Endothelin Pathway (Homo sapiens)

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KSR1S39249GRB245SOS12EGFRY845Y1173Y1068PCPCOL1A2FGF2ACTR1AARHGEF7RGS3FHL2ANXA7GNAQACTR2HLA-AGALNT1GSNBCL2COL9A1MYBPC3NAA50RAB5CMMP9CREG1IPK1ITGB3TIMP3 VIMGJC1ABHD3HTATSF1SMAD5FLNCTPM1CTNNB1ARRB1CAPZBCALD1MINK1IGFBP4COL4A1DAZAP2BCAR1IL1BDLATCOL1A3GOLGB1PLCB1NPPACOL1A4KDM5BCOMPCCN2SP4RAC1RUNX1CXCL8IL11EPHA2MMP1FLNBNQO1ITGA5FNDC3BNOL8DNAJC10ADAM19ADAM12ITGB3TNFVIL1PLOD2GGA2BCAR3CTNNB1COL5A1NPPBGULP1WIPF1IGFBP5FOXK2CDH1MYL12BACTR3NKX2-5BMI1ZFYVE16ATRXSDC1MPP5VCANPPP1R12AGAB1STOMTWIST1MARCKSSNAI1ITGB3TRIOBPDNAJC12COL7A1FNDC1 ITGA2ISCA1EMC1THBS1ACTG2CRYZL1B3GNT2FASTKD1EZRRDXMAP3K2MMP3TNS1GSTA5WNK1ARL6IP5ATP6V1HHOPXYWHAQIRX4ARPC4TAGLN2MMP2CCNB1ITGB1BP1NAA16ARRB1KLHL20GJA5CCND1MED12CDH1ITGB1HIF1AITGA2ACTA2SSH1PTGS2CCL2COL1A1TPM4P4HBZNF131CDH2EIF5BMPPED2WWTR1TRAFD1MYO1BZNF136PTK2BE2F3PXNACTA21815379S195525T1825662540Y24926, 79126431Y16538G-protein dependentEDN1EDN1EDN1EDNRA62EDNRBROCK14RAC15PAK15PMAPK8T183RHOC19, 7211DAG1PLCB168PKC5Ca2+SRCT41875T416KRAS57RAF12MAP2K1S21744MAP2K28S221MAPK131T202MAPK331Y204NFKBIA78RELAS36S3278S536NFKB1ARHGAP3536S1150HIF1A3PIK3CAP70ILK17AKT141, 71, 74T308S473β-arrestin dependentLIMK11T508T505MTOR77S2448 PRKACA10CREB47, 53PPPP3CA30NFATC176CREB1S13353MAPK14P7, 26RELA56NFKB1NUCPNURPS6KB127PHSPB146S85GATA463MEF2A6CALM158CASP879Blood vesselcontractionRPS6S236S23577ATF221CDC425SHC145PIRS1PNOS337, 50S1177S1179PRKCA57IP3ARF620ELK1P33ATF133S63RPS6KA2S38133RPS6KA3T577 33MAPK919, 32, 67Y185JUN1S73S63CPNUEP2EP4CFL1S311, 73ActinpolymerizationCytoskeletalpolymerisationPulmonary hypertensionMMP2MMP9CellinvasionCell invasionVCAM1CX3CL1Renal fibrosisPTGS2CXCL1CXCL8Metastasisand tumorprogressionMCAMInvasionand metastasisMYH11Smooth muscledifferentiationCell migrationIL6GATA4MMP13FOSJUNEGR1CSF2CDH1CTNND1CTNNB1CCND1COX1COX2Cell survivaland angiogenesisEDN3YAP1P60Epithelial to mesenchymaltransition (EMT)SRCSRC40ARRB1Y418Y41611, 40SRCARRB1Y418Y416EDNRAARHGEF11HypoxiaELK1AXIN133, 61GSK3B4040PTCF4P40ADAM1724ADIPOQMLCK12PPP1R14AT3818PPP1R12AT695T85318GNAS52JAK1STAT3P3939, 53Y705CHUK77IKBKBS180S18777KCNK335MMP14MSNECM contractionRAP1GAP25RHOAABL123Y41229SREEP30014CREB1S13353ATF133S63ATF2S7321BADS112CALD1S790S75969CAMK2A14T286CAMK2GHDAC5T30534HDAC599PCDKN1BS1048CDK248CFL2P22PTK2Y397AXIN1EIF2BP42FLI129T312FOSS3316FOXO3T3228FYN65Y416MLC43, 51S19T18BCL2Lung fibrosisCellular proliferation, migration and contraction in colon cancer adjacent fibroblastsCCS differentiationEP300VEGFANOS3NO accumulationCX3CL1CTNND179 Cardiac hypertrophyLEPRChemo protectionBrain inflamation disordersInflammationCPNUCPNUCCL2CXCL1GLSSHC128CTNNB1S3659ARHGEF75ARHGEF7COL1A25GNA13GNA12GNAQGNA13GNA12LEGENDLigandReceptorPositive regulation of gene expressionNegative regulation of gene expressionTranslocationInhibitionPlasma membraneCytoplasmNucleusPMCPNUInduced CatalysisActivationProteinMolecular associationProteinEnzyme complexPLA2G1B54Leads to , through unknown or not reported/studied intermediatesSmall moleculesCytoplasmNucleusmRNA