Mitochondrial CII Assembly (Homo sapiens)

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1IMComplex IIMatrixSDHCSDHDFADSDHBSDHAF4SDHAF2SDHAF1SDHASDHAF3IMSSDHASDHAF2SDHAF4SDHAF1SDHASDHBSDHAF3SDHAF1SDHBSDHAF1SDHAF3SDHAF4SDHDSDHBSDHCSDHA


Description

Complex II or succinate dehydrogenase (quinone) is shared between the TCA cycle and the ETC. It has no proton pumping activity. It is composed of four subunits encoded by nDNA. Two subunits are hydrophillic, SDHA and SDHB, and two subunits are hydrophobic: SDHC and SDHD. Complex II assembly occurs through the independent maturation of these subunits mediated by subunit-specific chaperones.

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Ontology Terms

 

Bibliography

  1. Signes A, Fernandez-Vizarra E; ''Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.''; Essays Biochem, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110413view10:18, 9 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110387view16:03, 8 May 2020AnnabayaModified description
110376view15:24, 8 May 2020AnnabayaOntology Term : 'electron transport chain pathway' added !
110375view15:24, 8 May 2020AnnabayaOntology Term : 'oxidative phosphorylation pathway' added !
110354view13:39, 7 May 2020AnnabayaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
FADMetaboliteCHEBI:16238 (ChEBI)
SDHAGeneProductENSG00000073578 (Ensembl)
SDHAF1GeneProductENSG00000205138 (Ensembl)
SDHAF2GeneProductENSG00000167985 (Ensembl)
SDHAF3GeneProductENSG00000196636 (Ensembl)
SDHAF4GeneProductENSG00000154079 (Ensembl)
SDHBGeneProductENSG00000117118 (Ensembl)
SDHCGeneProductENSG00000143252 (Ensembl)
SDHDGeneProductENSG00000204370 (Ensembl)

Annotated Interactions

No annotated interactions

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