p53 transcriptional gene network (Homo sapiens)

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1ApoptosisAPAF1p53 transcriptional regulationCell Cycle ArrestSenescenceDNA RepairFerroptosisMetabolism/AutophagyStem Cell FunctionTMEInvasion/MetastasisBAXFASMIR34APMAIP1TP53AIP1TRAF4PERPPIDD1TP53I3BBC3SIVA1TNFRSF10DYWHAB-208BTG2CCNG1CDKN1AGADD45AMIR34AMIR34BSMR3BRPRMZMAT3CDKN1ASERPINE1PMLDDB2ERCC5FANCCGADD45AXRCC5MGMTMLH1MSH2POLHPOLKRRM2BXPCSAT1SLC7A11GLS2CDKN1AMIR34AMIR200CSERPINB5CDKN1ALIFMIR34AMIR34B/CMIR145NANOGNOTCH1ACAD11ADORA2BALDH4A1CPT1CDRAM1FUCA1GLS2SLC2A1GPX1PRKAB1PRKAB2PTENSESN1SESN2TIGARTP53INP1ULK1ULK2ADGRB1CX3CL1ICAM1IRF5IRF9ISG15SERPINB5CCL2NCF2SERPINE1THBS1ULBP1ULBP2MIR34C


Description

The mechanisms underlying p53 tumor-suppressor function as gleaned from mouse models of genetic disruption to p53, its regulators and its targets (Kaiser 2017).

Quality Tags

Ontology Terms

 

Bibliography

  1. Alyssa M Kaiser, Laura D Attardi; ''Deconstructing networks of p53-mediated tumor suppression in vivo ''; , 2017

History

View all...
CompareRevisionActionTimeUserComment
111434view19:08, 9 August 2020AlexanderPicoModified description
111433view18:57, 9 August 2020AlexanderPicointeractions to graphical lines
111432view18:56, 9 August 2020AlexanderPicoidentified human orthologs; split MIR34B/C into two datanodes
111431view08:55, 8 August 2020EgonwFixed the Ensembl data source.
111412view05:08, 7 August 2020DiazfloreseModified title
111411view00:36, 7 August 2020DaisydxNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACAD11GeneProductENSG00000240303 (Ensembl)
ADGRB1GeneProductENSG00000181790 (Ensembl)
ADORA2BGeneProductENSG00000170425 (Ensembl)
ALDH4A1GeneProductENSG00000159423 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
ApoptosisPathway
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BTG2GeneProductENSG00000159388 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCNG1GeneProductENSG00000113328 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CPT1CGeneProductENSG00000169169 (Ensembl)
CX3CL1GeneProductENSG00000006210 (Ensembl)
Cell Cycle ArrestPathway
DDB2GeneProductENSG00000134574 (Ensembl)
DNA RepairPathway
DRAM1GeneProductENSG00000136048 (Ensembl)
ERCC5GeneProductENSG00000134899 (Ensembl)
FANCCGeneProductENSG00000158169 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FUCA1GeneProductENSG00000179163 (Ensembl)
FerroptosisPathway
GADD45AGeneProductENSG00000116717 (Ensembl)
GLS2GeneProductENSG00000135423 (Ensembl)
GPX1GeneProductENSG00000233276 (Ensembl)
ICAM1GeneProductENSG00000090339 (Ensembl)
IRF5GeneProductENSG00000128604 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
ISG15GeneProductENSG00000187608 (Ensembl)
Invasion/MetastasisPathway
LIFGeneProductENSG00000128342 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)
MIR145GeneProductENSG00000276365 (Ensembl)
MIR200CGeneProductENSG00000207713 (Ensembl)
MIR34AGeneProductENSG00000284357 (Ensembl)
MIR34B/CGeneProductENSG00000207811/ENSG00000207562 (Ensembl)
MIR34BGeneProductENSG00000207811 (Ensembl)
MIR34CGeneProductENSG00000207562 (Ensembl)
MLH1GeneProductENSG00000076242 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
Metabolism/AutophagyPathway
NANOGGeneProductENSG00000111704 (Ensembl)
NCF2GeneProductENSG00000116701 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PERPGeneProductENSG00000112378 (Ensembl)
PIDD1GeneProductENSG00000177595 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
POLHGeneProductENSG00000170734 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
RPRMGeneProductENSG00000177519 (Ensembl)
RRM2BGeneProductENSG00000048392 (Ensembl)
SAT1GeneProductENSG00000130066 (Ensembl)
SERPINB5GeneProductENSG00000206075 (Ensembl)
SERPINE1GeneProductENSG00000106366 (Ensembl)
SESN1GeneProductENSG00000080546 (Ensembl)
SESN2GeneProductENSG00000130766 (Ensembl)
SIVA1GeneProductENSG00000184990 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SMR3BGeneProductENSG00000171201 (Ensembl)
SenescencePathway
Stem Cell FunctionPathway
THBS1GeneProductENSG00000137801 (Ensembl)
TIGARGeneProductENSG00000078237 (Ensembl)
TMEPathway
TNFRSF10DGeneProductENSG00000173530 (Ensembl)
TP53AIP1GeneProductENSG00000120471 (Ensembl)
TP53I3GeneProductENSG00000115129 (Ensembl)
TP53INP1GeneProductENSG00000164938 (Ensembl) mouse ortholog: Trp53inp1
TRAF4GeneProductENSG00000076604 (Ensembl)
ULBP1GeneProductENSG00000111981 (Ensembl)
ULBP2GeneProductENSG00000131015 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
XPCGeneProductENSG00000154767 (Ensembl)
XRCC5GeneProductENSG00000079246 (Ensembl)
YWHAB-208GeneProductENST00000633979 (Ensembl)
ZMAT3GeneProductENSG00000172667 (Ensembl)
p53 transcriptional regulationPathway

Annotated Interactions

No annotated interactions

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