p53 transcriptional gene network (Homo sapiens)

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1p53 transcriptional regulationAPAF1ApoptosisCell Cycle ArrestSenescenceDNA RepairFerroptosisMetabolism/AutophagyStem Cell FunctionTMEInvasion/MetastasisBAXFASMIR34APMAIP1TP53AIP1TRAF4PERPPIDD1TP53I3BBC3SIVA1TNFRSF10DYWHAB-208BTG2CCNG1CDKN1AGADD45AMIR34AMIR34BSMR3BRPRMZMAT3CDKN1ASERPINE1PMLDDB2ERCC5FANCCGADD45AXRCC5MGMTMLH1MSH2POLHPOLKRRM2BXPCSAT1SLC7A11GLS2CDKN1AMIR34AMIR200CSERPINB5CDKN1ALIFMIR34AMIR34B/CMIR145NANOGNOTCH1ACAD11ADORA2BALDH4A1CPT1CDRAM1FUCA1GLS2SLC2A1GPX1PRKAB1PRKAB2PTENSESN1SESN2TIGARTP53INP1ULK1ULK2ADGRB1CX3CL1ICAM1IRF5IRF9ISG15SERPINB5CCL2NCF2SERPINE1THBS1ULBP1ULBP2MIR34C


Description

The mechanisms underlying p53 tumor-suppressor function as gleaned from mouse models of genetic disruption to p53, its regulators and its targets (Kaiser 2017).

Quality Tags

Ontology Terms

 

Bibliography

  1. Kaiser AM, Attardi LD; ''Deconstructing networks of p53-mediated tumor suppression in vivo.''; Cell Death Differ, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
112233view17:48, 5 October 2020Khanspersadded identifiers to pathway nodes and updated color
112232view17:41, 5 October 2020KhanspersOntology Term : 'p53 signaling pathway' added !
112231view17:39, 5 October 2020Khanspersupdated literature reference format
111434view19:08, 9 August 2020AlexanderPicoModified description
111433view18:57, 9 August 2020AlexanderPicointeractions to graphical lines
111432view18:56, 9 August 2020AlexanderPicoidentified human orthologs; split MIR34B/C into two datanodes
111431view08:55, 8 August 2020EgonwFixed the Ensembl data source.
111412view05:08, 7 August 2020DiazfloreseModified title
111411view00:36, 7 August 2020DaisydxNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACAD11GeneProductENSG00000240303 (Ensembl)
ADGRB1GeneProductENSG00000181790 (Ensembl)
ADORA2BGeneProductENSG00000170425 (Ensembl)
ALDH4A1GeneProductENSG00000159423 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BTG2GeneProductENSG00000159388 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCNG1GeneProductENSG00000113328 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CPT1CGeneProductENSG00000169169 (Ensembl)
CX3CL1GeneProductENSG00000006210 (Ensembl)
Cell Cycle ArrestPathway
DDB2GeneProductENSG00000134574 (Ensembl)
DNA RepairPathwayWP4946 (WikiPathways)
DRAM1GeneProductENSG00000136048 (Ensembl)
ERCC5GeneProductENSG00000134899 (Ensembl)
FANCCGeneProductENSG00000158169 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FUCA1GeneProductENSG00000179163 (Ensembl)
FerroptosisPathwayWP4313 (WikiPathways)
GADD45AGeneProductENSG00000116717 (Ensembl)
GLS2GeneProductENSG00000135423 (Ensembl)
GPX1GeneProductENSG00000233276 (Ensembl)
ICAM1GeneProductENSG00000090339 (Ensembl)
IRF5GeneProductENSG00000128604 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
ISG15GeneProductENSG00000187608 (Ensembl)
Invasion/MetastasisPathway
LIFGeneProductENSG00000128342 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)
MIR145GeneProductENSG00000276365 (Ensembl)
MIR200CGeneProductENSG00000207713 (Ensembl)
MIR34AGeneProductENSG00000284357 (Ensembl)
MIR34B/CGeneProductENSG00000207811/ENSG00000207562 (Ensembl)
MIR34BGeneProductENSG00000207811 (Ensembl)
MIR34CGeneProductENSG00000207562 (Ensembl)
MLH1GeneProductENSG00000076242 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
Metabolism/AutophagyPathway
NANOGGeneProductENSG00000111704 (Ensembl)
NCF2GeneProductENSG00000116701 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PERPGeneProductENSG00000112378 (Ensembl)
PIDD1GeneProductENSG00000177595 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
POLHGeneProductENSG00000170734 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
RPRMGeneProductENSG00000177519 (Ensembl)
RRM2BGeneProductENSG00000048392 (Ensembl)
SAT1GeneProductENSG00000130066 (Ensembl)
SERPINB5GeneProductENSG00000206075 (Ensembl)
SERPINE1GeneProductENSG00000106366 (Ensembl)
SESN1GeneProductENSG00000080546 (Ensembl)
SESN2GeneProductENSG00000130766 (Ensembl)
SIVA1GeneProductENSG00000184990 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SMR3BGeneProductENSG00000171201 (Ensembl)
SenescencePathway
Stem Cell FunctionPathway
THBS1GeneProductENSG00000137801 (Ensembl)
TIGARGeneProductENSG00000078237 (Ensembl)
TMEPathway
TNFRSF10DGeneProductENSG00000173530 (Ensembl)
TP53AIP1GeneProductENSG00000120471 (Ensembl)
TP53I3GeneProductENSG00000115129 (Ensembl)
TP53INP1GeneProductENSG00000164938 (Ensembl) mouse ortholog: Trp53inp1
TRAF4GeneProductENSG00000076604 (Ensembl)
ULBP1GeneProductENSG00000111981 (Ensembl)
ULBP2GeneProductENSG00000131015 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
XPCGeneProductENSG00000154767 (Ensembl)
XRCC5GeneProductENSG00000079246 (Ensembl)
YWHAB-208GeneProductENST00000633979 (Ensembl)
ZMAT3GeneProductENSG00000172667 (Ensembl)
p53 transcriptional regulationPathway

Annotated Interactions

No annotated interactions

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