Kisspeptin/Kisspeptin Receptor System in the Ovary (Homo sapiens)

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1Gq/11 protein signallingMetaboliteIndirect conversion/interactionFollicular developmentSteroidogenesisInhibitionRafErkAKTOvarian cellOocyte maturationCatalysisPathwayConversionMekOvulationIndirect stimulationLegendStimulationRasPI3KsGene productPIP2KISS1RHRASMAPK signalling pathwayDiacylglycerolRAF1GeneMAPK3NKBPathwayKisspeptinStARPIP3NFKB1NRASCYP11A1ProgesteroneAMHFSHRGDF9PLC-betaMAP2K2Protein kinase CIP3Ca2+KRASBMP15PI3K/Akt signalling pathway3B-HSDPDK1MMP-9Beta-arrestin-1Beta-arrestin-2MetMAP2K1P450sccMAPK1


Description

The signalling pathway of the kisspeptin/kisspeptin receptor interaction in the ovary, including its effects on follicular development, oocyte maturation, ovulation, and steroidogenesis.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hu KL, Zhao H, Chang HM, Yu Y, Qiao J; ''Kisspeptin/Kisspeptin Receptor System in the Ovary.''; Front Endocrinol (Lausanne), 2017 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
109508view12:41, 20 March 2020FehrhartOntology Term : 'sex steroids signaling pathway' added !
109507view12:41, 20 March 2020FehrhartOntology Term : 'sex differentiation disease' added !
109418view21:24, 16 March 2020MCMJanssenModified description
109352view13:04, 16 March 2020L DupuisConverted interactions to graphical lines in legend
109350view13:03, 16 March 2020L DupuisOntology Term : 'signaling pathway' added !
109307view08:37, 10 March 2020MCMJanssenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
3B-HSDProteinQ9H2F3 (Uniprot-TrEMBL)
AMHGeneProductENSG00000104899 (Ensembl)
BMP15GeneProductENSG00000130385 (Ensembl)
Beta-arrestin-1ProteinP49407 (Uniprot-TrEMBL)
Beta-arrestin-2ProteinK7ENA6 (Uniprot-TrEMBL)
CYP11A1GeneProductENSG00000140459 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
DiacylglycerolMetaboliteCHEBI:4481 (ChEBI)
FSHRGeneProductENSG00000170820 (Ensembl)
GDF9GeneProductENSG00000164404 (Ensembl)
GeneGeneProduct
HRASGeneProductENSG00000174775 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
KISS1RGeneProductENSG00000116014 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
KisspeptinMetaboliteCHEBI:80304 (ChEBI)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK signalling pathwayPathwayWP382 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MMP-9ProteinP14780 (Uniprot-TrEMBL)
MetMetabolite
NFKB1GeneProductENSG00000109320 (Ensembl)
NKBMetaboliteQ412604 (Wikidata)
NRASGeneProductENSG00000213281 (Ensembl)
P450sccProteinE7EPP8 (Uniprot-TrEMBL)
PDK1GeneProductENSG00000152256 (Ensembl)
PI3K/Akt signalling pathwayPathwayWP4172 (WikiPathways)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLC-betaProteinA0A087WT80 (Uniprot-TrEMBL)
PathwayPathway
ProgesteroneMetaboliteCHEBI:8453 (ChEBI)
Protein kinase CProteinA0A087X0I9 (Uniprot-TrEMBL)
RAF1GeneProductENSG00000132155 (Ensembl)
StARGeneProductENSG00000147465 (Ensembl)

Annotated Interactions

No annotated interactions

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