Genes controlling renal nephrogenesis (Homo sapiens)

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1Ureteric bud induction and condensationPretubular aggregationMature glomerulusCapillaryloopS-shapeNephrogenesisComma-shapeEYA1ITGB1ITGA3LMX1BGDNFCXCR4SIX1FOXD1PDGFBHOXA11CXCL12VEGFAKIRREL1LAMB2KDRWT1LHX1FOXC2NCK1ITGA8NPHS2NPHS1FGF8RETCD2APWNT4ROBO2NCK2ITGB1FOXC1NOTCH2TCF21PDGFRBPAX2CD36SLIT2EMX2FGFR2HOXD11


Description

Kidneys develop from intermediate mesoderm under the timed or sequential control of a growing number of genes. These genes have been identified at various stages of glomerulotubular development in the mammalian kidney. The genes listed have been tested in various genetically modified mice, and their location corresponds to the classical stages of kidney development postulated by Saxen in 1987.

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Ontology Terms

 

Bibliography

  1. George, Jr. AL, Neilson EG.; ''Genes controlling renal nephrogenesis''; Harrison's Principles of Internal Medicine,

History

CompareRevisionActionTimeUserComment
109268view09:10, 3 March 2020Fehrhartupdate
109163view13:53, 21 February 2020Iulia.ioncuOntology Term : 'signaling pathway' added !
109153view17:58, 18 February 2020Iulia.ioncuModified description
109152view16:39, 18 February 2020Iulia.ioncuNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CD2APGeneProductENSG00000198087 (Ensembl)
CD36GeneProductENSG00000135218 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
EMX2GeneProductENSG00000170370 (Ensembl)
EYA1GeneProductENSG00000104313 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FOXC1GeneProductENSG00000054598 (Ensembl)
FOXC2GeneProductENSG00000176692 (Ensembl)
FOXD1GeneProductENSG00000251493 (Ensembl)
GDNFGeneProductENSG00000168621 (Ensembl)
HOXA11GeneProductENSG00000005073 (Ensembl)
HOXD11GeneProductENSG00000128713 (Ensembl)
ITGA3GeneProductENSG00000005884 (Ensembl)
ITGA8GeneProductENSG00000077943 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
KDRGeneProductENSG00000128052 (Ensembl)
KIRREL1GeneProductENSG00000183853 (Ensembl)
LAMB2GeneProductENSG00000172037 (Ensembl)
LHX1GeneProductENSG00000273706 (Ensembl)
LMX1BGeneProductENSG00000136944 (Ensembl)
NCK1GeneProductENSG00000158092 (Ensembl)
NCK2GeneProductENSG00000071051 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
NPHS1GeneProductENSG00000161270 (Ensembl)
NPHS2GeneProductENSG00000116218 (Ensembl)
PAX2GeneProductENSG00000075891 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
RETGeneProductENSG00000165731 (Ensembl)
ROBO2GeneProductENSG00000185008 (Ensembl)
SIX1GeneProductENSG00000126778 (Ensembl)
SLIT2GeneProductENSG00000145147 (Ensembl)
TCF21GeneProductENSG00000118526 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WT1GeneProductENSG00000184937 (Ensembl)

Annotated Interactions

No annotated interactions

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