Host-pathogen interaction of human corona viruses - ER stress (Homo sapiens)

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1global proteintranslationXBP1UmRNAMHV infectionIRE1 (ERN1)dependent mRNA decayER protein chaperonesLipid biosynthesisER-associated degradation...SARS, 229E, MHVdouble strandedRNAunfolded proteinER-associatedmRNACRE (cAMP response element)unfolded proteinsER luminalvirus proteinProsurvival genes(Bcl2...)UsplicingAmino acid synthesisAntioxidant responseApoptosis ...PP1SARSdephosphorylateER protein chaperones ..Virus type/speciesUbiquitinationPhosphorylationEIF2APPP1R3CApoptosisPPP1R14APPP1R14DPPP1R2CEBPBPPP1R16ACEBPECEBPDPPP1R1AEIF2AK3CEBPAPP1PPP1R14CPPP1R9BPPP1R10PPP1R1BXBP1PPP1R3BPPP1R12CPPP1R11PPP1R3EPPP1R7PPP1R9AMAPK9PPP1R1CPPP1R15APPP1CAPPP1R12A8aERN1PPP1R3GPPP1R8CEBPGMAPK8PPP1R14BMBTPS1EPPP1CCPPP1R12Bnsp15CEBPZATF6PPP1R15BPPP1R13BMAPK10PPP1R15APPP1CBPPP1R3APPP1R3DATF4PPP1R16BDDIT3PPP1R3FEIF2AEIF2AK2EIF2AK2EIF2AK2MERS4aSARS, OC43MHV, IBV infectionEIF2AK3EIF2AK3SARS, IBVinfectionERN1ERN1S(MHV, IBV), OC43infectionXBP1USXBP1SmRNASARSATF6ATF6MBTPS28bCytosolicNucleusC/EBPUPRE/ERSE(Unfolded protein response element, ER stress response element)ERSE/ERSE-II(ER stress response element)DNAunfolded proteinsunfolded proteinsMERS


Description

ER stress due to unfolded protein response. Figure 6 of Fung and Liu 2019.

Quality Tags

Ontology Terms

 

Bibliography

  1. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
110207view10:56, 24 April 2020Fehrhartadded legend
110195view19:10, 23 April 2020EgonwChanged the DataNote @Type of proteins to Protein
109975view18:19, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109850view11:39, 2 April 2020Fehrhartchanged virus protein visualization
109817view14:51, 1 April 2020Fehrhartconnected lines
109816view14:49, 1 April 2020Fehrhartadded virus protein E ID
109705view14:38, 29 March 2020FehrhartOntology Term : 'endoplasmic reticulum stress - the unfolded protein response pathway' added !
109704view14:37, 29 March 2020FehrhartOntology Term : 'disease pathway' added !
109703view14:37, 29 March 2020FehrhartOntology Term : 'viral infectious disease' added !
109702view14:37, 29 March 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
109701view14:36, 29 March 2020Fehrhartwork in progress
109700view14:19, 29 March 2020Fehrhartongoing work
109699view14:11, 29 March 2020FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4aProtein
8aProtein
8bProtein
ATF4GeneProductENSG00000128272 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
CEBPAGeneProductENSG00000245848 (Ensembl)
CEBPBGeneProductENSG00000172216 (Ensembl)
CEBPDGeneProductENSG00000221869 (Ensembl)
CEBPEGeneProductENSG00000092067 (Ensembl)
CEBPGGeneProductENSG00000153879 (Ensembl)
CEBPZGeneProductENSG00000115816 (Ensembl)
DDIT3GeneProductENSG00000175197 (Ensembl) CHOP
EIF2AGeneProductENSG00000144895 (Ensembl)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2AK3GeneProductENSG00000172071 (Ensembl) PERK
EProteinP59637 (Uniprot-TrEMBL)
ERN1GeneProductENSG00000178607 (Ensembl) IRE1
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MBTPS1GeneProductENSG00000140943 (Ensembl)
MBTPS2GeneProductENSG00000012174 (Ensembl)
PP1GeneProduct
PPP1CAGeneProductENSG00000172531 (Ensembl)
PPP1CBGeneProductENSG00000213639 (Ensembl)
PPP1CCGeneProductENSG00000186298 (Ensembl)
PPP1R10GeneProductENSG00000204569 (Ensembl)
PPP1R11GeneProductENSG00000204619 (Ensembl)
PPP1R12AGeneProductENSG00000058272 (Ensembl)
PPP1R12BGeneProductENSG00000077157 (Ensembl)
PPP1R12CGeneProductENSG00000125503 (Ensembl)
PPP1R13BGeneProductENSG00000088808 (Ensembl)
PPP1R14AGeneProductENSG00000167641 (Ensembl)
PPP1R14BGeneProductENSG00000173457 (Ensembl)
PPP1R14CGeneProductENSG00000198729 (Ensembl)
PPP1R14DGeneProductENSG00000166143 (Ensembl)
PPP1R15AGeneProductENSG00000087074 (Ensembl) GADD34
PPP1R15BGeneProductENSG00000158615 (Ensembl)
PPP1R16AGeneProductENSG00000160972 (Ensembl)
PPP1R16BGeneProductENSG00000101445 (Ensembl)
PPP1R1AGeneProductENSG00000135447 (Ensembl)
PPP1R1BGeneProductENSG00000131771 (Ensembl)
PPP1R1CGeneProductENSG00000150722 (Ensembl)
PPP1R2GeneProductENSG00000184203 (Ensembl)
PPP1R3AGeneProductENSG00000154415 (Ensembl)
PPP1R3BGeneProductENSG00000173281 (Ensembl)
PPP1R3CGeneProductENSG00000119938 (Ensembl)
PPP1R3DGeneProductENSG00000132825 (Ensembl)
PPP1R3EGeneProductENSG00000235194 (Ensembl)
PPP1R3FGeneProductENSG00000049769 (Ensembl)
PPP1R3GGeneProductENSG00000219607 (Ensembl)
PPP1R7GeneProductENSG00000115685 (Ensembl)
PPP1R8GeneProductENSG00000117751 (Ensembl)
PPP1R9AGeneProductENSG00000158528 (Ensembl)
PPP1R9BGeneProductENSG00000108819 (Ensembl)
XBP1GeneProductENSG00000100219 (Ensembl)
nsp15Protein

Annotated Interactions

No annotated interactions

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