Eicosanoid metabolism via Cytochrome P450 Mono-Oxygenases (CYP) pathway (Homo sapiens)

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12PPAR gammaEPHX2Arachidonic acid216-HETE17-HETE218-HETE2219-HETE20-HETE25,6-EpETrE28,9-EpETrE2211,12-EpETrE14,15-EpETrE225,6-DiHETrE8,9-DiHETrE11,12-DiHETrE14,15-DiHETrECYP2C8CYP2C8CYP2C8CYP2C18CYP4A11CYP4A22CYP4A22CYP4F12CYP4F222PPARA22


Description

This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [1] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [2]).

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[3], lipooxygenases(LOX)[4], or cytochrome P450 monooxygenases (CYP)[5]. This pathway visualises the third route, via CYP.

Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway [WP4349_106330.gpml] with a 64.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC
  2. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
107606view15:38, 23 October 2019DeSlAdded ID for PPAR Gamma.
107605view15:37, 23 October 2019DeSlRemoved proteins for where no Human ortholog is available from Mouse.
107597view15:14, 23 October 2019DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11,12-DiHETrEMetaboliteLMFA03050008 (LIPID MAPS)
11,12-EpETrEMetaboliteLMFA03090010 (LIPID MAPS)
14,15-DiHETrEMetaboliteLMFA03050010 (LIPID MAPS)
14,15-EpETrEMetaboliteLMFA03080005 (LIPID MAPS)
16-HETEMetaboliteLMFA03090010 (LIPID MAPS)
17-HETEMetaboliteLMFA03060091 (LIPID MAPS)
18-HETEMetaboliteLMFA03060092 (LIPID MAPS)
19-HETEMetaboliteLMFA03060106 (LIPID MAPS)
20-HETEMetaboliteLMFA03060009 (LIPID MAPS)
5,6-DiHETrEMetaboliteLMFA03050004 (LIPID MAPS)
5,6-EpETrEMetaboliteLMFA03080002 (LIPID MAPS)
8,9-DiHETrEMetaboliteLMFA03050006 (LIPID MAPS)
8,9-EpETrEMetaboliteLMFA03080003 (LIPID MAPS)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
CYP2C18ProteinENSG00000108242 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72082
CYP2C8ProteinENSG00000138115 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13098
CYP4A11GeneProductENSG00000187048 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
CYP4A22GeneProductENSG00000162365 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
CYP4F12GeneProductENSG00000186204 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64385
CYP4F2GeneProductENSG00000186115 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72054
EPHX2GeneProductENSG00000120915 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13850
PPAR gammaProteinP37231 (Uniprot-TrEMBL) AKA Peroxisome proliferator-activated receptor gamma
PPARAProteinENSG00000186951 (Ensembl)
  • AKA Peroxisome proliferator-activated receptor alpha
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P23204

Annotated Interactions

No annotated interactions
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