The role of GPR143 in melanocytes and retinal pigment epithelium cells (Homo sapiens)

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277109376, 11741398, 1512, 161, 7, 1314543148, 154779, 1210, 1397716L-DOPAPMELDHICAPPiL-tyrosineDCTMC1RTYRP1MITFSERPINF1IQPMELITPR1DCTDopachromePLCB2ADCY2GNA15PRKACBGPR143GPR143ADCY4PLCB1DQGNASTYRP1ARRB1DAGcAMPCREB1IP3PRKACATyrosinasePOMCATPCa2+MLANAPLCB3VEGFAADCY9PRKCBASIPARRB2TYRDopamineGNAQPLCB4PRKACG4DHI7MART-1MITFCREB1


Description

A model demonstrating the place of the GPR143 gene in the pathogenesis of ocular albinism type 1. The latter shows the interactions between GPR143 and the different genes responsible for melanogenesis as well as growth factors such as SERPINF1 and VEGF in melanocytes or the retinal pigment epithelium.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
113647view18:24, 9 November 2020EgonwReplaced an old HMDB identifier
111385view12:20, 5 August 2020Marvin M2Ontology Term : 'retinal pigment epithelial cell' added !
111384view12:20, 5 August 2020Marvin M2Ontology Term : 'melanocyte' added !
111383view12:19, 5 August 2020Marvin M2Ontology Term : 'ocular albinism' added !
111027view05:05, 1 July 2020EgonwReplaced secondary ChEBI identifiers with primairy identifiers.
111001view14:35, 26 June 2020Victor MarxAddition of a new mtabolite (Dopamine) / New title
111000view12:53, 26 June 2020Victor MarxThe MC1R protein databased was change from Swissprot to TrEMBL
110998view07:15, 26 June 2020FehrhartGPR143 change
110945view15:14, 23 June 2020Victor MarxNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADCY2GeneProductENSG00000078295 (Ensembl)
ADCY4GeneProductENSG00000129467 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
ARRB1GeneProductENSG00000137486 (Ensembl)
ARRB2GeneProductENSG00000141480 (Ensembl)
ASIPGeneProductENSG00000101440 (Ensembl)
ATPMetaboliteCHEBI:30616 (ChEBI)
CREB1GeneProductENSG00000118260 (Ensembl) phosphorylated by PRKACA/B/G
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DAGMetaboliteCHEBI:17815 (ChEBI)
DCTGeneProductENSG00000080166 (Ensembl)
DCTProteinP40126 (Uniprot-TrEMBL)
DHICAMetaboliteCHEBI:2003 (ChEBI)
DHIMetaboliteCHEBI:27404 (ChEBI)
DQMetaboliteCHEBI:16852 (ChEBI)
Dopachrome MetaboliteHMDB0012931 (HMDB)
DopamineMetaboliteCHEBI:18243 (ChEBI)
GNA15GeneProductENSG00000060558 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
GNASGeneProductENSG00000087460 (Ensembl)
GPR143GeneProductENSG00000101850 (Ensembl)
GPR143ProteinP51810 (Uniprot-TrEMBL)
IP3MetaboliteCHEBI:18228 (ChEBI)
IQMetaboliteCHEBI:27406 (ChEBI)
ITPR1GeneProductENSG00000150995 (Ensembl) https://www.wikipathways.org/index.php/Pathway:WP35
L-DOPAMetaboliteCHEBI:15765 (ChEBI)
L-tyrosineMetaboliteCHEBI:17895 (ChEBI)
MART-1ProteinQ16655 (Uniprot-TrEMBL)
MC1RProteinQ01726 (Uniprot-TrEMBL)
MITFGeneProductENSG00000187098 (Ensembl)
MITFProteinO75030 (Uniprot-TrEMBL)
MLANAGeneProductENSG00000120215 (Ensembl)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductPLCB4 (HGNC)
PMELGeneProductENSG00000185664 (Ensembl)
PMELProteinP40967 (Uniprot-TrEMBL)
POMCGeneProductENSG00000115138 (Ensembl)
PPiMetaboliteCHEBI:29888 (ChEBI)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
TYRGeneProductENSG00000077498 (Ensembl)
TYRP1GeneProductENSG00000107165 (Ensembl)
TYRP1ProteinP17643 (Uniprot-TrEMBL)
TyrosinaseProteinP14679 (Uniprot-TrEMBL)
VEGFAGeneProductENSG00000112715 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)

Annotated Interactions

No annotated interactions

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