Linoleic acid metabolism affected by SARS-CoV-2 (Homo sapiens)

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6124102, 10108101610710, 1591231368Viral binding to ACE2Virus in host cellLysoPC16:0Omega-3oleic acidFADS2Arachidonic acidACE2Linoleoyl-CoAdesaturasemitogen-activated protein kinasepalmitic acidSARS-CoV-2 and COVID-19 PathwayMolecular mechanismstearic acidbishomo-gamma-linolenic acidlinoleic acidCytosolic Phospholipase A2(cPLA2)GlycerophospholipidsOmega-3/Omega-6 FA synthesisLysPE 16:0Cytokine StormImmune reponse to SARS-COV-2Omega-6gamma-linolenic acid1Sars-Cov-2 Viriontrimersurfaceglycoprotein Ssurfaceglycoprotein S11, 14membraneglycoprotein MSARS-CoV-2RNA11nucleocapsidprotein Nenvelopeprotein E1111CoA(18:2(9Z,12Z))CoA(18:3(6Z,9Z,12Z))ACOT28CoA(20:3(8Z,11Z,14Z))88ELOVL2ELOVL5Arachidonoyl-CoA8FADS1surfaceglycoprotein S8


Description

Lipid metabolism alternations that are related to infection by corona viruses. The information comes from the Yan et al. in 2019 in the bibliography, particularly Figure 5. That paper uses the HCoV-229E virus as a model. Note that that is different from the virus that causes the 2020 pandemic SARS-CoV-2. Fig 5 is in turn taken from https://www.kegg.jp/kegg-bin/show_pathway?map00591, which is a very simplified pathway, omitting several steps. The paper mentions that after virus infection many of the metabolites in his figure are increased in concentration. Interestingly, exogenous supplement of LA or AA in HCoV-229E-infected cells significantly suppressed HCoV-229E virus replication and this also happened in MERS-CoV.

