DNA Repair Pathways Full Network (Homo sapiens)

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2, 5DNA Repair PathwaysMismatch Repair (MMR)Nucleotide Excision Repair (NER)Base Excision Repair (BER)Homologous Recombination Repair (HR)Non-Homologous End Joining (NHEJ)Methyl-Guanine DNA Methyltransferase (MGMT)Fanconi Anemia Pathway (FA)3Trans-Lesion Synthesis (TLS)1ATMATRAlternative End-Joining (Alt-EJ)4RPA1RPA2RPA3RFC1MSH2MSH3MSH6RFC2RFC3RFC4RFC5EXO1PCNAMLH1PMS2POLEPOLE2POLE3POLE4POLD1POLD2POLD3POLD4LIG1RBX1DDB1DDB2CUL4ACUL4BXPCXPARAD23ARAD23BCETN2ERCC1ERCC2ERCC3ERCC4ERCC5ERCC6ERCC8CDK7MNAT1CCNHGTF2H5GTF2H2GTF2H1GTF2H3GTF2H4RPA1RPA2RPA3POLEPOLE2POLE3POLE4POLD1POLD2POLD3POLD4PCNARFC1RFC2RFC3RFC4RFC5LIG1XRCC4XRCC5XRCC6WRNPRKDCDCLRE1CPOLMPOLLLIG4NHEJ1OGG1NTHL1NEIL2NEIL3APEX1APEX2PNKPXRCC1POLBPOLLPARP1PARP2HMGB1LIG1LIG3UNGSMUG1MUTYHMPGMBD4TDGPOLD1POLD2POLD3POLD4PCNAPOLEPOLE2POLE3POLE4FEN1NBNMRE11ARPA1BRCA2RAD50RAD51RAD52RAD54BPOLD1POLD2POLD3POLD4FANCAFANCD2FANCCFANCNFANCMFANCLFANCJFANCIFANCGFANCFFANCEFANCBFAAP24FAAP100MHF1MHF2FAN1USP1UAF1ATRCHEK1H2AXBRCA1BRCA2RAD51CLIG4LIG1XRCC4XRCC5XRCC6PRKDCMRE11RAD50XRS2TERF2RAP1AATMATRREV3LREV1POLHPOLIPOLKPCNAMGMT


Description

DNA Repair Pathways (Full Network)

Quality Tags

Ontology Terms

 

Bibliography

  1. Myron F. Goodman, Roger Woodgate; ''Translesion DNA Polymerases ''; , 2013
  2. Apostolos Klinakis, Dimitris Karagiannis, Theodoros Rampias; ''''; ,
  3. Younghoon Kee, Alan D. D’Andrea; ''Expanded roles of the Fanconi anemia pathway in preserving genomic stability ''; , 2020
  4. Anabelle Decottignies; ''Alternative end-joining mechanisms: a historical perspective''; , 2013
  5. Mateusz Kciuk, Karol Bukowski, Beata Marciniak, Renata Kontek; ''''; , 2020

