NO metabolism in cystic fibrosis (Homo sapiens)

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21Urinary excretionL-ArginineL-arginine residuePRMT1NOS2Carboxyl anhydrasePRMT6Nω,Nω- dimethyl- L- arginineDDAH1NOS3NOS1 DDAH2PRMT7PRMT8PRMT3PRMT5CARM1PRMT2NO-signalingNitric oxideNitrogen dioxideNitrooxidanylDimethylamineNω,N'ω-dimethyl-L-arginineNω,Nω-dimethyl-L-arginine residueProteases


This pathway describes the NO metabolism in cystic fibrosis (CF) and is based on Figure 1 of Brinkmann et al. 2020.

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Ontology Terms



  1. Zhao H, Xu X, Ujiie K, Star RA, Muallem S; ''Transport and interaction of nitrogen oxides and NO2 with CO2-HCO3- transporters in pancreatic acini.''; Am J Physiol, 1994 PubMed Europe PMC Scholia
  2. Brinkmann F, Hanusch B, Ballmann M, Mayorandan S, Bollenbach A, Chobanyan-Jürgens K, Jansen K, Schmidt-Choudhury A, Derichs N, Tsikas D, Lücke T; ''Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results.''; J Clin Med, 2020 PubMed Europe PMC Scholia


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111131view13:43, 16 July 2020Fehrhartfixed unconnected line
111095view13:43, 9 July 2020FehrhartModified description
111094view13:42, 9 July 2020FehrhartOntology Term : 'disease pathway' added !
111093view13:41, 9 July 2020FehrhartOntology Term : 'cystic fibrosis' added !
111092view13:41, 9 July 2020FehrhartOntology Term : 'nitric oxide mediated signaling pathway' added !
111091view13:39, 9 July 2020FehrhartNew pathway

External references


View all...
NameTypeDatabase referenceComment
CARM1GeneProductENSG00000142453 (Ensembl)
Carboxyl anhydraseGeneProductPF00194 (Pfam)
DDAH1GeneProduct23576 (Entrez Gene)
DDAH2GeneProduct23564 (Entrez Gene)
DimethylamineMetabolite17170 (ChEBI) DMA
L-ArginineMetabolite16467 (ChEBI)
L-arginine residueMetabolite29952 (ChEBI)
NO-signalingPathwayWP1850 (WikiPathways)
NOS1 GeneProductENSG00000089250 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
NOS3GeneProductENSG00000164867 (Ensembl)
Nitric oxideMetabolite16480 (ChEBI)
Nitrogen dioxideMetabolite33101 (ChEBI)
NitrooxidanylMetabolite29329 (ChEBI)
Nω,N'ω-dimethyl-L-arginineMetabolite25682 (ChEBI) SDMA
Nω,Nω- dimethyl- L- arginineMetabolite17929 (ChEBI) ADMA
Nω,Nω-dimethyl-L-arginine residueMetabolite61896 (ChEBI)
PRMT1GeneProductENSG00000126457 (Ensembl)
PRMT2GeneProductENSG00000160310 (Ensembl)
PRMT3GeneProductENSG00000185238 (Ensembl)
PRMT5GeneProductENSG00000100462 (Ensembl)
PRMT6GeneProductENSG00000198890 (Ensembl)
PRMT7GeneProductENSG00000132600 (Ensembl)
PRMT8GeneProductENSG00000111218 (Ensembl)

Annotated Interactions

No annotated interactions

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