3q29 copy number variation syndrome (Homo sapiens)

From WikiPathways

Jump to: navigation, search
1044272915, 246, 251130, 3726417314219312, 401672443817144828, 332412113, 1811459, 321234, 4310242382, 4034, 43, 4846little information available:upregulated in regulatory macrophages during Leishmania infectionGlycosylphosphatidylinositol-mannosyltransferase 1phosphorylated stateChromosome 3:195,788,299Iron uptakeControls phosphatidylcholine synthesistranscriptionalsilencingspecific and selectivestimulation of TGFb1 inmicrogliaBile acid transportand uptakaunknown functionRNA genecentriole organizationProposed model of IFT dynein compositionRegulation of Iron uptakephosphorylationtargetsPalmitoylation47Choline phosphate(1−)HAMPATM signaling networkS-palmitoyl-L-cysteine residueof a proteinZNF76Nuclear cap-binding complexNCBP2AS2Taurocholic acidSLC40A1SMCO1RN7SL738PFe2+TCTEX1D2SENP5GRIA1TNK2-AS1UBXN7MAD2L1BPRNU6-646PSTAT5BMYCBP2TFNF2UBE2NJUNRNU6-910PPIGZDiphosphate(3−)NCBP2WDR53TM4SF19RNU6-42PL-serine residueCASP7RNU7-18PSLC51AZDHHC19Prostaglandin E2palmitoyl-CoA(4−)CoASIRT1LINC00885RPS29P3BRINP1TM4SF19-TCTEX1D2 O-phospho-L-serine(2−) residueRN7SL434PFe2+CEP19CTP4−STAT5AFBXW7MELTFhsa-mir-4797NRROSDLG1MYCRNF168L-cysteine residueof a proteinuH2BRNU4-89PDYNC2H1PIGXUBXN7-AS1TGFB1FNDC8HIF1ADYNC2LI1RNU2-11PPCYT1AMCRS1PIK3R3NCBP2-AS1Post-translational modification: synthesis of GPI-anchored proteinsMELTF-AS1RABL2BHFEPXNTFRCFGFR1OPADAM10DLG1-AS1PIGMTM4SF19-AS1LINC01063NCBP1RPSAP69PAK2FBXO45DigoxinCEP350RNF8Estrone sulfateWDR60FRAX1036SDHAP1RNU6-1279PSLC51BGenes related to primarycilium developmentCDP-choline(1−)Chromosome 3:197,033,296pseudo gene2414SLC51A121212292929WDR34TCTEX1D2DYNLT1TCTEX1D2DYNLT3DYNLRB1DYNLRB2DYNLL1DYNLL2DYNC2LI1DYNC2H1AKT1HIF1AUUubiquitinated stateRNF168FBXO45PIGXSTAT5AMYCSTAT5BPXNJUNNF2CASP7BRINP1SBRINP1SSUMOylated stateNCBP2


Description

3q29 copy number variation (duplication or deletion) is a rare genetic condition that results in a variety of psychiatric problems. The genes on the red DNA strand represents the deleted, or duplicated, region. The downstream effects and interaction partners of the different genes are shown according to available knowledge. The breakpoints (chr3:195,788,299 – 197,033,296, GRCh37/hg19) are defined as given in Cox and Butler PMID: 25714563.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Nemeth E, Ganz T; ''Regulation of iron metabolism by hepcidin.''; Annu Rev Nutr, 2006 PubMed Europe PMC Scholia
  2. Coffer PJ, Woodgett JR; ''Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.''; Eur J Biochem, 1991 PubMed Europe PMC Scholia
  3. Mahajan K, Coppola D, Rawal B, Chen YA, Lawrence HR, Engelman RW, Lawrence NJ, Mahajan NP; ''Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.''; J Biol Chem, 2012 PubMed Europe PMC Scholia
  4. Lee JH, Wittki S, Bräu T, Dreyer FS, Krätzel K, Dindorf J, Johnston IC, Gross S, Kremmer E, Zeidler R, Schlötzer-Schrehardt U, Lichtenheld M, Saksela K, Harrer T, Schuler G, Federico M, Baur AS; ''HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases.''; Mol Cell, 2013 PubMed Europe PMC Scholia
  5. Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP; ''Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.''; PLoS One, 2010 PubMed Europe PMC Scholia
  6. Ong CC, Gierke S, Pitt C, Sagolla M, Cheng CK, Zhou W, Jubb AM, Strickland L, Schmidt M, Duron SG, Campbell DA, Zheng W, Dehdashti S, Shen M, Yang N, Behnke ML, Huang W, McKew JC, Chernoff J, Forrest WF, Haverty PM, Chin SF, Rakha EA, Green AR, Ellis IO, Caldas C, O'Brien T, Friedman LS, Koeppen H, Rudolph J, Hoeflich KP; ''Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.''; Breast Cancer Res, 2015 PubMed Europe PMC Scholia
  7. Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Coté AG, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF, Kishore N, Knapp JJ, Kovács IA, Lemmens I, Mee MW, Mellor JC, Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG, Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman GM, Simonovsky E, Taşan M, Tejeda A, Tropepe V, Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP, Calderwood MA; ''A reference map of the human binary protein interactome.''; Nature, 2020 PubMed Europe PMC Scholia
