Mevalonate Pathway (Saccharomyces cerevisiae)

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3-hydroxy-3-methyl-glutaryl-CoAdelta3-isopentenyl-PPH2O2 NADPdimethylallyl-pyrophosphatemevalonatemevalonate-5Pmevalonate-5-PPCO2ATPERG12acetoacetyl-CoAHMG2HMG1ERG10ADPIDI1acetyl-CoAATPMVD1ADPCoenzyme A2 acetyl-CoACoenzyme ACoenzyme AphosphateADPATPERG8ARG5,62 NADPH


Pyridoxal phosphate (PLP) is the active form of vitamin B6 and is a cofactor in many reactions of amino acid metabolism. Pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) are all forms of vitamin B6 that can be converted to PLP via the PLP salvage pathway. Most unicellular organisms and plants can synthesize PLP, whereas mammals cannot and require vitamin B6 in their diet. Thus far, three PLP biosynthetic pathways have been characterized: the de novo PLP biosynthesis pathway as characterized in Escherichia coli (CITS: [12686115]), the de novo PLP biosynthesis pathway as being studied in fungi (CITS: [15483325],[14764090]), and the PLP salvage pathway (CITS: [15483325], [17696614],[8764513],[9537380]). Saccharomyces cerevisiae synthesize PLP via the fungal type de novo PLP synthesis pathway and the PLP salvage pathway (CITS: [7896706], [17696614], [15483325], [14764090]). Extracellular PN, PL and PM are transported into the cell by Tpn1p, a member of the purine-cytosine permease family (CITS: [12649274]). SOURCE: SGD pathways,


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90087view07:20, 13 October 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
87834view11:45, 25 July 2016ElisaOntology Term : 'classic metabolic pathway' added !
69884view18:34, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69630view20:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
41865view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
36628view22:34, 9 April 2010MaintBotDescription and bibliography added from SGD
21696view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Mevalonate Pathway]] moved to [[Pathway:WP483]]: Moved to stable identifier
12784view08:02, 17 May 2008MaintBotautomated metabolite conversion
8831view14:10, 7 January 2008MaintBotAdded to category $category
8829view14:10, 7 January 2008M.BraymerUploaded new pathway

External references


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NameTypeDatabase referenceComment
2 NADPHMetabolite53-57-6 (CAS)
2 acetyl-CoAMetabolite72-89-9 (CAS)
ADPMetabolite58-64-0 (CAS)
ARG5,6GeneProductS000000871 (SGD)
ATPMetabolite1927-31-7 (CAS)
Coenzyme AMetabolite64885-97-8 (CAS)
ERG10GeneProductS000005949 (SGD)
ERG12GeneProductS000004821 (SGD)
ERG8GeneProductS000004833 (SGD)
HMG1GeneProductS000004540 (SGD)
HMG2GeneProductS000004442 (SGD)
IDI1GeneProductS000006038 (SGD)
MVD1GeneProductS000005326 (SGD)
acetoacetyl-CoAMetabolite1420-36-6 (CAS)
acetyl-CoAMetabolite72-89-9 (CAS)
phosphateMetabolite14265-44-2 (CAS)

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