IL-2 signaling pathway (Homo sapiens)

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STAT5BSTAT3STAT1MAPK1PSTAT1AKT1P1CYNURas-MAPK cascadeNUNUCYCYNUmediated gene expressionAKT dependentIL-2 signaling pathwaygene expressionCYCBLGAB2PMAP2K2PSHC1PFYNPIL2CRKLLCKSTAT5BPIL2RGPRPS6MYCCCND2IL2RAJUNBCL2FOSIL2RASTAT1PMTORSOS1RAF1PMAP2K1PIL2RBPSTAT3PSTAT1PCISHFOXO3ASTAT1PGRB2JAK3PMAPK3PSTAT3PTK2BPPTPN11PRPS6KB1RPS6KB2PPJAK1PSTAT5APSYKPSTAT5ANMISTAT5APSOCS3PIK3R1PSTAT3STAT3PProteinProtein - protein dissociationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageReceptorProteinmRNALigandEnzyme complexHRAS


IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, please cite the NetPath website until the pathway is published.

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  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia


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120703view13:20, 23 December 2021EweitzStandardize font, weight, case
116633view11:22, 9 May 2021EweitzModified title
115909view12:12, 20 March 2021EgonwCopied the NetPath paper into the literature list
115908view11:13, 20 March 2021EgonwModified description
95132view16:25, 16 November 2017Fehrhartconnecting unconnected connections
95131view16:19, 16 November 2017Fehrhartconnecting unconnected connections
91243view20:37, 21 January 2017AlexanderPicoconnected a few interactions
89826view12:04, 6 October 2016MkutmonModified description
78543view10:30, 7 January 2015MaintBotadded missing graphIds
75383view21:22, 21 May 2014KhanspersRemoved GenMAPP notes/comments
72047view16:52, 24 October 2013Mkutmonupdated annotations
70015view01:49, 12 July 2013AlexanderPicoModified title
67369view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
63209view20:57, 8 May 2013MaintBotUpdating gpml version
59182view18:45, 22 February 2013MaintBotUpdated Ensembl data source
48400view07:35, 24 May 2012NetPathModified description
48399view07:30, 24 May 2012NetPathModified description
46125view21:34, 18 December 2011AlexanderPicofixed entrez references
45366view20:58, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45130view00:47, 7 October 2011AlexanderPicofixed db ref
44843view09:45, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44833view07:58, 6 October 2011Mkutmonconnected some lines
44622view17:54, 22 September 2011KhanspersUpdating content to NetSlim
44106view20:29, 24 August 2011KhanspersReverted to version '23:39, 1 March 2011' by Khanspers
44029view23:05, 22 August 2011KhanspersModified description
44028view23:03, 22 August 2011KhanspersUpdating pathway from NetSlim
41145view23:39, 1 March 2011MaintBotRemoved redundant pathway information and comments
35641view21:29, 12 February 2010KhanspersModified description
20779view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-2 NetPath 14]] moved to [[Pathway:WP49]]: Moved to stable identifier
8164view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-2 NetPath 14]] moved to [[Pathway:Homo sapiens:IL-2 NetPath 14]]: Renaming species
7702view16:10, 18 December 2007MaintBotfixed category names
7241view12:41, 4 November 2007MaintBotAdded categories to GPML
6335view22:17, 22 May 2007A.Pandeygpml file for [[Human:IL-2_NetPath_14]]

External references


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NameTypeDatabase referenceComment
AKT1Protein207 (Entrez Gene)
BCL2Rna596 (Entrez Gene)
CBLProtein867 (Entrez Gene)
CCND2Rna894 (Entrez Gene)
CISHProtein1154 (Entrez Gene)
CRKLProtein1399 (Entrez Gene)
FOSRna2353 (Entrez Gene)
FOXO3AProtein2309 (Entrez Gene)
FYNProtein2534 (Entrez Gene)
GAB2Protein9846 (Entrez Gene)
GRB2Protein2885 (Entrez Gene)
HRASGeneProductENSG00000174775 (Ensembl)
IL2Protein3558 (Entrez Gene)
IL2RAProteinENSG00000134460 (Ensembl)
IL2RBProtein3560 (Entrez Gene)
IL2RGProtein3561 (Entrez Gene)
JAK1Protein3716 (Entrez Gene)
JAK3Protein3718 (Entrez Gene)
JUNRna3725 (Entrez Gene)
LCKProtein3932 (Entrez Gene)
MAP2K1Protein5604 (Entrez Gene)
MAP2K2Protein5605 (Entrez Gene)
MAPK1Protein5594 (Entrez Gene)
MAPK3Protein5595 (Entrez Gene)
MTORProtein4137 (Entrez Gene)
MYCRna4609 (Entrez Gene)
NMIProtein9111 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PTK2BProtein2185 (Entrez Gene)
PTPN11Protein5781 (Entrez Gene)
RAF1Protein5894 (Entrez Gene)
RPS6Protein6194 (Entrez Gene)
RPS6KB1Protein6198 (Entrez Gene)
RPS6KB2Protein6199 (Entrez Gene)
SHC1Protein6464 (Entrez Gene)
SOCS3Protein9021 (Entrez Gene)
SOS1Protein6654 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein6774 (Entrez Gene)
STAT5AProtein6776 (Entrez Gene)
STAT5BProtein6777 (Entrez Gene)
SYKProtein6850 (Entrez Gene)

Annotated Interactions

No annotated interactions

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