EGFR1 Signaling Pathway (Rattus norvegicus)

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1CYMitochondrionENENCYPMPMCYSumoylationPMPMERNUPMMAEnzyme complexEndoplasmic reticulumAcetylationCYGO(Protein-protein interaction)DDDemethylationCYCYNUMAPMNUActivationNUPMCytoplasmProteolytic cleavagePMCYNUPlasma membraneProteins in a complex interactionMADReaction through unknown mechanisms/moleculesCYGolgi apparatusCYCYNUMACYMAPMPMCYPMCYNUMAPMMolecule in the pathwayPMPMMACYPMMAPMCYCYNUCYExtracellularMAMethylationCYCYCYNUCYMANucleusCYDesumoylationMANURecruitmentCYInhibitionMANUECCYGlycosylationMADephosphorylationCYAutodephosphorylationPhosphorylationMAMACYMolecular associationMANUCYPMTranslocationReceptorMAEndosomeAutophosphorylationMANUCYControlGene SymbolCYAccession Number : NetPath 4; cellmap:4PMCYPMCYNUPMDeubiquitinationNUMTCYCYENNULigandCYMAPMDeacetylationNUNUPMPalmitoylationMAUbiquitinationCYNUNUMAEps15CskSh2d3cDusp1Sh3kbp1Eef1a2l1Map2k3Ptpn12Usp6nlAkt1Creb1SncaStat1Map3k2Mapk1Stat2YwhabGja1Arf4PxnPlcg2Map3k3Inppl1PTPN5Grb14CblbSos1Jak2Map2k7Mcf2Plec1Smad2Dok2EgfRps6ka1Mapk3HttMap3k2Rbbp7Pebp1Smad3Vav2Gab2Map3k4Errfi1Sp1Arf4Mta2Rac1EgfHdac1Zfp259Pld2Raf1Mapk14Map3k1Plcg2Atf1Smad2Epn1CebpaCav2Pik3r3Pik3c2bSmad3Tnk2APPLRps6ka5RalgdsPlscr1Reps2Krt8Nck2RalbGit1SOS2Stxbp1Jak1Reps1Rps6ka3RfxankShoc2Tcfcp2l2Map2k5Tnip1Gab1PRKAR1ASrcSh3gl2Pld1Krt18EgfrPak1NrasCamk2aDusp1Stat5aNck1PitpnaPrkcaTgif1Vav1CDC42KrasWNK1Raf1Stat1Arf4Eef1a2l1Rps6ka3Foxo1APPLGrb7MycMAPK7Ptpn6Pik3cgSh3gl3CrklAPPLStat2PIK3CACEACAM1Grb2Socs3Pik3cdBcar1Spry2Hip1Bcar1PrkciPlcg1Map2k2CblcPik3cbEgfrSh3gl2Shc1Pik3r1Stat1EgfrAsap1Abi1Ap2a1Cav1Map2k1Rgs16Grb10Mapk1Ripk1Foxo1Pik3r2Krt7EgfPrkcbJunArafEps15l1Snrpd2Rab5aRalbp1Krt17HIST3H3Rasa1CebpbPtprrElk1Ptpn6Appl2Ptpn11Ptk2bPrkczGab1EgfrSh3bgrlSh2d3cEps8Stat5bMap3k14PrkcgVav3Stxbp1Appl2Mapk8Zfp259CrkPtk6PrkcaWASLStat3Stat3Plcg1JundStat5aShc1Hat1Pld1Rps6ka2Elf3Ctnnd1Spry2Pkn2Casp9CblSin3aDnm1Prkd1Eppk1Socs1Elk4Map2k1Eps15ItchFosHrasElf3Stat3Ndufa13


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP437(r21600) with a 94% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, Westerhoff HV; ''Control of MAPK signalling: from complexity to what really matters.''; Oncogene, 2005 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
69392view18:58, 8 July 2013MaintBotUpdated to 2013 gpml schema
67177view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
41710view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
35718view23:29, 12 February 2010AlexanderPico
35438view11:35, 12 February 2010MichielAdded ref
34089view19:15, 9 December 2009MaintBotAutomatic update of empty xrefs
30926view00:36, 30 July 2009MaintBotConverted from Homo sapiens
20683view11:29, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:EGFR1 NetPath 4]] moved to [[Pathway:WP5]]: Moved to stable identifier