Sphingolipid Metabolism (general overview) (Homo sapiens)

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12N-acyl chains:ASAH1UGCGSGMS1SGPP1HexadecanalSphingosineDEGS1SPTLC1Ppap2aEthanolamine-phosphatePalmitoyl-CoACERKSPHK2SPHK1KDSR3-keto-sphinganineSerineATPH2OSGPL1SPTLC233Sphinganine33Sphinganine-1-phosphateDH-Ceramide3CERS4CERS4CERS6CeramideCer-1-P3DH-Cer-1-PSMGlc-CerDH-SMDH-Glc-CerGal-CerDH-Gal-CerSMPD1DEGS2SGMS2Sphingosine-1-phosphate1-HexadecenalPLPP3Ppap2cCoA(16:0)UGT8CoA(18:0)CoA(20:0)CoA(22:0)CoA(24:0)CoA(24:1)CoA(16:0)CoA(18:0)CoA(20:0)CoA(22:0)CoA(24:0)CoA(24:1)DH-CeramideDH-CeramideDH-CeramideDH-CeramideCERS1CERS4CERS2CoA(26:0)CoA(26:1)DH-CeramideCERS3CoA(26:0)CoA(26:1)ADPSGPP2


Description

This pathway is inspired by the Lipidmaps>Sphingolipids pathway [1].

Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules. This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide. All products are annotated with a lipid-class identifier.

The integrated pathway can be found here.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4344_107206.gpml] with a 92.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''''; , PubMed Europe PMC
  2. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S; ''Characterization of murine sphingosine-1-phosphate phosphohydrolase.''; J Biol Chem, 2002 PubMed Europe PMC
  3. Merrill AH Jr; ''De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.''; J Biol Chem, 2002 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
107602view15:21, 23 October 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-HexadecenalMetaboliteLMFA06000088 (LIPID MAPS)
3-keto-sphinganineMetaboliteLMSP01020002 (LIPID MAPS)
ADPMetaboliteCHEBI:456216 (ChEBI)
ASAH1ProteinENSG00000104763 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9WV54
ATPMetaboliteCHEBI:30616 (ChEBI)
CERKProteinENSG00000100422 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223753
CERS1ProteinENSG00000223802 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P27545
CERS2ProteinENSG00000143418 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76893
CERS3ProteinENSG00000154227 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q1A3B0
CERS4ProteinENSG00000090661 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260
CERS6ProteinENSG00000172292 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:241447
Cer-1-PMetaboliteLMSP02050000 (LIPID MAPS)
CeramideMetaboliteLMSP02010000 (LIPID MAPS)
CoA(16:0)MetaboliteLMFA07050360 (LIPID MAPS)
CoA(18:0)MetaboliteCHEBI:15541 (ChEBI)
CoA(20:0)MetaboliteCHEBI:15527 (ChEBI)
CoA(22:0)Metabolite24330-89-0 (CAS) AKA "Coenzyme A, S-​docosanoate"
CoA(24:0)Metabolite24305-30-4 (CAS) AKA "Coenzyme A, S-​(tetracosanoate)​"
CoA(24:1)Metabolite88362-35-0 (CAS) AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate"
CoA(26:0)Metabolite99313-57-2 (CAS)
CoA(26:1)Metabolite
DEGS1ProteinENSG00000143753 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13244
DEGS2ProteinENSG00000168350 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:70059
DH-Cer-1-PMetaboliteLMSP020500A0 (LIPID MAPS)
DH-CeramideMetaboliteLMSP02020000 (LIPID MAPS)
DH-Gal-CerMetabolite
DH-Glc-CerMetabolite
DH-SMMetaboliteLMSP030100A0 (LIPID MAPS)
Ethanolamine-phosphateMetabolite1015 (PubChem-compound)
Gal-CerMetaboliteLMSP0501AC00 (LIPID MAPS)
Glc-CerMetaboliteLMSP0501AA00 (LIPID MAPS)
H2OMetaboliteCHEBI:15377 (ChEBI)
HexadecanalMetaboliteLMFA06000088 (LIPID MAPS)
KDSRProteinENSG00000119537 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q6GV12
PLPP3ProteinENSG00000162407 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67916
Palmitoyl-CoAMetaboliteLMFA07050360 (LIPID MAPS) aka CoA(16:0)
Ppap2aProteinNo homologues found for original id L:19012
Ppap2cProtein
SGMS1ProteinENSG00000198964 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208449
SGMS2ProteinENSG00000164023 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74442
SGPL1ProteinENSG00000166224 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20397
SGPP1ProteinENSG00000126821 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JI99
SGPP2ProteinENSG00000163082 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q810K3
SMMetaboliteLMSP0301 (LIPID MAPS)
SMPD1ProteinENSG00000166311 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20597
SPHK1ProteinENSG00000176170 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8CI15
SPHK2ProteinENSG00000063176 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JIA7
SPTLC1ProteinENSG00000090054 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:268656
SPTLC2ProteinENSG00000100596 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P97363
SerineMetabolite5951 (PubChem-compound)
Sphinganine-1-phosphateMetaboliteLMSP01050002 (LIPID MAPS)
SphinganineMetaboliteLMSP01020001 (LIPID MAPS)
Sphingosine-1-phosphateMetaboliteLMSP01050001 (LIPID MAPS)
SphingosineMetaboliteLMSP01010001 (LIPID MAPS)
UGCGProteinENSG00000148154 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22234
UGT8ProteinENSG00000174607 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22239

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
3-keto-sphinganineSphinganinemim-conversion22642 (Rhea)
ADPmim-conversion15466 (Rhea)
ATPmim-conversion15466 (Rhea)
H2Omim-conversion27515 (Rhea)
Palmitoyl-CoA3-keto-sphinganinemim-conversion14762 (Rhea)
Sphinganine-1-phosphateSphinganinemim-conversion27515 (Rhea)
SphinganineSphinganine-1-phosphatemim-conversion15466 (Rhea)
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