1, 2Model human liver cell showing blood, bile and intestinal compartments, indicating tissueinvolvment of genes in the irinotecan pathway.IntestineDiarrheaLiver CellNeutropeniaGm5744Gm5744BcheCes3ApcCes3CYP3A5Abcc1NPC1IrinotecanCes3SN-38Ugt1a6SN-38CYP3A4SN-38Abcc2Ces3CYP3A4SN-38GAbcc2Ugt1a10Ugt1a9Abcc1IrinotecanCYP3A4Gm5744CYP3A5Abcg2Abcc2Ugt1a1Ugt1a1Gm5744IrinotecanSN-38GUgt1a6Abcc1M4