  8. Park JH, Lee SW, Yang SW, Yoo HM, Park JM, Seong MW, Ka SH, Oh KH, Jeon YJ, Chung CH; ''Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.''; Nat Commun, 2014 PubMed Europe PMC Scholia
  9. Huang Z, Traugh JA, Bishop JM; ''Negative control of the Myc protein by the stress-responsive kinase Pak2.''; Mol Cell Biol, 2004 PubMed Europe PMC Scholia
  10. Berger A, Hoelbl-Kovacic A, Bourgeais J, Hoefling L, Warsch W, Grundschober E, Uras IZ, Menzl I, Putz EM, Hoermann G, Schuster C, Fajmann S, Leitner E, Kubicek S, Moriggl R, Gouilleux F, Sexl V; ''PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis.''; Leukemia, 2014 PubMed Europe PMC Scholia
  11. Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, Scambler PJ, Ueffing M, Kayserili H, Krakow D, King SM, Beales PL, Al-Gazali L, Wicking C, Cormier-Daire V, Roepman R, Mitchison HM, Witman GB; ''TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport.''; Nat Commun, 2015 PubMed Europe PMC Scholia
  12. Veitch DP, Gilham D, Cornell RB; ''The role of histidine residues in the HXGH site of CTP:phosphocholine cytidylyltransferase in CTP binding and catalysis.''; Eur J Biochem, 1998 PubMed Europe PMC Scholia
  13. Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N; ''The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  14. Baumgart F, Corral-Escariz M, Pérez-Gil J, Rodríguez-Crespo I; ''Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  15. Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC; ''The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.''; Proc Natl Acad Sci U S A, 1998 PubMed Europe PMC Scholia
  16. Stracker TH, Roig I, Knobel PA, Marjanović M; ''The ATM signaling network in development and disease.''; Front Genet, 2013 PubMed Europe PMC Scholia
  17. Richter KT, Kschonsak YT, Vodicska B, Hoffmann I; ''FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.''; Cell Death Differ, 2020 PubMed Europe PMC Scholia
  18. Seward DJ, Koh AS, Boyer JL, Ballatori N; ''Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  19. Kennard ML, Richardson DR, Gabathuler R, Ponka P, Jefferies WA; ''A novel iron uptake mechanism mediated by GPI-anchored human p97.''; EMBO J, 1995 PubMed Europe PMC Scholia
  20. Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T; ''Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner.''; Biochem Biophys Res Commun, 2001 PubMed Europe PMC Scholia
  21. Dawson PA, Hubbert ML, Rao A; ''Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  22. Mahajan NP, Whang YE, Mohler JL, Earp HS; ''Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.''; Cancer Res, 2005 PubMed Europe PMC Scholia
  23. Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW; ''SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  24. West AP Jr, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ; ''Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE.''; J Biol Chem, 2000 PubMed Europe PMC Scholia
  25. Licciulli S, Maksimoska J, Zhou C, Troutman S, Kota S, Liu Q, Duron S, Campbell D, Chernoff J, Field J, Marmorstein R, Kissil JL; ''FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.''; J Biol Chem, 2013 PubMed Europe PMC Scholia
  26. Li T, Zhang J, Zhu F, Wen W, Zykova T, Li X, Liu K, Peng C, Ma W, Shi G, Dong Z, Bode AM; ''P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.''; Carcinogenesis, 2011 PubMed Europe PMC Scholia
  27. Rong R, Surace EI, Haipek CA, Gutmann DH, Ye K; ''Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression.''; Oncogene, 2004 PubMed Europe PMC Scholia
  28. Kim JE, Chen J, Lou Z; ''DBC1 is a negative regulator of SIRT1.''; Nature, 2008 PubMed Europe PMC Scholia
  29. Helmink BA, Braker JD, Kent C, Friesen JA; ''Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha.''; Biochemistry, 2003 PubMed Europe PMC Scholia
  30. Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ; ''UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.''; Cell, 2008 PubMed Europe PMC Scholia
