Renin Angiotensin Aldosterone System (RAAS) (Homo sapiens)

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266CorticosteroneCALML3CALML518-hydroxycorticosteroneCholesterolCYP11B2CALML6ACEProgesteroneCAMK1DPregnenoloneITPR1HSD3B2CALM3PLCB211-DeoxycorticosteroneACE InhibitorGNAQCALM1calciumAGTR1 InhibitorCTSGRENCALM2STARHSD3B1AGTATF6BCYP21A2CYP11A1Angiotensin IIIP3CMA1ITPR2Angiotensin IITPR3CALML432AGTR26AGTR1Aldosterone4Molecular initiating events22CAMK1GCAMK4CAMK2ACAMK2BCAMK2DCAMK2GCAMK1ATF2ATF1CREB5CREB3L4CREB3L3CREB3L2CREB3L1CREB3CREB1ATF4


Description

The pathway leading angiotensinogen to aldosterone

Quality Tags

Ontology Terms

 

Bibliography

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  1. McDowell SE, Coleman JJ, Ferner RE; ''Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.''; BMJ, 2006 PubMed Europe PMC
  2. Williams GH; ''Aldosterone biosynthesis, regulation, andclassical mechanism of action.''; Heart Fail Rev, 2005 PubMed Europe PMC
  3. Schwartz GL, Turner ST; ''Pharmacogenetics of antihypertensive drug responses.''; Am J Pharmacogenomics, 2004 PubMed Europe PMC
  4. Bassett MH, White PC, Rainey WE; ''The regulation of aldosterone synthase expression.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC
  5. Athyros VG, Mikhailidis DP, Kakafika AI, Tziomalos K, Karagiannis A; ''Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?''; Expert Opin Pharmacother, 2007 PubMed Europe PMC
  6. Weir MR; ''Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?''; Clin Ther, 2007 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
108364view19:52, 12 December 2019OzanozisikAGTR1 Inhibitor contained ACE Inhibitor information, deleted that.
108230view20:47, 29 November 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
108227view13:29, 29 November 2019OzanozisikModified description
108226view13:28, 29 November 2019Marvin M2Ontology Term : 'renin-angiotensin cascade pathway' added !
108225view13:28, 29 November 2019Marvin M2Ontology Term : 'aldosterone biosynthetic pathway' added !
108223view13:24, 29 November 2019OzanozisikNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
11-DeoxycorticosteroneMetaboliteCHEBI:16973 (ChEBI)
18-hydroxycorticosteroneMetaboliteCHEBI:16485 (ChEBI)
ACE InhibitorMetaboliteCHEBI:35457 (ChEBI)
ACEGeneProduct1636 (Entrez Gene)
AGTGeneProduct183 (Entrez Gene)
AGTR1 InhibitorMetabolite
AGTR1GeneProduct185 (Entrez Gene)
AGTR2GeneProduct186 (Entrez Gene)
ATF1GeneProductATF1 (HGNC)
ATF2GeneProductATF2 (HGNC)
ATF4GeneProductATF4 (HGNC)
ATF6BGeneProductATF6B (HGNC)
AldosteroneMetaboliteHMDB0000037 (HMDB)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
CALM1GeneProductCALM1 (HGNC)
CALM2GeneProductCALM2 (HGNC)
CALM3GeneProductCALM3 (HGNC)
CALML3GeneProductCALML3 (HGNC)
CALML4GeneProductCALML4 (HGNC)
CALML5GeneProductCALML5 (HGNC)
CALML6GeneProductCALML6 (HGNC)
CAMK1GeneProductCAMK1 (HGNC)
CAMK1DGeneProductCAMK1D (HGNC)
CAMK1GGeneProductCAMK1G (HGNC)
CAMK2AGeneProductCAMK2A (HGNC)
CAMK2BGeneProductCAMK2B (HGNC)
CAMK2DGeneProductCAMK2D (HGNC)
CAMK2GGeneProductCAMK2G (HGNC)
CAMK4GeneProductCAMK4 (HGNC)
CMA1GeneProduct1215 (Entrez Gene)
CREB1GeneProductCREB1 (HGNC)
CREB3GeneProductCREB3 (HGNC)
CREB3L1GeneProductCREB3L1 (HGNC)
CREB3L2GeneProductCREB3L2 (HGNC)
CREB3L3GeneProductCREB3L3 (HGNC)
CREB3L4GeneProductCREB3L4 (HGNC)
CREB5GeneProductCREB5 (HGNC)
CTSGGeneProduct1511 (Entrez Gene)
CYP11A1GeneProductCYP11A1 (HGNC)
CYP11B2GeneProductCYP11B2 (HGNC)
CYP21A2GeneProductCYP21A2 (HGNC)
CholesterolMetaboliteCHEBI:16113 (ChEBI)
CorticosteroneMetaboliteCHEBI:16827 (ChEBI)
GNAQGeneProductGNAQ (HGNC)
HSD3B1GeneProductHSD3B1 (HGNC)
HSD3B2GeneProductHSD3B2 (HGNC)
IP3MetaboliteCHEBI:16595 (ChEBI)
ITPR1GeneProductITPR1 (HGNC)
ITPR2GeneProductITPR2 (HGNC)
ITPR3GeneProductITPR3 (HGNC)
PLCB2GeneProductPLCB2 (HGNC)
PregnenoloneMetaboliteCHEBI:16581 (ChEBI)
ProgesteroneMetaboliteCHEBI:17026 (ChEBI)
RENGeneProduct5972 (Entrez Gene)
STARProteinSTAR (HGNC)
calciumMetaboliteCHEBI:22984 (ChEBI)

Annotated Interactions

No annotated interactions

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