Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)

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cargo sequestrationLegendPhagophoreHOPS COMPLEXAutophagosome/Autophagy receptors Accumulation of autophagy receptors Phospho(S/T) siteVPS36CALCOCO2HOPS COMPLEXATG16LGSK3ORF3VPS11VPS41MAP1LC3BOPTNAKTS1ULK1ATG5RPTORVPS33AATG3VPS16MTORPKMRPS6mTORC1ATG7P70S6KRAB7ASQSTM1DEPTORMLST8AMPKATG4VPS18AKT1TSC2FIP200LARP1TAX1BP1SNAREsATG12ORF3ATG13ATG9ANRB1GABARAPL2RHEB S366S18T525S479K149K143S638K74K97K82T1162K435 S361S735S355S1347K46S477S766S272T269S240S238S203K157K281K24S202S738LysosomeAutophagolysosomeFusionLate endosomeUbiqutination (K) siteBindingInteractionUpregulationSARS-CoV-2 proteinInhibitionNSP61


Description

Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2, derived from the network diffusion model and overlaid with the changes in protein levels, ubiquitination and phosphorylation induced by SARS-CoV-2 infection.

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Ontology Terms

 

Bibliography

  1. Alexey Stukalov, Virginie Girault, Vincent Grass, Valter Bergant, Ozge Karayel, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, Sabri M. Hamad, Antonio Piras, Maria Tanzer, Fynn M. Hansen, Thomas Enghleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro, Matthias Mann, Andreas Pichlmair; ''Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV''; https://doi.org/10.1101/2020.06.17.156455, 2020

History

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CompareRevisionActionTimeUserComment
114087view08:27, 21 December 2020EgonwTyped 'phagophore' and give it an identifier
114075view06:17, 21 December 2020EgonwConverted a label involved in an interaction into a DataNode
112887view13:08, 15 October 2020Fehrhartfixed unconnected lines
111196view04:21, 24 July 2020Rex D A BConnections
111139view16:37, 17 July 2020EgonwColored the proteins according to the COVID19 Disease Maps convention
111028view06:22, 1 July 2020EgonwUpdated the UniProt data source
110916view04:32, 21 June 2020Rex D A BOntology Term : 'altered autophagy pathway' added !
110915view04:30, 21 June 2020Rex D A BOntology Term : 'infectious disease pathway' added !
110914view04:18, 21 June 2020Rex D A BModified description
110913view04:17, 21 June 2020Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
GeneProduct
AKT1ProteinP31749 (Uniprot-TrEMBL)
AKTS1GeneProduct
AMPKProtein5563 (NCBI Protein)
ATG12Protein9140 (NCBI Protein)
ATG13Protein9776 (NCBI Protein)
ATG16LProtein55054 (NCBI Protein)
ATG3Protein64422 (NCBI Protein)
ATG4GeneProduct
ATG5Protein9474 (NCBI Protein)
ATG7Protein10533 (NCBI Protein)
ATG9AProtein79065 (NCBI Protein)
CALCOCO2Protein10241 (NCBI Protein)
DEPTORProtein64798 (NCBI Protein)
FIP200Protein9821 (NCBI Protein)
GABARAPL2Protein11345 (NCBI Protein)
GSK3ProteinP31749 (NCBI Protein)
HOPS COMPLEXGeneProductHOPS COMPLEX
LARP1GeneProductLARP1
MAP1LC3BGeneProduct81631 (NCBI Protein)
MLST8Protein64223 (NCBI Protein)
MTORProtein2475 (NCBI Protein)
NRB1GeneProduct
NSP6ProteinYP_009725302 (NCBI Protein)
OPTNProtein10133 (NCBI Protein)
ORF3GeneProductORF3
P70S6KGeneProduct
PKMProtein5315 (NCBI Protein)
PhagophoreCellularComponentQ34360359 (Wikidata)
RAB7AProtein7879 (NCBI Protein)
RHEBProtein6009 (NCBI Protein)
RPS6Protein6194 (NCBI Protein)
RPTORProtein57521 (NCBI Protein)
SNAREsGeneProduct
SQSTM1Protein8878 (NCBI Protein)
TAX1BP1Protein8887 (NCBI Protein)
TSC2ProteinP31749 (NCBI Protein)
ULK1Protein8408 (NCBI Protein)
VPS11Protein55823 (NCBI Protein)
VPS16Protein64601 (NCBI Protein)
VPS18GeneProductVPS18
VPS33AProtein65082 (NCBI Protein)
VPS36Protein51028 (NCBI Protein)
VPS41Protein27072 (NCBI Protein)
mTORC1GeneProduct

Annotated Interactions

No annotated interactions

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