab-nsp15 mefloquine nsp1-4ADPpp1ab-nsp12 H2Opp1a-nsp3 pp1ab-nsp15 pp1a-nsp4 m7GpppA-mRNA4 8bpp1ab-nsp6 m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) pp1a-nsp3 pp1a-nsp6 Ub-3xPalmC-E pp1ab-nsp6 nsp15 hexamerSUMO1-K62-p-S177-Ncap dimerpp1ab-nsp3 pp1ab-nsp13 NAMH2Opp1ab-nsp14 PARPsACE2 inhibitorsSUMO-p-Ncap dimerUbm7G(5')pppAm-mRNA5 S3:M:E:encapsidatedSARS coronavirusgenomic RNA:7a:O-glycosyl 3atetramerATPtrimmed N-glycanSpikeDDX5ST3GAL1 pp1ab-nsp10 complex N-glycan-PALM-Spike pp1ab-nsp3 NTPpp1ab-nsp5 N-glycan M Ub-3xPalmC-E O-glycosyl 3a N-glycan pp1ab-nsp3-4 pp1ab-nsp4 3a:membranousstructureCTSL(114-288) pp1ab-nsp8 pp1a-nsp3 MAP1LC3B H+pp1ab-nsp15 GSK3M latticepp1ab-nsp7 pp1a-nsp8 pp1ab-nsp14 pp1a-nsp5 complex N-glycan-PALM-Spike H+SUMO1-K62-ADPr-p-S177-Ncap SUMO1-K62-ADPr-p-S177-Ncap SUMO1-K62-ADPr-p-S177-Ncap glycosylated-ACE27a UBC(1-76) pp1ab-nsp6 SUMO1-K62-ADPr-p-S177-Ncap m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand) pp1ab-nsp9 pp1ab-nsp6 pp1ab-nsp6 pp1ab-nsp3-4 GalNAc-O-3am7G(5')pppAm-mRNA3 O-glycosyl 3a pp1a-nsp6 SUMO1-K62-ADPr-p-S177-Ncap ST3GAL4 pp1a-nsp8 pp1a-nsp9CTSL(292-333) PPi9bpp1a-nsp7 m7G(5')pppAm-capped,polyadenylated mRNA3 pp1ab-nsp3 pp1a-nsp8 3aN-glycan nsp3pp1ab-nsp4 M pp1a-nsp6 complex N-glycan-PALM-Spike S2 Fragment SARS-CoV-1 nascent genomic RNA complement (minus strand) Cathepsin L1DDX5 pp1ab-nsp12 pp1ab-nsp10 VHLpp1ab-nsp9 pp1a-nsp6pp1a-nsp7 pp1ab-nsp12H+pp1ab-nsp8 pp1a-nsp6-11pp1ab-nsp7 NcapmRNA6 pp1a-nsp4 PPinsp5mRNA5 minus strand pp1a-nsp1 pp1ab-nsp10 pp1ab-nsp13 CQ2+, HCQ2+pp1a-nsp9 SARS coronavirusgRNA:RTC:RNA primerm7G(5')pppAm-mRNA2 7a pp1a-nsp3 pp1ab-nsp14 pp1a-nsp10 pp1ab-nsp13m7G(5')pppAm-capped,polyadenylated mRNA4 pp1a-nsp7 S-adenosyl-L-homocysteinepp1ab-nsp16 UBA52(1-76) pp1ab-nsp14 CHMP6 mRNA9 PPim7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) GSKipp1a-nsp4 m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) pp1a-nsp7 N-glycan pp1ab-nsp3 CMP-Neu5Acpp1a-nsp10 pp1ab-nsp12 pp1ab-nsp13 pp1ab-nsp10 pp1a-nsp10 SARS-CoV-1 genomicRNA (plus strand)UDPm7GpppA-mRNA3 pp1ab-nsp6GTPpp1ab-nsp6 CHMP4C pp1ab-nsp12 pp1ab-nsp10 UBC(305-380) SARS-CoV-1 nascent genomic RNA complement (minus strand) glycosylated-ACE2 pp1ab-nsp3 Npp1a-nsp4 m7G(5')pppAm-capped,polyadenylated mRNA7 MAP1LC3B N-glycan pp1ab-nsp4 pp1ab-nsp7 pp1a-nsp3 M pp1ab-nsp12 complex N-glycan-PALM-Spike S1 Fragment H2OUBC(77-152) pp1ab-nsp14pp1a-nsp7 α-Ketoamidespp1ab-nsp7 N-glycan M pp1a-nsp9 PARP16 pp1ab-nsp14 14921, 37, 64, 70, 104...14521, 37, 64, 70, 104...21, 37, 64, 70, 104...21, 37, 64, 70, 104...124951249114921, 37, 64, 70, 104...1248975847521, 37, 64, 70, 104...7521, 37, 64, 70, 104...18124489159759114521, 37, 64, 70, 104...21, 37, 64, 70, 104...75124601247535, 56, 72, 89, 133...75639121, 37, 64, 70, 104...1257314975919121, 37, 64, 70, 104...104, 1347321, 37, 64, 70, 104...9121, 37, 64, 70, 104...21, 37, 64, 70, 104...189121, 37, 64, 70, 104...1247521, 37, 64, 70, 104...9112421, 37, 64, 70, 104...7575919159919191124751241241241457512412412414512412421, 37, 64, 70, 104...124104