CAMKK2 Pathway (Homo sapiens)

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LabelCAMKK2 pathwayDRP1IFI44LSTIM1CALM1MAP1LC3AVCAM1MAFNFATC2HMOX1FIS1Ca2+166, 41639GATMASNSKLF1GALNT9FASNPFKFB2Theasinensins18ERMAPRPTOR40NEDD4LCaulerpin36ABCA1HK2MTORS244837CYB5R3CAMK17S100A8ACACAS7932HK2ARHGEF7S516 33EPORFOXO3AS31834S321CCNE1PFKFB2TMEM176BIsorhamnetin30Adropin4CCL5Hydrogen sulphide26TRPV4EP3003S1834 KDRSFI1WDR35Ramipril5SMC132NRF2MAP1LC3BCCND1NOS3 S117713SLCO3A1MAPK14 9Y122TSPAN33NLRP1WFS123MAP1LC3AMAPK143MX2Homocysteine sulfinic acid9FAM132aCD28KEAP1MID1Apigenin8IL15RPS6KB1HMBSEstrogen14CD28CAMK4P2RELA38VCAM1OASLCTSEMetabolitesSPINT1NOS111SREBF1CDH1GIT133SQSTM128MAP1LC3BRASGRP1Withdrawal of essential amino acids1PPAP2AEugenol15IRGCGlyceollin22RPS6PAK1 44CREB13HFEQuercetin10WFS1PCK2Hypoxia29CDC25AOxytocin12SELLTSPAN8CHRM341TREM3EIF4EBP1T46T3717S65SLC2A4ATP1B2PLAC8ICAM142GATMGDH1 31Poly unsaturated fatty acids21TNF-alphaCAMKK218, 24TBXTLaminar shear stress3AQP1ACACARAC144IRS-122, 34S636S639CXCL11GCKSPIRE1PARP1Pulsed electric field25CCR9HDCA42EPORBupivacaine38FAM20CHMOX1Betulinic acid13INN16CCND2HK1SLC2A1CAR1SLC25A21RHDMAMDC2MT1TBC1D4 T642 20ATP10DCRTC2MS4A3PFKFB3SLC38A5AHSPCPOXRHAGFatty acid biosysthesisTranslocationPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionInduced catalysisLEGENDProteinNucleusCytoplasmCYNUProtein-protein dissociationInhibitionSmall moleculePlasma membranePMNucleusSmall moleculeCREB1TSC117SIRT1 19AKTT30835S473RPS6KB1T389AutophagyAnkosis Anaerobic metabolismCytokineCellcycleHypoxiaCalcium channel transporterApoptosisGlyconeogensis Signal transductionTransportHeme biosynthesisHIF1AMembraneChemokineHK1Erythrocyte developmentPRKAA2T17218ULK1S757S555 317ApoptosisCell proliferation and migrationUbiquitinationDissociationMAPK343TSC2T1462 17PRKCAT639 27NRF2NUCYNUCYCytoplasmMetabolitesActivationmRNA


Description

CaMKK2 is a 66–68-kDa serine kinase, consists of unique N- and C-terminal domains and a central Ser/Thr-directed kinase domain that is followed by a regulatory domain composed of overlapping autoinhibitory and CaM-binding regions (PMID:9335539). CAMKK2 is activated once calmodulin (CALM1) binds with CAAMKK2. The most well characterized substrates of CaMKK2 are CaMKI, CaMKIV and AMPKα. CaMKK2 phosphorylates CaMKIV, CaMKI and AMPKα on activation loop Thr residues (Thr-200, Thr-177 and Thr-172, respectively), which increases their kinase activities (PMID:9822657). CaMKK2 is present in many areas of the brain, including the olfactory bulb, hippocampus, dentate gyrus, amygdala, hypothalamus, and cerebellum (PMID:9822657, 12654522).

