Insulin Signaling (Homo sapiens)

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Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.

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Ontology Terms



  1. Quon MJ, Campfield LA; ''A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation.''; J Theor Biol, 1991 PubMed
  2. Saltiel AR, Kahn CR; ''Insulin signalling and the regulation of glucose and lipid metabolism.''; Nature, 2001 PubMed
  3. Bevan P; ''Insulin signalling.''; J Cell Sci, 2001 PubMed


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94171view07:53, 25 August 2017MkutmonReverted to version '21:20, 21 October 2016' by Mkutmon
94128view18:11, 22 August 2017Ycc86829Quick edit to datanode annotation or property
90197view21:20, 21 October 2016Khanspersfixed unconnected
89370view21:48, 9 September 2016AlexanderPicoremoved extra complex groupings and updated cell membrane
82731view00:20, 24 October 2015Andra
82730view00:19, 24 October 2015Andramoved hidden data nodes to make them visible
82729view22:07, 23 October 2015AndraChanged the layout
72080view20:45, 24 October 2013AlexanderPicoremoved IRS3, which does not have a human homolog
71379view18:39, 17 October 2013MaintBotAutomated update of data sources
63219view21:01, 8 May 2013MaintBotUpdating gpml version
59178view18:44, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45380view21:46, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45185view09:32, 7 October 2011Eduatiadded reference
45184view09:28, 7 October 2011Eduatitypo
45183view09:27, 7 October 2011EduatiIndicate complex formation
45179view09:06, 7 October 2011EduatiModified description
44854view09:52, 6 October 2011MartijnVanIerselOntology Term : 'insulin signaling pathway' added !
44853view09:51, 6 October 2011MartijnVanIerselOntology Term : 'PW:0000034' removed !
44835view08:03, 6 October 2011Mkutmonconnected some lines
42706view21:56, 15 April 2011Khanspersminor layout change
41137view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38887view19:05, 24 September 2010Khanspers
33660view12:22, 2 December 2009AndraSpecify description
33659view12:04, 2 December 2009AndraAdded Geneproduct plus reference
33027view15:23, 5 October 2009AndraSpecify description
33026view15:23, 5 October 2009AndraSpecify description
32444view17:19, 15 August 2009MaintBotFixed text labels
32118view13:51, 14 August 2009MaintBotFixed group labels
28132view19:46, 27 January 2009KhanspersRemoved species code from name
21692view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Insulin Signaling]] moved to [[Pathway:WP481]]: Moved to stable identifier
15807view08:31, 4 June 2008AndraAdd a reference
13887view13:18, 19 May 2008Thomasgrouped datanodes and connected lines
12946view10:43, 17 May 2008MaintBotSticky edges patch by Sjoerd
8212view13:46, 7 January 2008MaintBot[[Pathway:Human:Insulin Signaling]] moved to [[Pathway:Homo sapiens:Insulin Signaling]]: Renaming species
7726view16:13, 18 December 2007MaintBotfixed category names
7265view12:41, 4 November 2007MaintBotAdded categories to GPML
6344view22:18, 22 May 2007M.Pattigpml file for [[Human:Insulin_Signaling]]

External references


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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
APSGeneProduct10603 (Entrez Gene)
ARF1GeneProduct375 (Entrez Gene)
ARF6GeneProduct382 (Entrez Gene)
CAP1GeneProduct10487 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CBLCGeneProduct23624 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
EGR1GeneProduct1958 (Entrez Gene)
EHD1GeneProduct10938 (Entrez Gene)
EHD2GeneProduct30846 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
ENPP1GeneProduct5167 (Entrez Gene)
FLOT1GeneProduct10211 (Entrez Gene)
FLOT2GeneProduct2319 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
FRAP1GeneProduct2475 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GRB10GeneProduct2887 (Entrez Gene)
GRB14GeneProduct2888 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
GYGGeneProduct2992 (Entrez Gene)
GYS1GeneProduct2997 (Entrez Gene)
GYS2GeneProduct2998 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IGF1RGeneProduct3480 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
INPP4AGeneProduct3631 (Entrez Gene)
INPPL1GeneProduct3636 (Entrez Gene)
INSRGeneProduct3643 (Entrez Gene)
IRS1/2GeneProduct3667 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
IRS4GeneProduct8471 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
KIF3AGeneProduct11127 (Entrez Gene)
KIF5BGeneProduct3799 (Entrez Gene)
LIPEGeneProduct3991 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K10GeneProduct4294 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K2GeneProduct10746 (Entrez Gene)
MAP3K3GeneProduct4215 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP3K9GeneProduct4293 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K2GeneProduct5871 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene)
MAP4K4GeneProduct9448 (Entrez Gene)
MAP4K5GeneProduct11183 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
MYO1CGeneProduct4641 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PFKLGeneProduct5211 (Entrez Gene)
PFKMGeneProduct5213 (Entrez Gene)
PIK3C2AGeneProduct5286 (Entrez Gene)
PIK3C2GGeneProduct5288 (Entrez Gene)
PIK3C3GeneProduct5289 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3GeneProductENSG00000121879 (Ensembl)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PIK3R4GeneProduct30849 (Entrez Gene)
PPP1R3AGeneProduct5506 (Entrez Gene)
PRKAA1GeneProduct5562 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCHGeneProduct5583 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PSCD3GeneProduct9265 (Entrez Gene)
PTENGeneProduct5728 (Entrez Gene)
PTPGeneProduct5967 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN1GeneProduct5770 (Entrez Gene)
PTPRFGeneProduct5792 (Entrez Gene)
RAB4AGeneProduct5867 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RHEBGeneProduct6009 (Entrez Gene)
RHOJGeneProduct57381 (Entrez Gene)
RHOQGeneProduct23433 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
RPS6KA4GeneProduct8986 (Entrez Gene)
RPS6KA5GeneProduct9252 (Entrez Gene)
RPS6KA6GeneProduct27330 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
RRADGeneProduct6236 (Entrez Gene)
SGK2GeneProduct10110 (Entrez Gene)
SGKGeneProduct6446 (Entrez Gene)
SGKLGeneProduct23678 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SHC2GeneProduct25759 (Entrez Gene)
SHC3GeneProduct53358 (Entrez Gene)
SLC2A1GeneProduct6513 (Entrez Gene)
SLC2A4GeneProduct6517 (Entrez Gene)
SNAP23GeneProduct8773 (Entrez Gene)
SNAP25GeneProduct6616 (Entrez Gene)
SNX26GeneProduct115703 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SORBS1GeneProduct10580 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene)
SRFGeneProduct6722 (Entrez Gene)
STX4AGeneProduct6810 (Entrez Gene)
STXBP1GeneProduct6812 (Entrez Gene)
STXBP2GeneProduct6813 (Entrez Gene)
STXBP3GeneProduct6814 (Entrez Gene)
STXBP4GeneProduct252983 (Entrez Gene)
TBC1D4GeneProduct9882 (Entrez Gene)
TRIB3GeneProduct57761 (Entrez Gene)
TSC1GeneProduct7248 (Entrez Gene)
TSC2GeneProduct7249 (Entrez Gene)
VAMP2GeneProduct6844 (Entrez Gene)
XBP1GeneProduct7494 (Entrez Gene)

Annotated Interactions

No annotated interactions

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