MAPK pathway in congenital thyroid cancer (Homo sapiens)

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14, 18, 1942, 25, 3024, 28KSR124NucleusCytoplasmMAP2K23, 1912, 1914, 19, 284, 1214, 19, 289, 12, 1920, 2323, 2814, 1914, 193, 1923, 28ELK1c-FOSc-MYCc-JUNCRAFRASGTP1, 5, 7, 10-13, 15...MAP2K1SOS218MAPK31918, 20ALK tyrosine kinase receptor3, 6, 8, 17, 19GDPMAPK3SHC118, 203BRAF18, 20-22, 28...SOS1GRB2193


Description

The MAPK pathway involved in the progression of different diseases such as diabetes, developmental abnormalities and cancer since it has a essential role in the regulation a wide variety of cellular processes such as proliferation, differentiation and apoptosis. consequently, dysregulation of MAPK pathway leads to the occurrence of the related disease

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Bibliography

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History

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CompareRevisionActionTimeUserComment
111017view05:59, 30 June 2020FehrhartOntology Term : 'thyroid cancer' added !
111016view05:58, 30 June 2020FehrhartOntology Term : 'thyroid cancer pathway' added !
111015view05:58, 30 June 2020FehrhartOntology Term : 'altered Erk5 MAPK signaling pathway' added !
111014view05:57, 30 June 2020FehrhartOntology Term : 'Pathway Ontology' added !
111007view06:16, 29 June 2020FehrhartModified title
111002view17:42, 26 June 2020Omranhasanrename Nucleus
110897view11:21, 18 June 2020OmranhasanModified description
110880view11:38, 17 June 2020OmranhasanAdd a KSR1 scaffolding protein with references
110838view09:15, 12 June 2020Omranhasanvisualization
110833view22:19, 11 June 2020Omranhasanadding annotation to the pathway components add visualization
110826view11:19, 10 June 2020Omranhasan_ redrawing the (GDP=>GTP) interaction _adding references to the interactions
110778view11:18, 4 June 2020Omranhasanconnecting nodes
110777view09:23, 4 June 2020Omranhasanconnecting tyrosine kinase receptor to the the adopter proteins ( GRB2,SHC1)
110771view20:56, 3 June 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110769view13:16, 3 June 2020Omranhasantest
110680view11:18, 28 May 2020Fehrharttest2
110679view11:15, 28 May 2020Fehrharttest
110678view11:14, 28 May 2020Fehrhartconnected a line for test
110520view06:48, 17 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110505view11:53, 15 May 2020OmranhasanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment

RAS

ProteinENSG00000133703 (Ensembl) RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras> also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)
ALK tyrosine kinase receptorProteinQ9UM73 (Uniprot-TrEMBL)
BRAFGeneProductENSG00000157764 (Ensembl)
CRAF GeneProductENSG00000132155 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2ProteinQ75VX8 (Uniprot-TrEMBL)
GTPMetaboliteCHEBI:15996 (ChEBI)
KSR1GeneProductENSG00000141068 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK3 GeneProductENSG00000102882 (Ensembl) Also known as ERK
MAPK3GeneProductENSG00000102882 (Ensembl)
  • Also known as ERK
  • Type your comment here
SHC1GeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
c-FOSGeneProductENSG00000170345 (Ensembl)
c-JUNGeneProductENSG00000177606 (Ensembl)
c-MYCGeneProductENSG00000136997 (Ensembl)

Annotated Interactions

No annotated interactions

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