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Bibliography

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  1. Sigrist CJ, Bridge A, Le Mercier P; ''A potential role for integrins in host cell entry by SARS-CoV-2.''; Antiviral Res, 2020 PubMed Europe PMC Scholia
  2. Arnardottir H, Pawelzik SC, Öhlund Wistbacka U, Artiach G, Hofmann R, Reinholdsson I, Braunschweig F, Tornvall P, Religa D, Bäck M; ''Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for theCOVID-Omega-FTrial.''; Front Physiol, 2020 PubMed Europe PMC Scholia
  3. Müller C, Hardt M, Schwudke D, Neuman BW, Pleschka S, Ziebuhr J; ''Inhibition of Cytosolic Phospholipase A2α Impairs an Early Step of Coronavirus Replication in Cell Culture.''; J Virol, 2018 PubMed Europe PMC Scholia
  4. Scialo F, Daniele A, Amato F, Pastore L, Matera MG, Cazzola M, Castaldo G, Bianco A; ''ACE2: The Major Cell Entry Receptor for SARS-CoV-2.''; Lung, 2020 PubMed Europe PMC Scholia
  5. Yan B, Chu H, Yang D, Sze KH, Lai PM, Yuan S, Shuai H, Wang Y, Kao RY, Chan JF, Yuen KY; ''Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication.''; Viruses, 2019 PubMed Europe PMC Scholia
  6. Paces J, Strizova Z, Smrz D, Cerny J; ''COVID-19 and the immune system.''; Physiol Res, 2020 PubMed Europe PMC Scholia
  7. Nakazato Y, Sedor JR; ''IL-1 alpha increases arachidonyl-CoA: lysophospholipid acyltransferase activity and stimulates [3H]arachidonate incorporation into phospholipids in rat mesangial cells.''; Life Sci, 1992 PubMed Europe PMC Scholia
  8. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  9. Grimes JM, Grimes KV; ''p38 MAPK inhibition: A promising therapeutic approach for COVID-19.''; J Mol Cell Cardiol, 2020 PubMed Europe PMC Scholia
  10. Casari I, Manfredi M, Metharom P, Falasca M; ''Dissecting lipid metabolism alterations in SARS-CoV-2.''; Prog Lipid Res, 2021 PubMed Europe PMC Scholia
  11. Kandeel M, Ibrahim AA, Fayez M, Al-Nazawi M; ''From SARS and MERS CoVs to SARS-CoV-2: moving toward more biased codon usage in viral structural and non-structural genes.''; J Med Virol, 2020 PubMed Europe PMC Scholia
  12. Goc A, Niedzwiecki A, Rath M; ''Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry.''; Sci Rep, 2021 PubMed Europe PMC Scholia
  13. Miao H, Chen L, Hao L, Zhang X, Chen Y, Ruan Z, Liang H; ''Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes.''; Sci Rep, 2015 PubMed Europe PMC Scholia
  14. Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D; ''Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.''; Cell, 2020 PubMed Europe PMC Scholia
  15. Hathaway D, Pandav K, Patel M, Riva-Moscoso A, Singh BM, Patel A, Min ZC, Singh-Makkar S, Sana MK, Sanchez-Dopazo R, Desir R, Fahem MMM, Manella S, Rodriguez I, Alvarez A, Abreu R; ''Omega 3 Fatty Acids and COVID-19: A Comprehensive Review.''; Infect Chemother, 2020 PubMed Europe PMC Scholia
  16. Joshi C, Jadeja V, Zhou H; ''Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
122756view16:04, 10 May 2022EgonwMade a pathway clickable
121908view10:24, 8 March 2022CedricPluisfix positions
121907view10:23, 8 March 2022CedricPluisfix interactions
121906view10:22, 8 March 2022CedricPluisfix positions
121904view10:18, 8 March 2022CedricPluisfix interactions
121901view10:13, 8 March 2022CedricPluisarrows changed
121831view09:19, 7 March 2022BramMennenInteraction lines were changed to make the pathway easier to understand
121823view06:50, 7 March 2022EgonwAssuming a typo in LipidMaps identifier: PG -> GP
121639view08:11, 23 February 2022CedricPluischange reference
121628view10:48, 22 February 2022CedricPluisModified title
121627view10:47, 22 February 2022CedricPluisarrow change
121619view09:53, 22 February 2022CedricPluisstearic acid and cytokine storm
121618view09:52, 22 February 2022CedricPluislay-out
121617view09:51, 22 February 2022CedricPluislay-out
121616view09:42, 22 February 2022CedricPluisposition changes
121615view09:38, 22 February 2022CedricPluisposition changes
121611view09:17, 22 February 2022Liekevandenbogaart-
121610view09:16, 22 February 2022CedricPluisAddition of data node pathway covid immune response
121348view08:56, 16 February 2022CedricPluisfix interactions
121347view08:54, 16 February 2022CedricPluisfix interactions
121342view14:52, 15 February 2022CedricPluisconnect lines
121340view13:02, 15 February 2022CedricPluisCPLA2 activation by MAP kinase
121339view13:01, 15 February 2022CedricPluisActivation of MAP kinase
121338view12:36, 15 February 2022CedricPluisMAP kinase
121336view12:16, 15 February 2022CedricPluisace-2
121335view12:13, 15 February 2022CedricPluisace-2 binding and inhibition by produced fatty acids
121333view12:08, 15 February 2022CedricPluisrole of formed fatty acids added
121332view12:03, 15 February 2022CedricPluisRole of omega-3 and omega-6 added
121331view11:53, 15 February 2022CedricPluisChanges in virus structure and addition of the formation of cytokine storm by AA
121243view08:36, 14 February 2022CedricPluis
121242view08:35, 14 February 2022CedricPluis
121230view11:49, 13 February 2022EgonwModified description
119386view16:18, 25 June 2021EgonwNot a mim-conversion
118839view09:19, 2 June 2021EweitzOntology Term : 'DOID:934' removed !
118838view09:19, 2 June 2021EweitzOntology Term : 'Coronavirus infectious disease' added !
118052view10:32, 24 May 2021EweitzModified title
115866view16:12, 18 March 2021DeSlAdded shape around PW node
115864view16:08, 18 March 2021DeSlAdded missing metabolites for dashed lines
111153view08:33, 21 July 2020EgonwMade the pathway clickable
110787view09:11, 5 June 2020DeSlModified title
110786view08:57, 5 June 2020DeSlModified description
110785view08:56, 5 June 2020DeSlAdded lit ref for stimulation of cPLA2
110784view08:55, 5 June 2020DeSlUpdated title again (was accidentally overwritten).
110783view08:53, 5 June 2020DeSlAdded details on how HCoV-229E is related to lipid metabolism alterations.
110457view08:40, 13 May 2020Mkutmonfixed unconnected lines, layout
110338view19:18, 6 May 2020EgonwMade the full membrane visible
109709view14:45, 29 March 2020FehrhartOntology Term : 'lipid metabolic pathway' added !
109708view14:44, 29 March 2020FehrhartOntology Term : 'viral infectious disease' added !
109707view14:44, 29 March 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
109602view22:38, 26 March 2020EveloModified title