  31. Ashida H, Hong Y, Murakami Y, Shishioh N, Sugimoto N, Kim YU, Maeda Y, Kinoshita T; ''Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.''; Mol Biol Cell, 2005 PubMed Europe PMC Scholia
  32. Zeng Y, Broxmeyer HE, Staser K, Chitteti BR, Park SJ, Hahn S, Cooper S, Sun Z, Jiang L, Yang X, Yuan J, Kosoff R, Sandusky G, Srour EF, Chernoff J, Clapp DW; ''Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.''; Stem Cells, 2015 PubMed Europe PMC Scholia
  33. Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W; ''Negative regulation of the deacetylase SIRT1 by DBC1.''; Nature, 2008 PubMed Europe PMC Scholia
  34. Nishijima Y, Hagiya Y, Kubo T, Takei R, Katoh Y, Nakayama K; ''RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.''; Mol Biol Cell, 2017 PubMed Europe PMC Scholia
  35. Linseman DA, Heidenreich KA, Fisher SK; ''Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  36. Carraway KL, Perez A, Idris N, Jepson S, Arango M, Komatsu M, Haq B, Price-Schiavi SA, Zhang J, Carraway CA; ''Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive.''; Prog Nucleic Acid Res Mol Biol, 2002 PubMed Europe PMC Scholia
  37. Bandau S, Knebel A, Gage ZO, Wood NT, Alexandru G; ''UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.''; BMC Biol, 2012 PubMed Europe PMC Scholia
  38. Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D; ''The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.''; Cell, 2009 PubMed Europe PMC Scholia
  39. Mahajan NP, Liu Y, Majumder S, Warren MR, Parker CE, Mohler JL, Earp HS, Whang YE; ''Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  40. Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA; ''Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.''; Proc Natl Acad Sci U S A, 1991 PubMed Europe PMC Scholia
  41. Satoh T, Kato J, Nishida K, Kaziro Y; ''Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation.''; FEBS Lett, 1996 PubMed Europe PMC Scholia
  42. Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S; ''Crystal structure of the human nuclear cap binding complex.''; Mol Cell, 2001 PubMed Europe PMC Scholia
  43. Kanie T, Abbott KL, Mooney NA, Plowey ED, Demeter J, Jackson PK; ''The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.''; Dev Cell, 2017 PubMed Europe PMC Scholia
  44. Qin Y, Garrison BS, Ma W, Wang R, Jiang A, Li J, Mistry M, Bronson RT, Santoro D, Franco C, Robinton DA, Stevens B, Rossi DJ, Lu C, Springer TA; ''A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.''; Cell, 2018 PubMed Europe PMC Scholia
  45. Li X, Wen W, Liu K, Zhu F, Malakhova M, Peng C, Li T, Kim HG, Ma W, Cho YY, Bode AM, Dong Z; ''Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  46. Taron BW, Colussi PA, Wiedman JM, Orlean P, Taron CH; ''Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivo.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  47. Christensen SM, Belew AT, El-Sayed NM, Tafuri WL, Silveira FT, Mosser DM; ''Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis.''; PLoS Negl Trop Dis, 2019 PubMed Europe PMC Scholia
  48. Mojarad BA, Gupta GD, Hasegan M, Goudiam O, Basto R, Gingras AC, Pelletier L; ''CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme.''; Open Biol, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115773view13:39, 11 March 2021Fehrhartupdate to GRCh37
115768view12:42, 11 March 2021FehrhartModified description
115767view12:40, 11 March 2021Fehrhartupdated breakpoints
110951view16:49, 23 June 2020EgonwReplaced a secondary ChEBI identifier
110939view09:29, 23 June 2020Fehrhartwork in progress
110938view08:44, 23 June 2020Fehrhartwork in progress SENP5
110937view08:13, 23 June 2020Fehrhartwork in progress - PAK2
110927view13:42, 22 June 2020Fehrhartwork in progress - PIGX, CEP19
110907view13:40, 19 June 2020Fehrhartwork in progress NRROS
110899view12:04, 18 June 2020Fehrhartwork in progress - FBXO45
110898view11:50, 18 June 2020Fehrhartwork in progress RNF168 and SMCO1
110896view11:04, 18 June 2020Fehrhartwork in progress
110586view11:15, 19 May 2020Fehrhartwork in progress
110580view10:46, 19 May 2020Fehrhartwork in progress
110578view10:18, 19 May 2020Fehrhartwork in progress
110317view22:18, 3 May 2020Marvin M2Ontology Term : 'chromosomal disease' added !
