Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 (Homo sapiens)

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Autophagosome/Phospho(S/T) siteLegendcargo sequestrationAccumulation of autophagy receptors Autophagy receptors PhagophoreHOPS COMPLEXVPS36HOPS COMPLEXATG16LGSK3ORF3VPS11ATG3ORF3MLST8MAP1LC3BAKTS1VPS18ULK1MTORRPTORATG5VPS33AVPS16P70S6KATG7TSC2AKT1NSP6OPTNATG4ATG12mTORC1VPS41TSC2SQSTM1DEPTORTAX1BP1SNAREsGABARAPL2CALCOCO2LARP1ORF3RPS6RAB7AAMPKNRB1PKMATG9AFIP200RHEBATG13S203K24 S366S272S479S738S238S735K143S18S766S355K435 S361K157T269K149T525K74S638S477K82K46S1347K281T1162S202K971S240LysosomeAutophagolysosomeFusionLate endosomeUbiqutination (K) siteBindingInteractionUpregulationSARS-CoV-2 proteinInhibition


Description

Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2, derived from the network diffusion model and overlaid with the changes in protein levels, ubiquitination and phosphorylation induced by SARS-CoV-2 infection.

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Bibliography

  1. Alexey Stukalov1
    • , Virginie Girault1
    • , Vincent Grass1
    • , Valter Bergant1
    • , Ozge Karayel2
    • , Christian
    Urban1
    • , Darya A. Haas1
    • , Yiqi Huang1
    , Lila Oubraham1 , Anqi Wang1 , Sabri M. Hamad1 , Antonio Piras1 , Maria Tanzer2 , Fynn M. Hansen2 , Thomas Enghleitner3 , Maria Reinecke4, 5, Teresa M. Lavacca1 , Rosina Ehmann6, 7, Roman Wölfel6, 7, Jörg Jores8 , Bernhard Kuster4, 5, Ulrike Protzer1, 7, Roland Rad3 , John Ziebuhr9 , Volker Thiel10, Pietro Scaturro1,11, Matthias Mann2 and Andreas Pichlmair1, 7, §; ''Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV''; https://doi.org/10.1101/2020.06.17.156455, 2020

History

CompareRevisionActionTimeUserComment
110912view16:09, 20 June 2020Rex D A BModified description
110911view16:04, 20 June 2020Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
GeneProduct
AKT1ProteinP31749 (Uniprot-SwissProt)
AKTS1GeneProductAKTS1
AMPKGeneProductAMPK
ATG12GeneProductATG12
ATG13GeneProductATG13
ATG16LGeneProductATG16L
ATG3GeneProductATG3
ATG4GeneProductATG4
ATG5GeneProductATG5
ATG7GeneProductATG7
ATG9AGeneProductATG9A
CALCOCO2GeneProductCALCOCO2
DEPTORGeneProductDEPTOR
FIP200GeneProductFIP200
GABARAPL2GeneProductGABARAPL2
GSK3ProteinP31749 (NCBI Protein)
HOPS COMPLEXGeneProductHOPS COMPLEX
LARP1GeneProductLARP1
MAP1LC3BGeneProductMAP1LC3B
MLST8GeneProductMLST8
MTORGeneProductMTOR
NRB1GeneProductNRB1
NSP6GeneProductP0DTD1 / PRO_0000449624 (UniGene)
OPTNGeneProductOPTN
ORF3GeneProductORF3
P70S6KGeneProductP70S6K
PKMGeneProductPKM
RAB7AGeneProductRAB7A
RHEBGeneProductRHEB
RPS6GeneProductRPS6
RPTORGeneProductRPTOR
SNAREsGeneProductSNAREs
SQSTM1GeneProductSQSTM1
TAX1BP1GeneProductTAX1BP1
TSC2ProteinP31749 (NCBI Protein)
TSC2GeneProductTSC2
ULK1GeneProductULK1
VPS11GeneProductVPS11
VPS16GeneProductVPS16
VPS18GeneProductVPS18
VPS33AGeneProductVPS33A
VPS36GeneProductVPS36
VPS41GeneProductVPS41
mTORC1GeneProductmTORC1

Annotated Interactions

No annotated interactions

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