Adverse Outcome Pathway (AOP) for Mitochondrial Complex 1 (C1) inhibition (Homo sapiens)

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Cell deathLiver injuryMitochondrial dysfunctionBrain injuryKidney injuryKidneyLiverDecreased Na/K ATPase activityBrainChemical induced Fanconi syndromeDeguelinIncreased ROSAutophagyNeuroinflammationDecreased proximal tubule vectorial transportNecrosisUPRInhibition of mitochondrial Complex IDegeneration of DA neurons of nigrostratial pathwayDecreased mitochondrial oxidative phosphorylationParkinsonian motor deficitsFerroptosisRotenoneApoptosisImpaired proteostasis


Adverse Outcome Pathway (AOP) network for mitochondrial Complex 1 (C1) inhibition leading to adverse outcomes in kidney, brain and liver. Adverse Outcome Pathways (AOPs), in general, are defined as a sequence of key events that begins with a molecular initiating event (MIE) and leads to an Adverse Outcome. At that level, AOPs are described in the AOPWiki. This AOP network is based on 3 AOPs: AOPwiki:3, AOPwiki:273 and AOPwiki:276.

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111416view10:33, 7 August 2020Marvin M2Modified description
111407view16:10, 6 August 2020EveloModified description
111406view16:09, 6 August 2020EveloModified description
111405view16:05, 6 August 2020EveloModified description
111404view16:04, 6 August 2020EveloModified description
111403view15:51, 6 August 2020EveloOntology Term : 'Parkinson's disease' added !
111402view15:43, 6 August 2020EveloModified description
111401view15:43, 6 August 2020EveloOntology Term : 'Fanconi-like syndrome' added !
111400view15:42, 6 August 2020EveloOntology Term : 'altered energy metabolic pathway' added !
111399view15:39, 6 August 2020EveloModified title
110993view17:50, 25 June 2020Marvin M2Modified title
110831view12:58, 11 June 2020AnnabayaEdit pathway node shapes
110381view15:34, 8 May 2020AnnabayaOntology Term : 'immune response pathway' added !
110378view15:29, 8 May 2020AnnabayaAdd pathway identifiers
110314view22:12, 3 May 2020Marvin M2Connected unconnected lines
110303view06:37, 3 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110271view13:53, 1 May 2020AnnabayaModified title
110270view13:51, 1 May 2020AnnabayaNew pathway

External references


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NameTypeDatabase referenceComment
ApoptosisPathwayWP1772 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
Decreased mitochondrial oxidative phosphorylationPathwayWP111 (WikiPathways)
Decreased proximal tubule vectorial transportPathwayWP4917 (WikiPathways)
Degeneration of DA neurons of nigrostratial pathwayPathwayWP2855 (WikiPathways)
DeguelinMetaboliteCHEBI:4357 (ChEBI)
FerroptosisPathwayWP4313 (WikiPathways)
Impaired proteostasisPathwayWP4918 (WikiPathways)
Increased ROSPathwayWP3941 (WikiPathways)
Inhibition of mitochondrial Complex IPathwayWP4324 (WikiPathways)
NecrosisPathwayWP3383 (WikiPathways)
NeuroinflammationPathwayWP4919 (WikiPathways)
Parkinsonian motor deficitsPathwayWP2371 (WikiPathways)
RotenoneMetaboliteCHEBI:28201 (ChEBI)
UPRPathwayWP4925 (WikiPathways)

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