Netrin-UNC5B signaling Pathway (Homo sapiens)

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Netrins1-30Netrin-UNC5B signalingPancreatic ductal adenocarcinomatumorigenesisCYNUProteinmRNALigandAuto catalysisTranslocationRegulation of gene expressionLeads to through unknown mechanismInduced catalysisProtein-protein interactionLEGENDPhosphorylationProteinNucleusCytoplasmCYNUInduced activationProteinReceptorInhibitionNTN1NTN3NTN4DAPK1S308PPP1CANEO1ARHGEF12RGMAPDCSTAMPPRKCAPPP2R1BSRCPCIP2APAGAP2YFYNS472PYAP1INPP5DS397S127PLEKHH1PTPN11AKT1S473JUNS73PTK2BGSK3BTP53PIK3CARAC1RHOAUNC5BITGB4RGMANEO1IL6CCL2PTK2Y576Y397RAF1PMAP2K1Y222Y218MAP2K2Y226T394Y222DephosphorylationMAPK1MAPK3PT185Y187T202PY204JUNNOSNOPPP2CAY307PPP2CAPromotes adhesion in vascular smooth muscle cellsCTGFChondrocyte proliferation, differentiation and cell adhesionPTPATumor supressorARHGEF12OsteoclastdifferentiationOsteoclastdifferentiationOsteoclastdifferentiationInflammation, B-cell maturationChemotactic activity in monocytes and basophilsTNFRegulation of cell proliferation and differentiationIL1AImmune responses,inflammationand hematopoiesis IL10B cell survivaland proliferation COL1AOsteogenic differentiationALPLBone mineralizationICAM1Cell adhesionVCAM1Leukocyte-endothelial cell adhesionSELECell adhesionMAPK14PCASP3YAP1CYNUNucleusUNC5BPUNC5BROBO4KDRY951CytoplasmPlasma membraneCDH529


Description

UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. It can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, where it promotes cell death in the absence of its ligand netrin-1 and increases cell survival in its presence. In addition, inhibition of the ligand has been reported to decrease invasiveness and angiogenesis in tumors. UNC5B signaling pathway has also been reported to be involved in several processes such as neural development, developmental angiogenesis and inflammatory processes. Interaction of UNC5B with netrins activates various signaling modules including ERK1/ERK2, p38 MAPK signaling and PI3k-AKT pathway modules

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Bibliography

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History

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CompareRevisionActionTimeUserComment
108877view09:48, 4 February 2020DeSlChanged /ncbigene/5524 to correct format.
108362view14:52, 12 December 2019Marvin M2Connected line
108259view14:38, 3 December 2019L DupuisConcerted interactions to graphical lines in the legend
108141view10:33, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
107976view13:48, 18 November 2019Subbannayyaupdated gene symbols
107970view09:57, 18 November 2019SubbannayyaOntology Term : 'cancer' added !
107969view09:55, 18 November 2019SubbannayyaModified description
107968view09:52, 18 November 2019SubbannayyaNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AGAP2GeneProduct116986 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ALPLGeneProduct249 (Entrez Gene)
ARHGEF12GeneProduct23365 (Entrez Gene)
B cell survival and proliferation Pathway
Bone mineralizationPathway
CASP3GeneProduct836 (Entrez Gene)
CCL2GeneProduct6347 (Entrez Gene)
CDH5GeneProduct1003 (Entrez Gene)
CIP2AGeneProduct57650 (Entrez Gene)
COL1AGeneProduct1277 (Entrez Gene)
CTGF GeneProduct1490 (Entrez Gene)
Cell adhesionPathway
Chemotactic activity in monocytes and basophilsPathway
Chondrocyte proliferation,

differentiation and

cell adhesion
Pathway
DAPK1GeneProduct1612 (Entrez Gene)
DCSTAMPGeneProduct81501 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GSK3BGeneProduct4617 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
IL10GeneProduct3586 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL6GeneProduct6018 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
ITGB4GeneProduct3691 (Entrez Gene)
Immune responses,

inflammation

and hematopoiesis
Pathway
Inflammation, B-cell maturationPathway
JUN GeneProduct3725 (Entrez Gene)
KDRGeneProduct3791 (Entrez Gene)
Leukocyte-endothelial cell adhesionPathway
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
NEO1GeneProduct4756 (Entrez Gene)
NOPathway
NOSPathway
NTN1GeneProduct9423 (Entrez Gene)
NTN3GeneProduct4917 (Entrez Gene)
NTN4GeneProduct59277 (Entrez Gene)
Osteoclast differentiationPathway
Osteogenic differentiationPathway
PIK3CAGeneProduct5290 (Entrez Gene)
PLEKHH1GeneProduct57475 (Entrez Gene)
PPP1CAGeneProduct5499 (Entrez Gene)
PPP2CAGeneProduct5499 (Entrez Gene)
PPP2R1BGeneProduct5519 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTPA GeneProduct5524 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
Pancreatic ductal
adenocarcinoma
tumorigenesis
Pathway
Promotes adhesion
in vascular smooth
muscle cells
Pathway
ProteinProtein5894 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RGMAGeneProduct56963 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
ROBO4GeneProduct54538 (Entrez Gene)
Regulation of

cell proliferation

and differentiation
Pathway
SELEGeneProduct6401 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
Tumor supressorPathway
UNC5B GeneProduct219699 (Entrez Gene)
UNC5BGeneProduct219699 (Entrez Gene)
VCAM1GeneProduct7412 (Entrez Gene)
YAP1GeneProduct10413 (Entrez Gene)

Annotated Interactions

No annotated interactions

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