History

View all...
CompareRevisionActionTimeUserComment
111386view12:22, 5 August 2020Marvin M2Ontology Term : 'DNA repair pathway' added !
111171view13:43, 21 July 2020EgonwAdded the alternative gene name as comment, as it is not an Ensembl identifier.
111170view13:41, 21 July 2020EgonwReplaced with a human gene: http://www.ensembl.org/Mus_musculus/Gene/Compara_Ortholog/Alignment?db=core;g=ENSMUSG00000031928;g1=ENSG00000020922;hom_id=466173121;r=9:14784654-14837123
111106view20:41, 10 July 2020DiazfloreseModified title
111088view22:36, 7 July 2020DaisydxNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
APEX1GeneProductENSG00000100823 (Ensembl)
APEX2GeneProductENSG00000169188 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
Alternative End-Joining (Alt-EJ)
BRCA1GeneProductENSG00000012048 (Ensembl)
BRCA2GeneProductENSG00000139618 (Ensembl)
Base Excision Repair (BER)Wikipathway reference: WP4752
CCNHGeneProductENSG00000134480 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CETN2GeneProductENSG00000147400 (Ensembl)
CHEK1GeneProductENSG00000149554 (Ensembl)
CUL4AGeneProductENSG00000139842 (Ensembl)
CUL4BGeneProductENSG00000158290 (Ensembl)
DCLRE1CGeneProductENSG00000152457 (Ensembl)
DDB1GeneProductENSG00000167986 (Ensembl)
DDB2GeneProductENSG00000134574 (Ensembl)
DNA Repair PathwaysPathway
ERCC1GeneProductENSG00000012061 (Ensembl)
ERCC2GeneProductENSG00000104884 (Ensembl)
ERCC3GeneProductENSG00000163161 (Ensembl)
ERCC4GeneProductENSG00000175595 (Ensembl)
ERCC5 GeneProductENSG00000134899 (Ensembl)
ERCC6GeneProductENSG00000225830 (Ensembl)
ERCC8GeneProductENSG00000049167 (Ensembl)
EXO1GeneProductENSG00000174371 (Ensembl)
FAAP100GeneProductENSG00000185504 (Ensembl)
FAAP24GeneProductENSG00000131944 (Ensembl)
FAN1GeneProductENSG00000198690 (Ensembl)
FANCAGeneProductENSG00000187741 (Ensembl)
FANCBGeneProductENSG00000181544 (Ensembl)
FANCCGeneProductENSG00000158169 (Ensembl)
FANCD2GeneProductENSG00000144554 (Ensembl)
FANCEGeneProductENSG00000112039 (Ensembl)
FANCFGeneProductENSG00000183161 (Ensembl)
FANCGGeneProductENSG00000221829 (Ensembl)
FANCIGeneProductENSG00000140525 (Ensembl)
FANCJGeneProductENSG00000136492 (Ensembl) BRIP1
FANCLGeneProductENSG00000115392 (Ensembl)
FANCMGeneProductENSG00000187790 (Ensembl)
FANCNGeneProductENSG00000083093 (Ensembl) PALB2
FEN1GeneProductENSG00000168496 (Ensembl)
Fanconi Anemia Pathway (FA)
GTF2H1GeneProductENSG00000110768 (Ensembl)
GTF2H2GeneProductENSG00000145736 (Ensembl)
GTF2H3GeneProductENSG00000111358 (Ensembl)
GTF2H4GeneProductENSG00000213780 (Ensembl)
GTF2H5GeneProductENSG00000272047 (Ensembl)
H2AXGeneProductENSG00000188486 (Ensembl)
HMGB1GeneProductENSG00000189403 (Ensembl)
Homologous Recombination Repair (HR)Wikipathway reference: WP186
LIG1GeneProductENSG00000105486 (Ensembl)
LIG3GeneProductENSG00000005156 (Ensembl)
LIG4GeneProductENSG00000174405 (Ensembl)
MBD4GeneProductENSG00000129071 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)
MHF1GeneProductENSG00000175279 (Ensembl) CENPS
MHF2GeneProductENSG00000169689 (Ensembl) CENPX
MLH1GeneProductENSG00000076242 (Ensembl)
MNAT1GeneProductENSG00000020426 (Ensembl)
