CAMKK2 pathway (Homo sapiens)

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CAMKK2 pathwayLabelHMOX1STIM1Ca2+IFI44LMAFFIS1MAP1LC3ACALM1NFATC2DRP1VCAM120, 44434144GATMASNSKLF1GALNT9FASNPFKFB2Theasinensins15ERMAPRPTOR3NEDD4LCaulerpin36ABCA1HK2MTORS244829CYB5R3CAMK118S100A8ACACAS7939HK2ARHGEF738S516 EPORFOXO3AS321S31840CCNE1PFKFB2TMEM176BIsorhamnetin31Adropin17CCL5Hydrogen sulphide19TRPV4EP300S1834 30KDRSFI1WDR35Ramipril14SMC139NRF2MAP1LC3BCCND1NOS3 8S1177SLCO3A1MAPK14 16Y122TSPAN33NLRP1WFS110MAP1LC3AMAPK132MX2Homocysteine sulfinic acid16FAM132aCD28KEAP1MID1Apigenin5IL15RPS6KB1HMBSEstrogen9CD28CAMK425PRELA33VCAM1OASLCTSEMetabolitesSPINT1NOS142SREBF1CDH1GIT138SQSTM135MAP1LC3BRASGRP1Withdrawal of essential amino acids13PPAP2AEugenol12IRGCGlyceollin7RPS6PAK1 24CREB130HFEQuercetin1WFS1PCK2Hypoxia28CDC25AOxytocin23SELLTSPAN8CHRM320TREM3EIF4EBP1S65T466T37SLC2A4ATP1B2PLAC8ICAM122GATMGDH1 26Poly unsaturated fatty acids21TNFCAMKK215, 34TBXTLaminar shear stress30AQP1ACACARAC124IRS-1S636S6397, 40CXCL11GCKSPIRE1PARP1Pulsed electric field2CCR9HDCA425EPORBupivacaine33FAM20CHMOX1Betulinic acid8INN41CCND2HK1SLC2A1CAR1SLC25A21RHDMAMDC2MT1TBC1D4 T642 37ATP10DCRTC2MS4A3PFKFB3SLC38A5AHSPCPOXRHAGFatty acid biosysthesisTranslocationPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionInduced catalysisLEGENDProteinNucleusCytoplasmCYNUProtein-protein dissociationInhibitionSmall moleculePlasma membranePMNucleusSmall moleculeCREB1TSC16SIRT1 27AKTS47311T308RPS6KB1T389AutophagyAnoikisAnaerobic metabolismCytokineCellcycleHypoxiaCalcium channel transporterApoptosisGlyconeogensis Signal transductionTransportHeme biosynthesisHIF1AMembraneChemokineHK1Erythrocyte developmentPRKAA2T17215ULK1S555 317S757ApoptosisCell proliferation and migrationUbiquitinationDissociationMAPK332TSC26T1462 PRKCAT639 4NRF2NUCYNUCYCytoplasmMetabolitesActivationmRNA


CaMKK2 is a 66–68-kDa serine kinase, consists of unique N- and C-terminal domains and a central Ser/Thr-directed kinase domain that is followed by a regulatory domain composed of overlapping autoinhibitory and CaM-binding regions (PMID:9335539). CAMKK2 is activated once calmodulin (CALM1) binds with CAAMKK2. The most well-characterized substrates of CaMKK2 are CaMKI, CaMKIV and AMPKα. CaMKK2 phosphorylates CaMKIV, CaMKI and AMPKα on activation loop Thr residues (Thr-200, Thr-177 and Thr-172, respectively), which increases their kinase activities (PMID:9822657). CaMKK2 is present in many areas of the brain, including the olfactory bulb, hippocampus, dentate gyrus, amygdala, hypothalamus, and cerebellum (PMID:9822657, 12654522). The creation of this pathway is described in Najar et al.

