Conversion of angiotensinogen to angiotensin II (Homo sapiens)

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1NRAS pathwayRAS pathwayCMA1AngiotensinogenCTSGACEhuman angiotensin IICTSGCTSDAngiotensin IREN


This pathway depicts the conversion of Angiotensinogen to Angiotensin II by enzymes of the Renin-Angiotensin-System (RAS) and Nonrenin-Angiotensin-System (NRAS). The NRAS pathway includes both direct and indirect conversion.

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Ontology Terms



  1. Karlsson C, Lindell K, Ottosson M, Sjöström L, Carlsson B, Carlsson LM; ''Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II.''; J Clin Endocrinol Metab, 1998 PubMed Europe PMC Scholia


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117691view12:12, 22 May 2021EweitzModified title
110062view07:11, 16 April 2020FehrhartOntology Term : 'angiotensin II signaling pathway' added !
109267view08:37, 3 March 2020Fehrhartupdate
109140view12:13, 18 February 2020LVreeswijkModified description
109139view12:11, 18 February 2020LVreeswijkOntology Term : 'classic metabolic pathway' added !
109138view12:04, 18 February 2020LVreeswijkNew pathway

External references


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NameTypeDatabase referenceComment
ACEGeneProductENSG00000159640 (Ensembl)
Angiotensin IMetaboliteCHEBI:2718 (ChEBI)
AngiotensinogenMetaboliteCHEBI:2720 (ChEBI)
CMA1ProteinP23946 (Uniprot-TrEMBL)
CTSD ProteinA0A1B0GV23 (Uniprot-TrEMBL)
CTSGProteinP08311 (Uniprot-TrEMBL)
RENProteinA0A1B0GUZ2 (Uniprot-TrEMBL)
human angiotensin IIMetaboliteCHEBI:2719 (ChEBI)

Annotated Interactions

No annotated interactions

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