Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)

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Autophagosome/Phospho(S/T) siteHOPS COMPLEXPhagophoreAccumulation of autophagy receptors Legendcargo sequestrationAutophagy receptors MLST8ATG16LMAP1LC3BMTORATG5ORF3FIP200AKT1GABARAPL2ATG9AATG4ULK1NRB1ATG12VPS33AVPS18SQSTM1VPS36AKTS1HOPS COMPLEXCALCOCO2DEPTORRPTORVPS16ATG7TSC2TAX1BP1P70S6KATG13RPS6VPS41ORF3RAB7AVPS11GSK3ATG3OPTNLARP1PKMAMPKSNAREsRHEBmTORC1 S361K82K435K24K143S203S735S1347T525T1162K74S766S638K149S272S738T269K46S479S202S477S18K281K97K157S240S355 S366S238LysosomeAutophagolysosomeFusionLate endosomeUbiqutination (K) siteBindingInteractionUpregulationSARS-CoV-2 proteinInhibitionNSP61


Description

Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2, derived from the network diffusion model and overlaid with the changes in protein levels, ubiquitination and phosphorylation induced by SARS-CoV-2 infection.

Quality Tags

Ontology Terms

 

Bibliography

  1. Alexey Stukalov, Virginie Girault, Vincent Grass, Valter Bergant, Ozge Karayel, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, Sabri M. Hamad, Antonio Piras, Maria Tanzer, Fynn M. Hansen, Thomas Enghleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro, Matthias Mann, Andreas Pichlmair; ''Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV''; https://doi.org/10.1101/2020.06.17.156455, 2020

History

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CompareRevisionActionTimeUserComment
111028view06:22, 1 July 2020EgonwUpdated the UniProt data source
110916view04:32, 21 June 2020Rex D A BOntology Term : 'altered autophagy pathway' added !
110915view04:30, 21 June 2020Rex D A BOntology Term : 'infectious disease pathway' added !
110914view04:18, 21 June 2020Rex D A BModified description
110913view04:17, 21 June 2020Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
GeneProduct
AKT1ProteinP31749 (Uniprot-TrEMBL)
AKTS1GeneProduct
AMPKProtein5563 (NCBI Protein)
ATG12Protein9140 (NCBI Protein)
ATG13Protein9776 (NCBI Protein)
ATG16LProtein55054 (NCBI Protein)
ATG3Protein64422 (NCBI Protein)
ATG4GeneProduct
ATG5Protein9474 (NCBI Protein)
ATG7Protein10533 (NCBI Protein)
ATG9AProtein79065 (NCBI Protein)
CALCOCO2Protein10241 (NCBI Protein)
DEPTORProtein64798 (NCBI Protein)
FIP200Protein9821 (NCBI Protein)
GABARAPL2Protein11345 (NCBI Protein)
GSK3ProteinP31749 (NCBI Protein)
HOPS COMPLEXGeneProductHOPS COMPLEX
LARP1GeneProductLARP1
MAP1LC3BGeneProduct81631 (NCBI Protein)
MLST8Protein64223 (NCBI Protein)
MTORProtein2475 (NCBI Protein)
NRB1GeneProduct
NSP6ProteinYP_009725302 (NCBI Protein)
OPTNProtein10133 (NCBI Protein)
ORF3GeneProductORF3
P70S6KGeneProduct
PKMProtein5315 (NCBI Protein)
RAB7AProtein7879 (NCBI Protein)
RHEBProtein6009 (NCBI Protein)
RPS6Protein6194 (NCBI Protein)
RPTORProtein57521 (NCBI Protein)
SNAREsGeneProduct
SQSTM1Protein8878 (NCBI Protein)
TAX1BP1Protein8887 (NCBI Protein)
TSC2ProteinP31749 (NCBI Protein)
ULK1Protein8408 (NCBI Protein)
VPS11Protein55823 (NCBI Protein)
VPS16Protein64601 (NCBI Protein)
VPS18GeneProductVPS18
VPS33AProtein65082 (NCBI Protein)
VPS36Protein51028 (NCBI Protein)
VPS41Protein27072 (NCBI Protein)
mTORC1GeneProduct

Annotated Interactions

No annotated interactions

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