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  17. Yang F, Zhou L, Qian X, Wang D, He WJ, Tang ZW, Yin J, Huang QY; ''Adropin Is a Key Mediator of Hypoxia Induced Anti-Dipsogenic Effects via TRPV4-CamKK-AMPK Signaling in the Circumventricular Organs of Rats.''; Front Mol Neurosci, 2017 PubMed Europe PMC Scholia
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  23. Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH; ''Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.''; Regul Pept, 2008 PubMed Europe PMC Scholia
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124683view07:26, 24 November 2022Rex D A B
121708view04:43, 26 February 2022EweitzUse gene symbol
117669view11:58, 22 May 2021EweitzModified title
113833view08:50, 30 November 2020Fehrhartconnected some of the unconnected lines
113771view18:21, 19 November 2020KhanspersModified description
112884view18:20, 14 October 2020EgonwReplaced gene symbols by Entrez Gene identifiers
112274view00:43, 9 October 2020Rex D A Bconnections and gene name
112262view12:10, 8 October 2020KeshavModified description
111803view15:17, 7 September 2020DeSlRemoved special characters for TNF- node (assuming this is TNF-alpha).
111802view15:15, 7 September 2020DeSladded ID for Adropin (changed from Metabolite to Protein, since it's a peptide hormone).
111801view15:11, 7 September 2020DeSladded ID for Apigenin
111800view15:10, 7 September 2020DeSladded ID for Betulinic acid
111799view15:09, 7 September 2020DeSladded ID for bupivacine (assumed this should be bupivacaine, as wikipedia suggests)
111798view15:07, 7 September 2020DeSladded ID for cauleprin (assumed this should be caulerpin, as reference suggests)
111796view14:48, 7 September 2020DeSladded ID for eugenol
111795view14:44, 7 September 2020DeSladded ID for Glyceollin
111794view14:43, 7 September 2020DeSladded ID for Homocysteine sulfinic acid
111793view14:38, 7 September 2020DeSladded ID for Isorhamnetin
111792view14:36, 7 September 2020DeSladded ID for oxytocin
111791view14:28, 7 September 2020DeSladded ID for quericin (assumed this should be quercetin, as reference suggests)
111790view14:26, 7 September 2020DeSladded ID for ramipril
111789view14:24, 7 September 2020DeSlremoved name as ID for Theasinensins
110018view19:19, 12 April 2020Keshavconnections
110016view19:13, 12 April 2020KeshavInteractions
109756view18:30, 30 March 2020KeshavOntology Term : 'cancer' added !
109755view18:29, 30 March 2020KeshavOntology Term : 'calcium/calcium-mediated signaling pathway' added !
109750view17:53, 30 March 2020KeshavTitle
109749view17:49, 30 March 2020KeshavNew pathway

External references


View all...
NameTypeDatabase referenceComment
ACACAProteinNP_942131.1 (NCBI Protein)
AKTProteinNP_001014431.1 (NCBI Protein)
ARHGEF7GeneProduct8874 (Entrez Gene)
AdropinProteinIPR034461 (InterPro)
ApigeninMetaboliteCHEBI:18388 (ChEBI)
Betulinic acidMetaboliteCHEBI:3087 (ChEBI)
BupivacaineMetaboliteCHEBI:31322 (ChEBI)
CALM1GeneProduct801 (Entrez Gene)
CAMK1GeneProduct8536 (Entrez Gene)
CAMK4GeneProduct814 (Entrez Gene)
CAMKK2GeneProduct10645 (Entrez Gene)
CHRM3GeneProduct1131 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CaulerpinMetaboliteCHEBI:80923 (ChEBI)
DRP1GeneProduct10059 (Entrez Gene)
EIF4EBP1ProteinNP_004086.1 (NCBI Protein)
EP300GeneProduct2033 (Entrez Gene)
EugenolMetaboliteCHEBI:4917 (ChEBI)
FIS1GeneProduct51024 (Entrez Gene)
FOXO3AProteinNP_001446.1 (NCBI Protein)
GDH1 GeneProduct854557 (Entrez Gene)
GIT1GeneProduct28964 (Entrez Gene)
GlyceollinMetaboliteCHEBI:16470 (ChEBI)
HDCA4GeneProduct9759 (Entrez Gene)
HMOX1GeneProduct3162 (Entrez Gene)
Homocysteine sulfinic acidMetaboliteCHEBI:137439 (ChEBI)
Hydrogen sulphideGeneProduct
ICAM1GeneProduct3383 (Entrez Gene)
IRS-1ProteinNP_005535.1 (NCBI Protein)
IsorhamnetinMetaboliteCHEBI:6052 (ChEBI)
Laminar shear stressLaminar shear stress (Other)
MAFGeneProduct4094 (Entrez Gene)
MAP1LC3AGeneProduct84557 (Entrez Gene)
MAPK14 ProteinNP_001306.1 (NCBI Protein)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3 GeneProduct5595 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
NFATC2GeneProduct4773 (Entrez Gene)
NOS1GeneProduct4842 (Entrez Gene)
NOS3 ProteinNP_000594.2 (NCBI Protein)
NRF2GeneProduct4780 (Entrez Gene)
OxytocinMetaboliteCHEBI:7872 (ChEBI)
PAK1 GeneProduct5058 (NCBI Protein)
PRKAA2GeneProductNP_006243.2 (NCBI Protein)
PRKCAProteinNP_002728.1 (NCBI Protein)
Poly unsaturated fatty acidsGeneProduct
ProteinProtein5894 (Entrez Gene)
Pulsed electric fieldGeneProduct
QuercetinMetaboliteCHEBI:16243 (ChEBI)
RAC1GeneProduct5879 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RPTORGeneProduct57521 (Entrez Gene)
RamiprilMetaboliteCHEBI:8774 (ChEBI)
SIRT1 GeneProduct23411 (Entrez Gene)
SMC1GeneProduct8243 (Entrez Gene)
SQSTM1GeneProduct8878 (Entrez Gene)
STIM1GeneProduct6786 (Entrez Gene)
TBC1D4 ProteinNP_001273587.1 (NCBI Protein)
TSC1GeneProduct7248 (Entrez Gene)
TSC2ProteinNP_000539.2 (NCBI Protein)
VCAM1GeneProduct7412 (Entrez Gene)
WFS1GeneProduct7466 (Entrez Gene)
Withdrawal of essential amino acidsGeneProduct

Annotated Interactions

No annotated interactions

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