ER stress response in Coronavirus infection (Homo sapiens)

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1, 324UnfoldedproteinNucleusGolgiProsurvival genesMERS 4aER-associatedmRNAER lumenSSplicingER protein chaperonesdsRNAGlobal proteintranslationAmino acid synthesisAntioxidant responseApoptosisER protein chaperonesLipid biosynthesisER-associated degradationMVH infectionCRES1PPPP1CBS2PApoptosisHRIERN1ATF6nsp15ATF4SARS 8abMAPK8PKRRIDDBCL2GCN2XBP1PPP1CCPEIF2APPGADD34CHOPPERKSARS, IBV infectionSARS, OC43,MHV, IBV infectionERN1PUnfoldedproteinERN1PXBP1uHSPA5ATF6UnfoldedproteinATF6ATF6-p50SARS EHSPA5HSPA5HSPA5CytosolHSPA5HSPA5PERKPPERKPEIF2APKRCHOPXBP1dsRNAOC43 infectionSARS, 229E, MHVPKRPC/EBPUPREERSEERSE-IIERSEPPP1CA


Description

Induction and modulation of unfolded protein response by HCoV infection. Schematic diagram showing the three branches of UPR signaling pathway activated and regulated by HCoV infection.

Quality Tags

Ontology Terms

 

Bibliography

  1. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia
  2. Cui W, Li J, Ron D, Sha B; ''The structure of the PERK kinase domain suggests the mechanism for its activation.''; Acta Crystallogr D Biol Crystallogr, 2011 PubMed Europe PMC Scholia
  3. David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, et al.; '' A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug Repurposing''; BioRxiv, 2020
  4. Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL; ''ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.''; Mol Cell, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110677view23:52, 27 May 2020KhanspersModified title
110676view23:51, 27 May 2020KhanspersModified description
110675view23:51, 27 May 2020Khanspersadded S1P, S2P and missing xrefs
110674view23:27, 27 May 2020KhanspersAdded phospho sites
110673view22:22, 27 May 2020Khanspersfixed typo
110672view22:16, 27 May 2020Khanspersadded details and viral proteins
110670view18:45, 27 May 2020KhanspersModified title
110669view18:40, 27 May 2020Khanspersupdated to protein ids, fixed ER
110665view00:29, 27 May 2020KhanspersModified title
110664view00:28, 27 May 2020Khanspersadded third arm, location etc
110630view23:33, 22 May 2020Khanspersspecified interactions
110629view23:19, 22 May 2020Khanspersadded content
110451view22:43, 12 May 2020Khansperscleared up names, added interactions
110198view20:38, 23 April 2020EgonwTyped proteins as Type="Protein"
109971view18:17, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109855view13:41, 2 April 2020MaintBotThe label just black.
109854view13:40, 2 April 2020MaintBotStyled the virus node.
109726view21:10, 29 March 2020EgonwAdded a Wikidata identifier for nsp15
109643view19:23, 27 March 2020AlexanderPicoOntology Term : 'viral infectious disease' added !
109632view18:27, 27 March 2020AlexanderPicoOntology Term : 'stress response pathway' added !
109631view18:27, 27 March 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
109630view18:26, 27 March 2020AlexanderPicoOntology Term : 'disease pathway' added !
109618view17:18, 27 March 2020Khanspersadded lit ref
109615view16:56, 27 March 2020KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF4ProteinP18848 (Uniprot-TrEMBL)
ATF6-p50ProteinP18850 (Uniprot-TrEMBL)
ATF6ProteinP18850 (Uniprot-TrEMBL)
ApoptosisPathwayWP354 (WikiPathways)
BCL2ProteinP10415 (Uniprot-TrEMBL)
CHOPProteinP35638 (Uniprot-TrEMBL)
EIF2AProteinQ53XC0 (Uniprot-TrEMBL)
ERN1ProteinO75460 (Uniprot-TrEMBL)
GADD34ProteinO75807 (Uniprot-TrEMBL)
GCN2ProteinQ9H492 (Uniprot-TrEMBL)
HRIProteinQ9BQI3 (Uniprot-TrEMBL)
HSPA5ProteinP11021 (Uniprot-TrEMBL)
MAPK8ProteinP45983 (Uniprot-TrEMBL)
MERS 4aProtein
PERKProteinQ9NZJ5 (Uniprot-TrEMBL)
PKRProteinP19525 (Uniprot-TrEMBL)
PPP1CAProteinP62136 (Uniprot-TrEMBL)
PPP1CBProteinP62140 (Uniprot-TrEMBL)
PPP1CCProteinP36873 (Uniprot-TrEMBL)
RIDDPathway
SProtein
S1PProteinQ14703 (Uniprot-TrEMBL)
S2PProteinO43462 (Uniprot-TrEMBL)
SARS 8abGeneProduct
SARS EGeneProduct
XBP1ProteinP17861 (Uniprot-TrEMBL)
XBP1uProteinP17861 (Uniprot-TrEMBL)
nsp15ProteinQ87917579 (Wikidata)

Annotated Interactions

No annotated interactions

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