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
112884view18:20, 14 October 2020EgonwReplaced gene symbols by Entrez Gene identifiers
112274view00:43, 9 October 2020Rex D A Bconnections and gene name
112262view12:10, 8 October 2020KeshavModified description
111803view15:17, 7 September 2020DeSlRemoved special characters for TNF- node (assuming this is TNF-alpha).
111802view15:15, 7 September 2020DeSladded ID for Adropin (changed from Metabolite to Protein, since it's a peptide hormone).
111801view15:11, 7 September 2020DeSladded ID for Apigenin
111800view15:10, 7 September 2020DeSladded ID for Betulinic acid
111799view15:09, 7 September 2020DeSladded ID for bupivacine (assumed this should be bupivacaine, as wikipedia suggests)
111798view15:07, 7 September 2020DeSladded ID for cauleprin (assumed this should be caulerpin, as reference suggests)
111796view14:48, 7 September 2020DeSladded ID for eugenol
111795view14:44, 7 September 2020DeSladded ID for Glyceollin
111794view14:43, 7 September 2020DeSladded ID for Homocysteine sulfinic acid
111793view14:38, 7 September 2020DeSladded ID for Isorhamnetin
111792view14:36, 7 September 2020DeSladded ID for oxytocin
111791view14:28, 7 September 2020DeSladded ID for quericin (assumed this should be quercetin, as reference suggests)
111790view14:26, 7 September 2020DeSladded ID for ramipril
111789view14:24, 7 September 2020DeSlremoved name as ID for Theasinensins
110018view19:19, 12 April 2020Keshavconnections
110016view19:13, 12 April 2020KeshavInteractions
109756view18:30, 30 March 2020KeshavOntology Term : 'cancer' added !
109755view18:29, 30 March 2020KeshavOntology Term : 'calcium/calcium-mediated signaling pathway' added !
109750view17:53, 30 March 2020KeshavTitle
109749view17:49, 30 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProductABCA1
ACACAGeneProductACACA
ACACAProteinNP_942131.1 (NCBI Protein)
AHSPGeneProductAHSP
AKTProteinNP_001014431.1 (NCBI Protein)
AQP1GeneProduct
ARHGEF7GeneProduct8874 (Entrez Gene)
ASNSGeneProductASNS
ATP10DGeneProductATP10D
ATP1B2GeneProductATP1B2
AdropinProteinIPR034461 (InterPro)
ApigeninMetaboliteCHEBI:18388 (ChEBI)
Betulinic acidMetaboliteCHEBI:3087 (ChEBI)
BupivacaineMetaboliteCHEBI:31322 (ChEBI)
CALM1GeneProduct801 (Entrez Gene)
CAMK1GeneProduct8536 (Entrez Gene)
CAMK4GeneProduct814 (Entrez Gene)
CAMKK2GeneProduct10645 (Entrez Gene)
CAR1GeneProductCAR1
CCL5GeneProductCCL5
CCND1GeneProductCCND1
CCND2GeneProductCCND2
CCNE1GeneProductCCNE1
CCR9GeneProductCCR9
CD28GeneProductCD28
CDC25AGeneProductCDC25A
CDH1GeneProductCDH1
CHRM3GeneProduct1131 (Entrez Gene)
CPOXGeneProductCPOX
CREB1GeneProduct1385 (Entrez Gene)
CRTC2GeneProductCRTC2
CTSEGeneProductCTSE
CXCL11GeneProductCXCL11
CYB5R3GeneProductCYB5R3
Ca2+
CaulerpinMetaboliteCHEBI:80923 (ChEBI)
DRP1GeneProduct10059 (Entrez Gene)
EIF4EBP1ProteinNP_004086.1 (NCBI Protein)
EP300GeneProduct2033 (Entrez Gene)
EPORGeneProductEPOR
ERMAPGeneProductERMAP
EstrogenGeneProduct
EugenolMetaboliteCHEBI:4917 (ChEBI)
FAM132aGeneProductFAM132a
FAM20CGeneProductFAM20C
FASNGeneProductFASN
FIS1GeneProduct51024 (Entrez Gene)
FOXO3AProteinNP_001446.1 (NCBI Protein)
