Deregulation of the Renin Angiotensin system by Sars-CoV infection (Mus musculus)

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Angiotensin IIAngiotensin Iangiotensin-(1-7)Angiotensinogen1111SARS-CoVSpike protein2. AngII accumulates as ACE2 no longer negatively regulates AngII productionLung injury1AT1RACE2ACEAT2R13. An increase in AT1R activity can lead to increased vascular permeability and lung injury11. ACE2 expression is downregulated by SARS-CoV Spike protein binding1angiotensin-(1-9)


The Spike protein of SARS-CoV will down regulate ACE2 which leads to deregulation of the Renin-Angiotensin-system. This deregulation can be the cause of lung injury that is linked to SARS-CoV infection. This work was done in a mouse model.

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  1. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM; ''''; , PubMed Europe PMC Scholia


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114109view08:00, 23 December 2020EgonwConverted a Label to a pathway DataNode
114021view15:21, 17 December 2020EgonwReplaced two ChEBI IDs for dizwitterions with IDs for their matching neutral form, the latter having mappings to Wikidata.
113646view18:21, 9 November 2020EgonwReplaced two old HMDB identifiers
112227view07:37, 4 October 2020EgonwReplaced the human genes with mouse gene identifiers.
112063view09:30, 18 September 2020DeSlMade textLabels more readable
112062view09:28, 18 September 2020DeSlUpdated unconencted lines to graphical lines; updated lit. ref.
111927view06:54, 11 September 2020EgonwModified title
111926view06:54, 11 September 2020EgonwRemoved the duplicate header
111925view06:53, 11 September 2020EgonwModified title
111600view06:57, 27 August 2020JdoijenModified description
111599view06:53, 27 August 2020JdoijenOntology Term : 'native cell' added !
111598view06:52, 27 August 2020JdoijenOntology Term : 'G protein mediated signaling pathway' added !
111597view06:51, 27 August 2020JdoijenOntology Term : 'viral infectious disease' added !
111596view06:50, 27 August 2020JdoijenNew pathway

External references


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NameTypeDatabase referenceComment
ACE2GeneProductENSMUSG00000015405 (Ensembl)
ACEGeneProductENSMUSG00000020681 (Ensembl)
AT1RGeneProductENSMUSG00000049115 (Ensembl)
AT2RGeneProductENSMUSG00000068122 (Ensembl)
Angiotensin IMetaboliteHMDB0061196 (HMDB)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
AngiotensinogenMetaboliteCHEBI:2720 (ChEBI)
Lung injuryPathway
angiotensin-(1-7)MetaboliteCHEBI:55438 (ChEBI)
angiotensin-(1-9)MetaboliteCHEBI:80128 (ChEBI)

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