Direct Reversal Repair (Homo sapiens)

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Damaged base with CH2OH groupALKBH3ALKBH2MGMT5'5'3'3'5'5'3'3'5'5'3'3'Native DNADamaged base with CH3 group


Description

Direct reversal repair is a mechanism of repair where the damaged area or lesion is repaired directly by specialized proteins. It does not involve breakage of the phosphodiester backbone and doesn't require a reference template unlike the other single-strand repair mechanism. Methylation of guanine bases is directly reversed by the protein methyl guanine methyl transferase (MGMT). This is an expensive process because each MGMT molecule can be used only once. Methylation of the bases cytosine and adenine is repaired by ALKBH2 and ALKBH3. This pathway is based on information from REPAIRtoire and Wikipedia.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
110595view06:09, 20 May 2020KhanspersOntology Term : 'DNA repair pathway' added !
110594view05:55, 20 May 2020KhanspersModified description
110593view05:39, 20 May 2020Khanspersdecreased board height
110592view05:39, 20 May 2020Khanspersdecreased board height
110591view05:38, 20 May 2020KhanspersNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
ALKBH2GeneProductENSG00000189046 (Ensembl)
ALKBH3GeneProductENSG00000166199 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)

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