ER stress response in Coronavirus infection (Homo sapiens)

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1, 324UnfoldedproteinNucleusGolgiProsurvival genesMERS 4aER-associatedmRNAER lumenSSplicingER protein chaperonesdsRNAGlobal proteintranslationAmino acid synthesisAntioxidant responseApoptosisER protein chaperonesLipid biosynthesisER-associated degradationMVH infectionCRES1PPPP1CBS2PApoptosisHRIERN1ATF6nsp15ATF4SARS 8abMAPK8PKRRIDDBCL2GCN2XBP1PPP1CCPEIF2APPGADD34CHOPPERKSARS, IBV infectionSARS, OC43,MHV, IBV infectionERN1PUnfoldedproteinERN1PXBP1uHSPA5ATF6UnfoldedproteinATF6ATF6-p50SARS EHSPA5HSPA5HSPA5CytosolHSPA5HSPA5PERKPPERKPEIF2APKRCHOPXBP1dsRNAOC43 infectionSARS, 229E, MHVPKRPC/EBPUPREERSEERSE-IIERSEPPP1CA


Induction and modulation of unfolded protein response by HCoV infection. Schematic diagram showing the three branches of UPR signaling pathway activated and regulated by HCoV infection.

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Ontology Terms



  1. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia
  2. Cui W, Li J, Ron D, Sha B; ''The structure of the PERK kinase domain suggests the mechanism for its activation.''; Acta Crystallogr D Biol Crystallogr, 2011 PubMed Europe PMC Scholia
  3. David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, et al.; '' A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug Repurposing''; BioRxiv, 2020
  4. Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL; ''ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.''; Mol Cell, 2000 PubMed Europe PMC Scholia


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110677view23:52, 27 May 2020KhanspersModified title
110676view23:51, 27 May 2020KhanspersModified description
110675view23:51, 27 May 2020Khanspersadded S1P, S2P and missing xrefs
110674view23:27, 27 May 2020KhanspersAdded phospho sites
110673view22:22, 27 May 2020Khanspersfixed typo
110672view22:16, 27 May 2020Khanspersadded details and viral proteins
110670view18:45, 27 May 2020KhanspersModified title
110669view18:40, 27 May 2020Khanspersupdated to protein ids, fixed ER
110665view00:29, 27 May 2020KhanspersModified title
110664view00:28, 27 May 2020Khanspersadded third arm, location etc
110630view23:33, 22 May 2020Khanspersspecified interactions
110629view23:19, 22 May 2020Khanspersadded content
110451view22:43, 12 May 2020Khansperscleared up names, added interactions
110198view20:38, 23 April 2020EgonwTyped proteins as Type="Protein"
109971view18:17, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109855view13:41, 2 April 2020MaintBotThe label just black.
109854view13:40, 2 April 2020MaintBotStyled the virus node.
109726view21:10, 29 March 2020EgonwAdded a Wikidata identifier for nsp15
109643view19:23, 27 March 2020AlexanderPicoOntology Term : 'viral infectious disease' added !
109632view18:27, 27 March 2020AlexanderPicoOntology Term : 'stress response pathway' added !
109631view18:27, 27 March 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
109630view18:26, 27 March 2020AlexanderPicoOntology Term : 'disease pathway' added !
109618view17:18, 27 March 2020Khanspersadded lit ref
109615view16:56, 27 March 2020KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
ATF4ProteinP18848 (Uniprot-TrEMBL)
ATF6-p50ProteinP18850 (Uniprot-TrEMBL)
ATF6ProteinP18850 (Uniprot-TrEMBL)
ApoptosisPathwayWP354 (WikiPathways)
BCL2ProteinP10415 (Uniprot-TrEMBL)
CHOPProteinP35638 (Uniprot-TrEMBL)
EIF2AProteinQ53XC0 (Uniprot-TrEMBL)
ERN1ProteinO75460 (Uniprot-TrEMBL)
GADD34ProteinO75807 (Uniprot-TrEMBL)
GCN2ProteinQ9H492 (Uniprot-TrEMBL)
HRIProteinQ9BQI3 (Uniprot-TrEMBL)
HSPA5ProteinP11021 (Uniprot-TrEMBL)
MAPK8ProteinP45983 (Uniprot-TrEMBL)
MERS 4aProtein
PERKProteinQ9NZJ5 (Uniprot-TrEMBL)
PKRProteinP19525 (Uniprot-TrEMBL)
PPP1CAProteinP62136 (Uniprot-TrEMBL)
PPP1CBProteinP62140 (Uniprot-TrEMBL)
PPP1CCProteinP36873 (Uniprot-TrEMBL)
S1PProteinQ14703 (Uniprot-TrEMBL)
S2PProteinO43462 (Uniprot-TrEMBL)
SARS 8abGeneProduct
SARS EGeneProduct
XBP1ProteinP17861 (Uniprot-TrEMBL)
XBP1uProteinP17861 (Uniprot-TrEMBL)
nsp15ProteinQ87917579 (Wikidata)

Annotated Interactions

No annotated interactions

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