110316view22:17, 3 May 2020Marvin M2Ontology Term : 'chromosome 3q29 microduplication syndrome' added !
110315view22:17, 3 May 2020Marvin M2Ontology Term : 'chromosome 3q29 microdeletion syndrome' added !
110304view06:42, 3 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110269view12:44, 1 May 2020Fehrhartadded reference
110268view12:26, 1 May 2020Fehrhartwork in progress
110251view10:40, 30 April 2020Fehrhartwork in progress
110250view10:28, 30 April 2020Fehrhartwork in progress (TFRC)
110176view09:19, 23 April 2020Fehrhartwork in progress
110161view08:54, 22 April 2020FehrhartOntology Term : 'disease of mental health' added !
110160view08:54, 22 April 2020FehrhartOntology Term : 'disease pathway' added !
110159view08:53, 22 April 2020FehrhartModified description
110158view08:49, 22 April 2020FehrhartWork in progress
110147view06:47, 21 April 2020FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
O-phospho-L-serine(2−) residueMetabolite83421 (ChEBI)
ADAM10GeneProductENSG00000137845 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
ATM signaling networkPathwayWP3878 (WikiPathways)
BRINP1GeneProductENSG00000078725 (Ensembl) DBC1
CASP7GeneProductENSG00000165806 (Ensembl)
CDP-choline(1−)Metabolite58779 (ChEBI)
CEP19GeneProductENSG00000174007 (Ensembl)
CEP350GeneProductENSG00000135837 (Ensembl)
CTP4−Metabolite37563 (ChEBI)
Choline phosphate(1−)Metabolite295975 (ChEBI)
CoAMetabolite57287 (ChEBI)
DLG1-AS1RnaENSG00000227375 (Ensembl) ncRNA
DLG1GeneProductENSG00000075711 (Ensembl)
DYNC2H1GeneProductENSG00000187240 (Ensembl)
DYNC2LI1GeneProductENSG00000138036 (Ensembl)
DYNLL1GeneProductENSG00000088986 (Ensembl)
DYNLL2GeneProductENSG00000264364 (Ensembl)
DYNLRB1GeneProductENSG00000125971 (Ensembl)
DYNLRB2GeneProductENSG00000168589 (Ensembl)
DYNLT1GeneProductENSG00000146425 (Ensembl)
DYNLT3GeneProductENSG00000165169 (Ensembl)
DigoxinMetabolite2724385 (PubChem-compound)
Diphosphate(3−)Metabolite33019 (ChEBI)
Estrone sulfateMetabolite3001028 (PubChem-compound)
FBXO45GeneProductENSG00000174013 (Ensembl)
FBXW7GeneProductENSG00000109670 (Ensembl)
FGFR1OPGeneProductENSG00000213066 (Ensembl)
FNDC8GeneProductENSG00000073598 (Ensembl)
FRAX1036Metabolite71557891 (PubChem-compound)
Fe2+MetaboliteCHEBI:29033 (ChEBI)
GRIA1GeneProductENSG00000155511 (Ensembl) GluR1
Genes related to primary cilium developmentPathwayWP4536 (WikiPathways)
HAMPGeneProductENSG00000105697 (Ensembl)
HFEGeneProductENSG00000010704 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
L-cysteine residue of a proteinMetabolite29950 (ChEBI)
L-serine residueMetaboliteCHEBI:29999 (ChEBI)
LINC00885RnaENSG00000224652 (Ensembl) ncRNA
LINC01063RnaENSG00000232065 (Ensembl) ncRNA
MAD2L1BPGeneProductENSG00000124688 (Ensembl)
MCRS1GeneProductENSG00000187778 (Ensembl)
MELTF-AS1RnaENSG00000228109 (Ensembl) ncRNA
MELTFGeneProductENSG00000163975 (Ensembl)
MYCBP2GeneProductENSG00000005810 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NCBP1GeneProductENSG00000136937 (Ensembl)
NCBP2-AS1RnaENSG00000225578 (Ensembl) ncRNA
NCBP2AS2RnaENSG00000270170 (Ensembl) ncRNA
NCBP2GeneProductENSG00000114503 (Ensembl)
NF2GeneProductENSG00000186575 (Ensembl) merlin
NRROSGeneProductENSG00000174004 (Ensembl) LRRC33
Nuclear cap- binding complexComplexCPX-1427 (EMBL) Complex Database (EMBL)
