Endothelin pathway (Homo sapiens)

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KSR1S39255GRB276SOS115EGFRPY1173Y1068Y845CPACTR1AATP6V1HITGA5BMI1CCNB1ACTR2EPHA2ZNF131COL1A3PLOD2COL9A1MYL12BCOL1A4FHL2ACTA2HIF1AWIPF1MARCKSCOL1A2TNS1COL5A1RAC1ARL6IP5ADAM19COL1A1CXCL8GALNT1TNFGJA5FASTKD1NPPANPPBGGA2TRAFD1RDXSNAI1CDH2CDH1FLNCVIMCTNNB1E2F3COMPNOL8HOPXACTR3ITGB3NAA16FLNBVCANSTOMTPM4PXNANXA7SSH1MAP3K2HLA-AMMP9MINK1IPK1CTNNB1ARPC4ACTA2PPP1R12AITGB3ARRB1KDM5BEZRIRX4SDC1IGFBP5MYO1BDAZAP2FNDC1 ISCA1MMP3ZNF136EMC1CRYZL1TIMP3 FGF2MMP2THBS1ITGB3EIF5BDNAJC12CCL2CCN2IGFBP4MED12MMP1SP4SMAD5BCAR1COL7A1ZFYVE16ACTG2WWTR1CDH1ADAM12WNK1ARRB1GSTA5MPPED2ITGA2COL4A1KLHL20FOXK2FNDC3BGULP1TWIST1VIL1GAB1GNAQTPM1CREG1CALD1IL11ABHD3ITGB1BP1P4HBMPP5BCAR3DLATTAGLN2NAA50ARHGEF7TRIOBPYWHAQDNAJC10IL1BGOLGB1NQO1CCND1ITGA2PLCB1PTGS2B3GNT2RAB5CRGS3RUNX1BCL2GSNATRXHTATSF1MYBPC3PTK2BNKX2-5CAPZBITGB1GJC1706645775S19Y1652918, 31664873167T1851Y2496658G-protein dependentEDN1EDN1EDN1EDNRA79EDNRBROCK172RAC160PAK160PMAPK8T183RHOC19, 2556DAG1PLCB152PKC60Ca2+SRC46T416T418KRAS68RAF115MAP2K1S21778MAP2K216S221MAPK14Y187T185MAPK34Y204T202NFKBIARELAS32S365050S536NFKB1ARHGAP3543S1150HIF1A7PIK3CAP41ILK45AKT120, 21, 63T308S473β-arrestin dependentLIMKT508T50556MTORS2448 64PRKACA2CREB30, 36PPPP3CA27NFATC112CREB1S13336MAPK1418, 28PRELA74NFKB1NUCPNURPS6KB137PHSPB126S85GATA49MEF2A1CALM138CASP831Blood vesselcontractionRPS664S235S236ATF239CDC4260SHC1P76IRS1PNOS3S11793, 53S1177PRKCA68IP3ARF659ELK171PATF1S6371RPS6KA271S381RPS6KA3T577 71MAPK9Y18519, 33, 40JUN62S63S73CPNUEP2EP4CFL124, 56S3ActinpolymerizationCytoskeletalpolymerisationPulmonary hypertensionMMP2MMP9CellinvasionCell invasionVCAM1CX3CL1Renal fibrosisPTGS2CXCL1CXCL8Metastasisand tumorprogressionMCAMInvasionand metastasisMYH11Smooth muscledifferentiationCell migrationIL6GATA4MMP13FOSJUNEGR1CSF2CDH1CTNND1CTNNB1CCND1COX1COX2Cell survivaland angiogenesisEDN3YAP114PEpithelial to mesenchymaltransition (EMT)SRCSRC70ARRB1Y416Y41856, 70SRCY418Y416ARRB1EDNRAARHGEF11HypoxiaELK165, 71AXIN170GSK3BP70TCF470PADAM175ADIPOQMLCK58PPP1R14APPP1R12A29T3829T695T853GNAS42JAK1PSTAT344Y70536, 44CHUKS18064IKBKB64S187KCNK3MMP148MSNECM contractionRAP1GAPRHOA6613ABL122Y412SREEP30047CREB1S13336ATF171S63ATF2S7339BADS112CALD16S790S759CAMK2A47T286CAMK2GHDAC5T3055417HDAC517PCDKN1BS1069CDK269CFL210PPTK2Y397AXIN1EIF2B32PFLI122T312FOSS3334FOXO3T3211FYN49Y416MLCS19T1823, 61BCL2Lung fibrosisCellular proliferation, migration and contraction in colon cancer adjacent fibroblastsCCS differentiationEP300VEGFANOS3NO accumulationCX3CL1CTNND1 Cardiac hypertrophy31LEPRChemo protectionBrain inflamation disordersInflammationCPNUCPNUCCL2CXCL1GLSSHC1S3611CTNNB135ARHGEF7ARHGEF76060COL1A2GNA13GNA12GNAQGNA13GNA12LEGENDLigandReceptorPositive regulation of gene expressionNegative regulation of gene expressionTranslocationInhibitionPlasma membraneCytoplasmNucleusPMCPNUInduced CatalysisActivationProteinMolecular associationProteinEnzyme complexPLA2G1B73Leads to , through unknown or not reported/studied intermediatesSmall moleculesCytoplasmNucleusmRNA