Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome (Homo sapiens)

From WikiPathways

Jump to: navigation, search
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)AutophagyNecrosisDeguelinDecreased proximal tubule vectorial transportDecreased mitochondrial oxidative phosphorylationApoptosisFerroptosisAssembly of mitochondrial complex IOxidative stress responseImpaired proteostasisUnfolded Protein ResponseRotenoneKE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)KE1477: Decrease, OXPHOSKE1562: Decreased Na/K ATPase activityKE1563: Decreased proximal tubular vectorial transportKE1564: Chemical induced Fanconi syndromeKE55: N/A, Cell injury/deathKE889: Impaired, Proteostasis


Description

This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome (https://aopwiki.org/aops/276). All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
118493view08:55, 28 May 2021FinterlyIn Previous edit, replaced DataNode type "Stressor" and "Key Event" with "Event" (Comment)
118492view08:49, 28 May 2021FinterlyReplaced
116640view11:29, 9 May 2021EweitzModified title
115232view07:21, 6 February 2021EgonwRedirected a pathway node, after deletion of the previous linked pathway
111509view09:57, 21 August 2020Marvin M2ungrouped groups for better network merging
111508view09:53, 21 August 2020Marvin M2Aligned layout better
111506view09:44, 21 August 2020Marvin M2Changed connections in groups to test for merging
111424view11:23, 7 August 2020Marvin M2Ontology Term : 'altered metabolic pathway' added !
111077view11:36, 6 July 2020Marvin M2Modified description
111076view11:27, 6 July 2020Marvin M2Ontology Term : 'Fanconi syndrome' added !
111075view11:26, 6 July 2020Marvin M2
111074view11:23, 6 July 2020Marvin M2Modified description
111073view11:16, 6 July 2020Marvin M2
111072view11:13, 6 July 2020Marvin M2
111071view11:12, 6 July 2020Marvin M2
111070view11:10, 6 July 2020Marvin M2
111069view11:03, 6 July 2020Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ApoptosisPathwayWP1772 (WikiPathways)
Assembly of mitochondrial complex IPathwayWP4324 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
Decreased mitochondrial oxidative phosphorylationPathwayWP111 (WikiPathways)
Decreased proximal tubule vectorial transportPathwayWP4917 (WikiPathways)
DeguelinMetaboliteCHEBI:4357 (ChEBI)
FerroptosisPathwayWP4313 (WikiPathways)
Impaired proteostasisPathwayWP4918 (WikiPathways)
KE1477: Decrease, OXPHOSEvent1477 (AOP-Wiki KE)
KE1562: Decreased Na/K ATPase activity Event1562 (AOP-Wiki KE)
KE1563: Decreased proximal tubular vectorial transport Event1563 (AOP-Wiki KE)
KE1564: Chemical induced Fanconi syndrome Event1564 (AOP-Wiki KE)
KE55: N/A, Cell injury/death Event55 (AOP-Wiki KE)
KE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)Event887 (AOP-Wiki KE)
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)Event888 (AOP-Wiki KE)
KE889: Impaired, Proteostasis Event889 (AOP-Wiki KE)
NecrosisPathwayWP5022 (WikiPathways)
Oxidative stress responsePathwayWP3941 (WikiPathways)
RotenoneEvent50 (AOP-Wiki Stressor)
Unfolded Protein ResponsePathwayWP4925 (WikiPathways)

Annotated Interactions

No annotated interactions

Personal tools