External references

DataNodes

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NameTypeDatabase referenceComment
ACE2GeneProductENSG00000130234 (Ensembl)
ACOT2GeneProductENSG00000119673 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Arachidonoyl-CoAMetaboliteLMFA07050288 (LIPID MAPS) aka CoA(20:4)
CoA(18:2(9Z,12Z))MetaboliteLMFA07050343 (LIPID MAPS)
CoA(18:3(6Z,9Z,12Z))MetaboliteLMFA07050322 (LIPID MAPS)
CoA(20:3(8Z,11Z,14Z))MetaboliteLMFA07050278 (LIPID MAPS)
Cytokine StormPathway
Cytosolic Phospholipase A2 (cPLA2)GeneProduct3.1.1.4 (BRENDA)
ELOVL2GeneProductENSG00000197977 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54326
ELOVL5GeneProductENSG00000012660 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68801
FADS1GeneProductENSG00000149485 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76267
FADS2ProteinO95864 (Uniprot-TrEMBL)
GlycerophospholipidsMetaboliteCHEBI:37739 (ChEBI)
Immune reponse to SARS-COV-2PathwayWP5039 (WikiPathways)
Linoleoyl-CoA

desaturase

GeneProduct1.14.19.3 (BRENDA)
LysPE 16:0Metabolite
LysoPC16:0MetaboliteLMGP01050113 (LIPID MAPS)
Omega-3/Omega-6 FA synthesisPathwayWP4723 (WikiPathways)
Omega-3MetaboliteLMFA01030818 (LIPID MAPS)
Omega-6MetaboliteLMGP01050137 (LIPID MAPS)
SARS-CoV-2 RNARnaQ82069695 (Wikidata)
SARS-CoV-2 and

COVID-19 Pathway

Molecular mechanism
PathwayWP4846 (WikiPathways)
bishomo-gamma-linolenic acidMetaboliteLMFA01030158 (LIPID MAPS)
envelope protein EProteinP0DTC4 (Uniprot-TrEMBL)
gamma-linolenic acidMetaboliteLMFA01030141 (LIPID MAPS)
linoleic acidMetaboliteLMFA01030120 (LIPID MAPS)
membrane glycoprotein MProteinP0DTC5 (Uniprot-TrEMBL)
mitogen-activated protein kinaseGeneProduct
nucleocapsid protein NProteinP0DTC9 (Uniprot-TrEMBL)
oleic acid MetaboliteLMFA01030002 (LIPID MAPS)
palmitic acidMetaboliteLMFA01010001 (LIPID MAPS)
stearic acidMetabolite
surface glycoprotein SProteinP0DTC2 (Uniprot-TrEMBL)
trimerComplexCPX-5682 (Complex Portal)

Annotated Interactions

No annotated interactions

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