Purine metabolism (Homo sapiens)

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128 steps involveddGTPXanthosineFAICARPInosineADSLSAICARPATICAdenosineRibose-5-PAICARPSuccinyladenosineATPGMPAMPAPRTITPGDPHPRT1UrateHypoxanthinePRPS1ADAPRPPPRPPsS-AMPdATPAMPD1dGDP2,8-DihydroxyadenineDGUOKGuanineADSSITPAGuanosineSAICA-ribosideGTPXanthineAdenineRRADP2-DeoxyguanosinedAMPdGMPIMPDH1XMPPNP2'-DeoxyadenosinedADPADSLAICA-riboside2'-deoxyinosineIMPPNPPNPXORRATICADAPNPHPRT1XOPNPXOPNP


Description

Overview of purine metabolism; metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels.

This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). The full version of this PW including disorders, based on ed. 4, can be found here.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Blau, N., Duran, M., Gibson, K.M., Dionisi-Vici, C.; '''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 11'''; ISBN 978-3-642-40337-8,, 2014
  2. Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014

History

View all...
CompareRevisionActionTimeUserComment
109348view12:57, 16 March 2020L DupuisConnected one unconnected line
109308view08:42, 10 March 2020DeSlOntology Term : 'DOID:5810' removed !
109256view15:18, 2 March 2020Mkutmonfixed unconnected lines
109224view09:43, 28 February 2020Mkutmonlayout adaption
108876view08:44, 4 February 2020DeSlModified description
108875view08:43, 4 February 2020DeSlModified description
108874view08:42, 4 February 2020DeSlOntology Term : 'DOID:0080121' removed !
108873view08:41, 4 February 2020DeSlOntology Term : 'PW:0001779' removed !
108870view15:12, 3 February 2020DeSlOntology Term : 'DOID:1919' removed !
108869view15:12, 3 February 2020DeSlOntology Term : 'PW:0001592' removed !
108868view15:12, 3 February 2020DeSlOntology Term : 'DOID:0060350' removed !
108867view15:10, 3 February 2020DeSlOntology Term : 'PW:0001777' removed !
108866view15:09, 3 February 2020DeSlOntology Term : 'DOID:0050762' removed !
108865view15:09, 3 February 2020DeSlOntology Term : 'PW:0001879' removed !
108864view15:08, 3 February 2020DeSlOntology Term : 'PW:0001776' removed !
108863view15:08, 3 February 2020DeSlModified description
108862view15:07, 3 February 2020DeSlModified description
108861view15:05, 3 February 2020DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2'-DeoxyadenosineMetaboliteCHEBI:17256 (ChEBI)
2'-deoxyinosineMetaboliteCHEBI:28997 (ChEBI)
2,8-DihydroxyadenineMetaboliteQ4596812 (Wikidata)
2-DeoxyguanosineMetaboliteCHEBI:17172 (ChEBI)
ADAProteinP00813 (Uniprot-TrEMBL)
ADPMetaboliteCHEBI:456216 (ChEBI)
ADSLProteinP30566 (Uniprot-TrEMBL)
ADSSProteinP30520 (Uniprot-TrEMBL) Adenylosuccinate synthetase isozyme 2
AICA-ribosideMetaboliteCHEBI:28498 (ChEBI)
AICARPMetaboliteCHEBI:58475 (ChEBI)
AMPMetaboliteCHEBI:456215 (ChEBI)
AMPD1ProteinP23109 (Uniprot-TrEMBL)
APRTProteinP07741 (Uniprot-TrEMBL)
ATICProteinP31939 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:30616 (ChEBI)
AdenineMetaboliteCHEBI:16708 (ChEBI)
AdenosineMetaboliteCHEBI:16335 (ChEBI)
DGUOKProteinQ16854 (Uniprot-TrEMBL)
