GDNF/RET signalling axis (Homo sapiens)

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1RepulsionMetanephric mesenchymeMaintenanceNephrogenic cordNephric ductRETGFRA1SPRY1FOXC1SOX17EYA1SOX11PAX2SALL1AGTR2FOXC2GDNFGATA3FAT4ROBO2GLI3BMP4IFT27HSPB11LHX1SLIT2CTNNB1GREM1GDNF


Description

GDNF-RET signalling is at the core of the signalling network in kidney development. These signalling interactions between the metanephric mesenchyme and the nephric duct are crucial to ensure the induction of the ureter from the nephric duct.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4820_109222.gpml] with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Kozlov VM, Schedl A; ''Duplex kidney formation: developmental mechanisms and genetic predisposition.''; F1000Res, 2020 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
109223view07:59, 28 February 2020FehrhartNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AGTR2GeneProductENSG00000180772 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000068122
BMP4GeneProductENSG00000125378 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021835
CTNNB1ProteinENSG00000168036 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q02248
EYA1GeneProductENSG00000104313 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025932
FAT4GeneProductENSG00000196159 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046743
FOXC1GeneProductENSG00000054598 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000050295
FOXC2GeneProductENSG00000176692 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046714
GATA3GeneProductENSG00000107485 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015619
GDNFGeneProductENSG00000168621 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022144
GFRA1ProteinENSG00000151892 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P97785
GLI3ProteinENSG00000106571 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q61602
GREM1GeneProductENSG00000166923 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000074934
HSPB11ProteinENSG00000081870 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9D6H2
IFT27ProteinENSG00000100360 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9D0P8
LHX1GeneProductENSG00000273706 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018698
PAX2GeneProductENSG00000075891 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004231
RETProteinENSG00000165731 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P35546
ROBO2GeneProductENSG00000185008 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052516
SALL1GeneProductENSG00000103449 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031665
SLIT2GeneProductENSG00000145147 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031558
SOX11GeneProductENSG00000176887 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063632
SOX17GeneProductENSG00000164736 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025902
SPRY1GeneProductENSG00000164056 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037211

Annotated Interactions

No annotated interactions
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