GALNT9GeneProductGALNT9
GATMGeneProductGATM
GCKGeneProductGCK
GDH1 GeneProduct854557 (Entrez Gene)
GIT1GeneProduct28964 (Entrez Gene)
GlyceollinMetaboliteCHEBI:16470 (ChEBI)
HDCA4GeneProduct9759 (Entrez Gene)
HFEGeneProductHFE
HIF1AGeneProductHIF1A
HK1GeneProduct
HK1GeneProductHK1
HK2GeneProduct
HK2GeneProductHK2
HMBSGeneProductHMBS
HMOX1GeneProduct3162 (Entrez Gene)
Homocysteine sulfinic acidMetaboliteCHEBI:137439 (ChEBI)
Hydrogen sulphideGeneProduct
HypoxiaHypoxia
ICAM1GeneProduct3383 (Entrez Gene)
IFI44LGeneProductIFI44L
IL15GeneProductIL15
INNGeneProduct
IRGCGeneProductIRGC
IRS-1ProteinNP_005535.1 (NCBI Protein)
IsorhamnetinMetaboliteCHEBI:6052 (ChEBI)
KDRGeneProductKDR
KEAP1GeneProductKEAP1
KLF1GeneProductKLF1
Laminar shear stressLaminar shear stress (Other)
MAFGeneProduct4094 (Entrez Gene)
MAMDC2GeneProductMAMDC2
MAP1LC3AGeneProduct84557 (Entrez Gene)
MAP1LC3AGeneProductMAP1LC3A
MAP1LC3BGeneProductMAP1LC3B
MAPK14 ProteinNP_001306.1 (NCBI Protein)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3 GeneProduct5595 (Entrez Gene)
MID1GeneProductMID1
MS4A3GeneProductMS4A3
MT1GeneProductMT1
MTORGeneProduct2475 (Entrez Gene)
MX2GeneProductMX2
MetabolitesGeneProductMetabolites
NEDD4LGeneProductNEDD4L
NFATC2GeneProduct4773 (Entrez Gene)
NLRP1GeneProductNLRP1
NOS1GeneProduct4842 (Entrez Gene)
NOS3 ProteinNP_000594.2 (NCBI Protein)
NRF2GeneProduct4780 (Entrez Gene)
NRF2GeneProductNRF2
OASLGeneProductOASL
OxytocinMetaboliteCHEBI:7872 (ChEBI)
PAK1 GeneProduct5058 (NCBI Protein)
PARP1GeneProductPARP1
PCK2GeneProductPCK2
PFKFB2GeneProductPFKFB2
PFKFB3GeneProductPFKFB3
PLAC8GeneProductPLAC8
PPAP2AGeneProductPPAP2A
PRKAA2GeneProductNP_006243.2 (NCBI Protein)
PRKCAProteinNP_002728.1 (NCBI Protein)
Poly unsaturated fatty acidsGeneProduct
ProteinProtein5894 (Entrez Gene)
Pulsed electric fieldGeneProduct
QuercetinMetaboliteCHEBI:16243 (ChEBI)
RAC1GeneProduct5879 (Entrez Gene)
RASGRP1GeneProductRASGRP1
RELAGeneProduct5970 (Entrez Gene)
RHAGGeneProductRHAG
RHDGeneProductRHD
RPS6KB1GeneProductRPS6KB1
RPS6GeneProductRPS6
RPTORGeneProduct57521 (Entrez Gene)
RamiprilMetaboliteCHEBI:8774 (ChEBI)
S100A8GeneProductS100A8
SELLGeneProductSELL
SFI1GeneProductSFI1
SIRT1 GeneProduct23411 (Entrez Gene)
SLC25A21GeneProductSLC25A21
SLC2A1GeneProductSLC2A1
SLC2A4GeneProductSLC2A4
SLC38A5GeneProductSLC38A5
SLCO3A1GeneProductSLCO3A1
SMC1GeneProduct8243 (Entrez Gene)
SPINT1GeneProductSPINT1
SPIRE1GeneProductSPIRE1
SQSTM1GeneProduct8878 (Entrez Gene)
SREBF1GeneProductSREBF1
STIM1GeneProduct6786 (Entrez Gene)
TBC1D4 ProteinNP_001273587.1 (NCBI Protein)
TBXTGeneProductTBXT
TMEM176BGeneProductTMEM176B
TNF-alphaGeneProduct
TREM3GeneProductTREM3
TRPV4GeneProductTRPV4
TSC1GeneProduct7248 (Entrez Gene)
TSC2ProteinNP_000539.2 (NCBI Protein)
TSPAN33GeneProductTSPAN33
TSPAN8GeneProductTSPAN8
TheasinensinsMetabolite
ULK1GeneProductULK1
VCAM1GeneProduct7412 (Entrez Gene)
WDR35GeneProductWDR35
WFS1GeneProduct7466 (Entrez Gene)
WFS1GeneProductWFS1
Withdrawal of essential amino acidsGeneProduct

Annotated Interactions

No annotated interactions

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