FAICARPMetaboliteCHEBI:58467 (ChEBI)
GDPMetaboliteCHEBI:58189 (ChEBI)
GMPMetaboliteCHEBI:58115 (ChEBI)
GTPMetaboliteCHEBI:37565 (ChEBI)
GuanineMetaboliteCHEBI:16235 (ChEBI)
GuanosineMetaboliteCHEBI:16750 (ChEBI)
HPRT1ProteinP00492 (Uniprot-TrEMBL)
HypoxanthineMetaboliteCHEBI:17368 (ChEBI)
IMPMetaboliteCHEBI:58053 (ChEBI)
IMPDH1ProteinP20839 (Uniprot-TrEMBL)
ITPAProteinQ9BY32 (Uniprot-TrEMBL)
ITPMetaboliteCHEBI:61402 (ChEBI) is a nucleoside triphosphate(4−)
InosineMetaboliteCHEBI:17596 (ChEBI)
PNPProteinP00491 (Uniprot-TrEMBL)
PRPPMetaboliteCHEBI:17111 (ChEBI)
PRPPsProtein2.7.6.1 (Enzyme Nomenclature)
PRPS1ProteinP60891 (Uniprot-TrEMBL)
RRProtein1.17.4.1 (Enzyme Nomenclature)
Ribose-5-PMetaboliteCHEBI:52742 (ChEBI)
S-AMPMetaboliteCHEBI:57567 (ChEBI) succinyladenosine monophosphate
SAICA-ribosideMetaboliteCHEBI:18319 (ChEBI)
SAICARPMetaboliteCHEBI:58443 (ChEBI)
SuccinyladenosineMetaboliteCHEBI:71169 (ChEBI)
UrateMetaboliteCHEBI:17775 (ChEBI)
XMPMetaboliteCHEBI:57464 (ChEBI)
XOProteinP47989 (Uniprot-TrEMBL)
XanthineMetaboliteCHEBI:17712 (ChEBI)
XanthosineMetaboliteCHEBI:18107 (ChEBI)
dADPMetaboliteCHEBI:57667 (ChEBI)
dAMPMetaboliteCHEBI:58245 (ChEBI)
dATPMetaboliteCHEBI:61404 (ChEBI)
dGDPMetaboliteCHEBI:58595 (ChEBI)
dGMPMetaboliteCHEBI:57673 (ChEBI)
dGTPMetaboliteCHEBI:16497 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
2'-Deoxyadenosine2'-deoxyinosinemim-conversion28191 (Rhea)
2'-DeoxyadenosineAdeninemim-conversion27743 (Rhea)
2'-deoxyinosineHypoxanthinemim-conversion27751 (Rhea)
2-DeoxyguanosineGuaninemim-conversion27739 (Rhea)
2-DeoxyguanosinedGMPmim-conversion19202 (Rhea)
ADPATPmim-conversion30657 (Rhea)
ADPdADPmim-conversion28036 (Rhea)
AICARPFAICARPmim-conversion22193 (Rhea)
AMPADPmim-conversion11462 (Rhea)
AMPAdenosinemim-conversion29376 (Rhea)
AMPIMPmim-conversion14778 (Rhea)
AdenineAMPmim-conversion16611 (Rhea)
AdenosineAdeninemim-conversion18670 (Rhea)
AdenosineInosinemim-conversion24409 (Rhea)
FAICARPIMPmim-conversion18447 (Rhea)
GDPGTPmim-conversion29865 (Rhea)
GDPdGDPmim-conversion28032 (Rhea)
GMPGDPmim-conversion20781 (Rhea)
GMPGuanosinemim-conversion27715 (Rhea)
Guaninemim-conversion14666 (Rhea)
Guaninemim-conversion25426 (Rhea)
GuanosineGuaninemim-conversion13234 (Rhea)
HypoxanthineXanthinemim-conversion24671 (Rhea)
Hypoxanthinemim-conversion17975 (Rhea)
IMPInosinemim-conversion27719 (Rhea)
IMPS-AMPmim-conversion15754 (Rhea)
IMPXMPmim-conversion11709 (Rhea)
ITPIMPmim-conversion29400 (Rhea)
InosineHypoxanthinemim-conversion16658 (Rhea)
S-AMPAMPmim-conversion16854 (Rhea)
SAICARPAICARPmim-conversion23921 (Rhea)
XMPGMPmim-conversion18302 (Rhea)
XMPXanthosinemim-conversion28531 (Rhea)
XanthineUratemim-conversion16670 (Rhea)
XanthosineXanthinemim-conversion27639 (Rhea)
dADPdAMPmim-conversion23102 (Rhea)
dADPdATPmim-conversion27675 (Rhea)
dAMP2'-Deoxyadenosinemim-conversion29372 (Rhea)
dGDPdGMPmim-conversion12699 (Rhea)
dGDPdGTPmim-conversion27691 (Rhea)
dGMP2-Deoxyguanosinemim-conversion19203 (Rhea)
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