Chorismate Biosynthesis (Saccharomyces cerevisiae)

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Chorismate, an intermediate in the synthesis of the aromatic amino acids and the vitamins, p-aminobenzoate and p-hydroxybenzoate, is synthesized by the shikimate pathway. The shikimate pathway has been found to be common to all eukaryotes and prokaryotes studied thus far (as reported in (CITS:[1943992])). In Saccharomyces cerevisiae the initial step is catalyzed by two deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase isoenzymes, one of which (ARO3) is feedback inhibited by phenylalanine, and the other (ARO4) by tyrosine (CITS:[1943992]). Both DAHP isoenzymes are derepressed by amino acid starvation (general control of amino acid biosynthesis) (CITS:[2906401]). The 5 subsequent reactions are catalyzed by the pentafunctional arom enzyme, Aro1p (CITS:[1943992][2825635]). Aro1p is a mosaic of five monofunctional domains, each of which corresponds to one of five separate monofunctional E. coli enzymes (CITS:[1943992][2825635]). The last step of chorismate biosynthesis, before the pathway branches to synthesize different terminal products, is catalyzed by Aro2p (CITS:[Jones][1943992]).

SOURCE: SGD pathways,

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  1. Braus GH; ''Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.''; Microbiol Rev, 1991 PubMed Europe PMC


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107263view14:35, 17 September 2019MaintBotChEBI identifier normalization
92978view17:43, 21 July 2017KhanspersModified description
92977view17:43, 21 July 2017Khanspersremoved GenMAPP notes
92917view10:52, 17 July 2017DeSlChanged CAs to ChEBI ID (more stereospecific).
89660view05:03, 24 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
73732view20:00, 19 February 2014EgonwFixed the PubChem-compound DB name.
73731view19:57, 19 February 2014EgonwFigured out the EPSP identifier too.
73730view19:47, 19 February 2014EgonwAdded two more missing metabolite IDs.
73729view19:42, 19 February 2014EgonwAdded a bunch of missing metabolite identifiers.
71337view18:00, 17 October 2013MaintBotAutomated update of data sources
71020view19:59, 22 September 2013EgonwConverted many labels into Metabolite DataNodes.
69883view18:33, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69575view20:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
67778view15:04, 26 June 2013DdiglesOntology Term : 'shikimate metabolic pathway' added !
41795view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
36615view22:31, 9 April 2010MaintBotDescription and bibliography added from SGD
21688view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Chorismate Biosynthesis]] moved to [[Pathway:WP479]]: Moved to stable identifier
12672view07:57, 17 May 2008MaintBotautomated metabolite conversion
8666view14:06, 7 January 2008MaintBotAdded to category $category
8664view14:06, 7 January 2008J.HeckmanUploaded new pathway

External references


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NameTypeDatabase referenceComment
3-dehydro-shikimateMetaboliteCHEBI:16630 (ChEBI)
3-dehydroquinateMetaboliteCHEBI:32364 (ChEBI)
3-deoxy-arabino-heptulosonate-7-phosphateMetabolite5460215 (PubChem-compound)
5-enolypyruvylshikimate-3-phosphateMetaboliteCHEBI:57701 (ChEBI)
ADPMetabolite58-64-0 (CAS)
ARO1GeneProductS000002534 (SGD)
ARO2GeneProductS000003116 (SGD)
ARO3GeneProductS000002442 (SGD)
ARO4GeneProductS000000453 (SGD)
ATPMetabolite1927-31-7 (CAS)
H2OMetaboliteCHEBI:15377 (ChEBI)
NADPMetaboliteCHEBI:18009 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
chorismateMetaboliteCHEBI:17333 (ChEBI)
erythrose-4-phosphateMetabolite585-18-2 (CAS)
phosphateMetabolite14265-44-2 (CAS)
phosphateMetaboliteCHEBI:26020 (ChEBI)
phosphoenolpyruvateMetabolite138-08-9 (CAS)
shikimate-3-phosphateMetaboliteCHEBI:57701 (ChEBI)
shikimateMetaboliteCHEBI:36208 (ChEBI)

Annotated Interactions

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