MPGGeneProductENSG00000103152 (Ensembl)
MRE11AGeneProductENSG00000020922 (Ensembl)
MRE11GeneProductENSG00000020922 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MSH3GeneProductENSG00000113318 (Ensembl)
MSH6GeneProductENSG00000116062 (Ensembl)
MUTYHGeneProductENSG00000132781 (Ensembl)
Methyl-Guanine DNA Methyltransferase (MGMT)
Mismatch Repair (MMR)Wikipathway reference: WP531
NBNGeneProductENSG00000104320 (Ensembl)
NEIL2GeneProductENSG00000154328 (Ensembl)
NEIL3GeneProductENSG00000109674 (Ensembl)
NHEJ1GeneProductENSG00000187736 (Ensembl)
NTHL1GeneProductENSG00000065057 (Ensembl)
Non-Homologous End Joining (NHEJ)Wikipathway reference: WP438
Nucleotide Excision Repair (NER)Wikipathway reference: WP4753
OGG1GeneProductENSG00000114026 (Ensembl)
PARP1GeneProductENSG00000143799 (Ensembl)
PARP2GeneProductENSG00000129484 (Ensembl)
PCNAGeneProductENSG00000132646 (Ensembl)
PMS2GeneProductENSG00000122512 (Ensembl)
PNKPGeneProductENSG00000039650 (Ensembl)
POLBGeneProductENSG00000070501 (Ensembl)
POLD1GeneProductENSG00000062822 (Ensembl)
POLD2GeneProductENSG00000106628 (Ensembl)
POLD3GeneProductENSG00000077514 (Ensembl)
POLD4GeneProductENSG00000175482 (Ensembl)
POLE2GeneProductENSG00000100479 (Ensembl)
POLE3GeneProductENSG00000148229 (Ensembl)
POLE4GeneProductENSG00000115350 (Ensembl)
POLEGeneProductENSG00000177084 (Ensembl)
POLHGeneProductENSG00000170734 (Ensembl)
POLIGeneProductENSG00000101751 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
POLLGeneProductENSG00000166169 (Ensembl)
POLMGeneProductENSG00000122678 (Ensembl)
PRKDCGeneProductENSG00000253729 (Ensembl)
RAD23AGeneProductENSG00000179262 (Ensembl)
RAD23BGeneProductENSG00000119318 (Ensembl)
RAD50GeneProductENSG00000113522 (Ensembl)
RAD51 GeneProductENSG00000051180 (Ensembl)
RAD51CGeneProductENSG00000108384 (Ensembl)
RAD52GeneProductENSG00000002016 (Ensembl)
RAD54BGeneProductENSG00000197275 (Ensembl)
RAP1AGeneProductENSG00000116473 (Ensembl)
RBX1GeneProductENSG00000100387 (Ensembl)
REV1GeneProductENSG00000135945 (Ensembl)
REV3LGeneProductENSG00000009413 (Ensembl)
RFC1GeneProductENSG00000035928 (Ensembl)
RFC2GeneProductENSG00000049541 (Ensembl)
RFC3GeneProductENSG00000133119 (Ensembl)
RFC4GeneProductENSG00000163918 (Ensembl)
RFC5 GeneProductENSG00000111445 (Ensembl)
RPA1GeneProductENSG00000132383 (Ensembl)
RPA2GeneProductENSG00000117748 (Ensembl)
RPA3GeneProductENSG00000106399 (Ensembl)
SMUG1GeneProductENSG00000123415 (Ensembl)
TDGGeneProductENSG00000139372 (Ensembl)
TERF2GeneProductENSG00000132604 (Ensembl)
Trans-Lesion Synthesis (TLS)
UAF1GeneProductENSG00000114742 (Ensembl) WDR48
UNGGeneProductENSG00000076248 (Ensembl)
USP1GeneProductENSG00000162607 (Ensembl)
WRNGeneProductENSG00000165392 (Ensembl)
XPAGeneProductENSG00000136936 (Ensembl)
XPCGeneProductENSG00000154767 (Ensembl)
XRCC1GeneProductENSG00000073050 (Ensembl)
XRCC4GeneProductENSG00000152422 (Ensembl)
XRCC5GeneProductENSG00000079246 (Ensembl)
XRCC6GeneProductENSG00000196419 (Ensembl)
XRS2GeneProductS. Cerevisiae: YDR369C

Annotated Interactions

No annotated interactions

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