Alpha6-Beta4 Integrin Signaling Pathway (Mus musculus)

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DemethylationDesumoylationDENActivationLaminin 10ECPalmitoylationAcetylationUbiquitinationDInhibitionProteins in a complex interactionProteolytic cleavageDNucleusPMDEREndosomeMethylationNULaminin 4SumoylationDeubiquitinationDTranslocationReaction through unknown mechanisms/moleculesPlasma membraneMolecule in the pathwayPhosphorylationLaminin 1LigandCY->NURecruitmentD(Protein-protein interaction)CY->NUDeacetylationEnzyme complexMolecular AssociationGlycosylationLaminin 5CY->PMLaminin 11DDExtracellularDMTMitochondrionCY->NUGODephosphorylationGene SymbolCytoplasmGolgi apparatusControlCYLaminin 2AutophosphorylationAccession Number: NetPath 1; cellmap:1ReceptorEndoplasmic reticulumEif4eItgb4Erbb2Irs2Lama5Erbb2ipTrp73Smad2Smad2Lamb1-1Lamb2Lama5Irs1SrcItga6Itga6Col17a1PrkcaRpsaAkt1Plec1Lamc1Itga6RtknShc1YwhahClca3RhoaLama2Pik3r1Itgb4Cdkn1aPik3r2Cd151Lamb1-1Eif6Rac1VimItgb4Pik3cbSfnArLamb2Grb2Lama1Pik3cgSmad3Lamc1Casp3Pak1Lama3Lama2Lamc2Yes1Pik3r3Eif4ebp1Pik3cdDstLamb3Smad3FynLamc1YwhabLamc1BadLamc1Eif6DspItga6Pik3caItga6Itgb4RhoaPrkcdGm2423Ptk2Abl1MetNtn1Mmp7YwhaeItga6Lamb1-1Itgb4Clca5YwhazItgb4MtorMst1rEgfr


Description

Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands of the alpha6 beta4 integrin are heterotrimers belonging to the laminin family including Laminin A2, Laminin B1, Laminin C1, Laminin A3, Laminin B3, Laminin C2, Laminin A5, Laminin A1 and Laminin B2 among others. Upon activation, the receptor is phosphorylated and associates with adaptor molecules Shc and Grb2, which then activate the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_1

Comments

GenMAPP notes 
NetPath 13: IL-1 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP244(r21193) with a 98% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
72049view16:57, 24 October 2013Mkutmonupdated annotation for Gm2423
69084view18:10, 8 July 2013MaintBotUpdated to 2013 gpml schema
67039view09:57, 26 June 2013Christine ChichesterOntology Term : 'integrin mediated signaling pathway' added !
41271view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35653view21:46, 12 February 2010KhanspersModified description
32709view22:21, 2 September 2009MaintBotfixed xrefs
32695view17:32, 1 September 2009KhanspersAdded xref
31464view21:17, 13 August 2009MaintBotFixed text labels
30827view00:00, 30 July 2009MaintBotConverted from Homo sapiens
21706view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Alpha6-Beta4-Integrin NetPath 1]] moved to [[Pathway:WP488]]: Moved to stable identifier
7898view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Alpha6-Beta4-Integrin NetPath 1]] moved to [[Pathway:Mus musculus:Alpha6-Beta4-Integrin NetPath 1]]: Renaming species
7574view16:00, 18 December 2007MaintBotfixed category names
7193view12:33, 4 November 2007MaintBotAdded categories to GPML
6413view22:18, 22 May 2007A.Pandeygpml file for [[Mouse:Alpha6-Beta4-Integrin_NetPath_1]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Abl1GeneProduct11350 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
ArGeneProduct11835 (Entrez Gene)
BadGeneProduct12015 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Cd151GeneProduct12476 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Clca3GeneProduct23844 (Entrez Gene)
Clca5GeneProduct229933 (Entrez Gene)
Col17a1GeneProduct12821 (Entrez Gene)
DspGeneProduct109620 (Entrez Gene)
DstGeneProduct13518 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Eif4eGeneProduct13684 (Entrez Gene)
Eif4ebp1GeneProduct13685 (Entrez Gene)
Eif6GeneProduct16418 (Entrez Gene)
Erbb2GeneProduct13866 (Entrez Gene)
Erbb2ipGeneProduct59079 (Entrez Gene)
FynGeneProduct14360 (Entrez Gene)
Gm2423GeneProductENSMUSG00000061724 (Ensembl)
Grb2GeneProduct14784 (Entrez Gene)
Irs1GeneProduct16367 (Entrez Gene)
Irs2GeneProduct384783 (Entrez Gene)
Itga6GeneProduct16403 (Entrez Gene)
Itgb4GeneProduct192897 (Entrez Gene)
Lama1GeneProduct16772 (Entrez Gene)
Lama2GeneProduct16773 (Entrez Gene)
Lama3GeneProduct16774 (Entrez Gene)
Lama5GeneProduct16776 (Entrez Gene)
Lamb1-1GeneProduct16777 (Entrez Gene)
Lamb2GeneProduct16779 (Entrez Gene)
Lamb3GeneProduct16780 (Entrez Gene)
Lamc1GeneProduct226519 (Entrez Gene)
Lamc2GeneProduct16782 (Entrez Gene)
MetGeneProduct17295 (Entrez Gene)
Mmp7GeneProduct17393 (Entrez Gene)
Mst1rGeneProduct19882 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
Ntn1GeneProduct18208 (Entrez Gene)
Pak1GeneProduct18479 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pik3r3GeneProduct18710 (Entrez Gene)
Plec1GeneProduct18810 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
RpsaGeneProduct16785 (Entrez Gene)
RtknGeneProduct20166 (Entrez Gene)
SfnGeneProduct55948 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Smad2GeneProduct17126 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Trp73GeneProduct22062 (Entrez Gene)
VimGeneProduct22352 (Entrez Gene)
Yes1GeneProduct22612 (Entrez Gene)
YwhabGeneProduct54401 (Entrez Gene)
YwhaeGeneProduct22627 (Entrez Gene)
YwhahGeneProduct22629 (Entrez Gene)
YwhazGeneProduct22631 (Entrez Gene)

Annotated Interactions

No annotated interactions
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