Linoleic acid metabolism known to be affected by coronavirus infection (Homo sapiens)

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1Linoleoyl-CoAdesaturaseLysPE 16:0linoleic acidLysoPC16:0bishomo-gamma-linolenic acidCytosolic Phospholipase A2oleic acidArachidonic acidpalmitic acidGlycerophospholipidsgamma-linolenic acid


Description

Lipid metabolism alternations that are related to infection by corona viruses. The information comes from the Yan et al. in 2019 in the bibliography, particularly Figure 5. That paper uses the HCoV-229E virus as a model. Note that that is different from the virus that causes the 2020 pandemic SARS-CoV-2. Fig 5 is in turn taken from https://www.kegg.jp/kegg-bin/show_pathway?map00591, which is a very simplified pathway, omitting several steps The paper mentions that after virus infection many of the metabolites in his figure are increased in concentration. Interestingly, exogenous supplement of LA or AA in HCoV-229E-infected cells significantly suppressed HCoV-229E virus replication and this also happened in MERS-CoV.

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Ontology Terms

 

Bibliography

  1. Yan B, Chu H, Yang D, Sze KH, Lai PM, Yuan S, Shuai H, Wang Y, Kao RY, Chan JF, Yuen KY; ''Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication.''; Viruses, 2019 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
110457view08:40, 13 May 2020Mkutmonfixed unconnected lines, layout
110338view19:18, 6 May 2020EgonwMade the full membrane visible
109709view14:45, 29 March 2020FehrhartOntology Term : 'lipid metabolic pathway' added !
109708view14:44, 29 March 2020FehrhartOntology Term : 'viral infectious disease' added !
109707view14:44, 29 March 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
109602view22:38, 26 March 2020EveloModified title
109597view14:51, 26 March 2020EveloModified description
109593view11:01, 26 March 2020EveloModified description
109586view15:33, 25 March 2020EgonwAdded a ChEBI identifier
109542view20:04, 22 March 2020Conroy lipidsModified description
109538view19:50, 22 March 2020Conroy lipidschanged to dotted arrows as conversion from gamma linolenic acid onwards multistep? Not fully convinced these reactions are accurate
109535view19:54, 21 March 2020Conroy lipids
109534view19:34, 21 March 2020Conroy lipidsannotated palmitic and oleic, added reaction lines (correctly?) removed generic 'fatty acids'
109533view19:07, 21 March 2020Conroy lipidstypo
109532view19:06, 21 March 2020Conroy lipidsannotated linoleoly coa DS
109531view18:55, 21 March 2020Conroy lipidsnonascii to 'gamma'
109530view18:46, 21 March 2020Conroy lipidsAdded lipidmaps IDs, EC numbers, moved cPLAs to geneproduct
109503view12:02, 20 March 2020EgonwModified description
109502view12:00, 20 March 2020EgonwAdded the source article
109501view11:46, 20 March 2020EgonwNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Cytosolic Phospholipase A2GeneProduct3.1.1.4 (BRENDA)
GlycerophospholipidsMetaboliteCHEBI:37739 (ChEBI)
Linoleoyl-CoA

desaturase

GeneProduct1.14.19.3 (BRENDA)
LysPE 16:0Metabolite
LysoPC16:0MetaboliteLMGP01050113 (LIPID MAPS)
bishomo-gamma-linolenic acidMetaboliteLMFA01030158 (LIPID MAPS)
gamma-linolenic acidMetaboliteLMFA01030141 (LIPID MAPS)
linoleic acidMetaboliteLMFA01030120 (LIPID MAPS)
oleic acid MetaboliteLMFA01030002 (LIPID MAPS)
palmitic acidMetaboliteLMFA01010001 (LIPID MAPS)

Annotated Interactions

No annotated interactions

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