Endothelin Pathway (Homo sapiens)

From WikiPathways

Jump to: navigation, search
KSR165S392GRB2SOS15426EGFRPY1068Y845Y1173CPDNAJC10ACTA2NOL8ARPC4COL5A1FLNCTIMP3 COL1A3ACTA2CDH1RAC1CAPZBCRYZL1E2F3EIF5BHOPXPTK2BADAM19PLOD2NKX2-5HIF1ADNAJC12GSTA5RUNX1GALNT1MPPED2ZNF136FNDC1 COL1A2ITGB1ITGB3VIL1MARCKSFASTKD1SNAI1ITGA2TRAFD1IL1BGULP1MED12MMP2PXNACTR2WNK1STOMNAA16KDM5BEZRMMP9PPP1R12AFOXK2ITGA2CREG1ISCA1TAGLN2ATP6V1HCOL9A1IL11WIPF1MYBPC3COL1A1ACTR1AMYL12BZNF131CALD1SSH1TPM4NPPAMPP5MMP3SP4ZFYVE16GJA5COL4A1IRX4TWIST1KLHL20DLATWWTR1GJC1CCND1MMP1ITGB1BP1BMI1BCAR3GGA2FHL2ITGA5TPM1BCL2CTNNB1SDC1ADAM12RAB5CCXCL8TNFMYO1BGNAQNQO1CDH2FLNBSMAD5ATRXCOL7A1CCL2RGS3GSNTNS1ACTG2ACTR3RDXITGB3FNDC3BVCANARRB1BCAR1ITGB3ARHGEF7ARL6IP5GAB1EPHA2THBS1IPK1YWHAQNAA50COL1A4ABHD3COMPMAP3K2HTATSF1MINK1EMC1P4HBCCNB1PLCB1B3GNT2CCN2ANXA7HLA-AARRB1PTGS2GOLGB1CDH1CTNNB1IGFBP5NPPBVIMTRIOBPDAZAP2IGFBP4FGF2Y24934503765335346834T186, 122218S1964Y16521G-protein dependentEDN1EDN1EDN1EDNRA14EDNRBROCK166RAC177PAK1P77MAPK836, 57RHOCT18369DAG1PLCB144PKC77Ca2+SRCT41659T418KRAS24RAF126MAP2K1S21771MAP2K2S2219MAPK1T2023MAPK3Y2043NFKBIAS32S36RELA25S53625NFKB1ARHGAP358S1150HIF1A35PIK3CAP2ILK72AKT1T308S47327, 47, 55b-arrestin dependentLIMK69T508T505MTOR39S2448 PRKACA58CREB15, 67PPPP3CA43NFATC153CREB167S133MAPK1412, 60PRELA56NFKB1NUCPNURPS6KB1P52HSPB1S8563GATA479MEF2A49CALM148CASP86Blood vesselcontractionRPS6S23539S236ATF238CDC4277SHC154PIRS1PNOS3S1177S117910, 19PRKCA24IP3ARF646ELK113PATF1S6313RPS6KA2S38113RPS6KA313T577 MAPK9Y18528, 36, 62JUN73S73S63CPNUEP2EP4CFL1S332, 69ActinpolymerizationCytoskeletalpolymerisationPulmonary hypertensionMMP2MMP9CellinvasionCell invasionVCAM1CX3CL1Renal fibrosisPTGS2CXCL1CXCL8Metastasisand tumorprogressionMCAMInvasionand metastasisMYH11Smooth muscledifferentiationCell migrationIL6GATA4MMP13FOSJUNEGR1CSF2CDH1CTNND1CTNNB1CCND1COX1COX2Cell survivaland angiogenesisEDN3YAP1P23Epithelial to mesenchymaltransition (EMT)SRC21SRCY418ARRB1Y41621, 69SRCY418ARRB1Y416EDNRAARHGEF11HypoxiaELK113, 33AXIN121GSK3BP21TCF4P21ADAM171ADIPOQMLCK50PPP1R14A22PPP1R12AT38T695T85322GNAS75JAK1PSTAT37867, 78Y705CHUKS180IKBKB39S18739KCNK345MMP14MSNECM contractionRAP1GAP34RHOA29ABL17Y412SREEP30070CREB1S13367ATF1S6313ATF238S73BADS112CALD14S790S759CAMK2AT28670CAMK2GHDAC574T30520HDAC5P20CDKN1BS1042CDK2CFL242P16PTK2Y397AXIN1EIF2B76PFLI17T312FOSS3311FOXO341T32FYN40Y416MLCS19T1817, 31BCL2Lung fibrosisCellular proliferation, migration and contraction in colon cancer adjacent fibroblastsCCS differentiationEP300VEGFANOS3NO accumulationCX3CL1CTNND1 Cardiac hypertrophy6LEPRChemo protectionBrain inflamation disordersInflammationCPNUCPNUCCL2CXCL1GLSSHC141CTNNB1S3661ARHGEF777ARHGEF7COL1A277CytoplasmNucleusGNA13GNA12GNAQGNA13GNA12LEGENDLigandReceptorPositive regulation of gene expressionNegative regulation of gene expressionTranslocationInhibitionPlasma membraneCytoplasmNucleusPMCPNUInduced CatalysisActivationProteinMolecular associationProteinEnzyme complexPLA2G1B30Leads to , through unknown or not reported/studied intermediatesSmall moleculesCytoplasmNucleus