PAK2GeneProductENSG00000180370 (Ensembl)
PCYT1AGeneProductENSG00000161217 (Ensembl)
PIGMGeneProductENSG00000143315 (Ensembl)
PIGXGeneProductENSG00000163964 (Ensembl)
PIGZGeneProductENSG00000119227 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PXNGeneProductENSG00000089159 (Ensembl)
Post-translational modification: synthesis of GPI-anchored proteinsPathwayWP1887 (WikiPathways)
Prostaglandin E2Metabolite5280360 (PubChem-compound)
RABL2BGeneProductENSG00000079974 (Ensembl)
RN7SL434PGeneProductENSG00000241868 (Ensembl) pseudo
RN7SL738PGeneProductENSG00000243339 (Ensembl) pseudo
RNF168GeneProductENSG00000163961 (Ensembl)
RNF8GeneProductENSG00000112130 (Ensembl)
RNU2-11PGeneProductENSG00000239122 (Ensembl) pseudo gene
RNU4-89PGeneProductENSG00000272359 (Ensembl) pseudo gene
RNU6-1279PGeneProductENSG00000206644 (Ensembl) pseudo gene
RNU6-42PGeneProductENSG00000206892 (Ensembl) pseudo gene
RNU6-646PGeneProductENSG00000201441 (Ensembl) pseudo gene
RNU6-910PGeneProductENSG00000212146 (Ensembl) pseudo gene
RNU7-18PGeneProductENSG00000252174 (Ensembl) pseudo gene
RPS29P3GeneProductENSG00000225770 (Ensembl) pseudo gene
RPSAP69GeneProductENSG00000233487 (Ensembl) pseudo gene
S-palmitoyl-L-cysteine residue of a proteinMetabolite74151 (ChEBI)
SDHAP1GeneProductENSG00000185485 (Ensembl) pseudo gene
SENP5GeneProductENSG00000119231 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SLC40A1GeneProductENSG00000138449 (Ensembl) Ferroportin
SLC51AGeneProductENSG00000163959 (Ensembl) OSTA, OSTalpha
SLC51BGeneProductENSG00000186198 (Ensembl) OSTB, OSTbeta
SMCO1GeneProductENSG00000214097 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
TCTEX1D2GeneProductENSG00000213123 (Ensembl)
TFGeneProductENSG00000091513 (Ensembl) Transferrin
TFRCGeneProductENSG00000072274 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TM4SF19-AS1RnaENSG00000235897 (Ensembl) ncRNA
TM4SF19-TCTEX1D2RnaENSG00000273331 (Ensembl) ncRNA
TM4SF19GeneProductENSG00000145107 (Ensembl)
TNK2-AS1RnaENSG00000224614 (Ensembl) ncRNA
Taurocholic acidMetabolite6675 (PubChem-compound)
UBE2NGeneProductENSG00000177889 (Ensembl)
UBXN7-AS1RnaENSG00000225822 (Ensembl) ncRNA
UBXN7GeneProductENSG00000163960 (Ensembl)
WDR34GeneProductENSG00000119333 (Ensembl)
WDR53GeneProductENSG00000185798 (Ensembl)
WDR60GeneProductENSG00000126870 (Ensembl)
ZDHHC19GeneProductENSG00000163958 (Ensembl) Palmitoyltransferase
ZNF76GeneProductENSG00000065029 (Ensembl)
hsa-mir-4797RnaENSG00000265850 (Ensembl)
palmitoyl-CoA(4−)Metabolite57379 (ChEBI)
uH2BGeneProductubiquitinated histone H2B - histone H2B is a gene family of about 23 genes

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
CTP4−CDP-choline(1−)mim-conversion18997 (Rhea)
CTP4−Diphosphate(3−)mim-conversion18997 (Rhea)
Choline phosphate(1−)CDP-choline(1−)mim-conversion18997 (Rhea)
Choline phosphate(1−)Diphosphate(3−)mim-conversion18997 (Rhea)
FNDC8MAD2L1BPmim-bindingEBI-25261866 (IntAct)
FNDC8MCRS1mim-bindingEBI-23791541 (IntAct)
FNDC8PIK3R3mim-bindingEBI-24039109 (IntAct)
FNDC8ZNF76mim-bindingEBI-23501218 (IntAct)
L-serine residue O-phospho-L-serine(2−) residuemim-conversion17989 (Rhea)
SMCO1FNDC8mim-bindingEBI-23405860 (IntAct)
ZDHHC19mim-catalysis36683 (Rhea)
Personal tools