Phosphatidic Acid and Phospholipid Biosynthesis (Saccharomyces cerevisiae)

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CMPacyl-ACPS-adenosyl-homocysteine1-acyl-dihydroxyacetone-phosphateACP-SHH2Ophosphatidylcholinephosphatidyl-N-dimethylethanolaminecardiolipinS-adenosyl-L-methionineS-adenosyl-homocysteineLecithinsS-adenosyl-L-methionineL-1-phosphatidylserineCMPL-1-phosphatidylglycerol-phosphatephosphatidyl-N-methylethanolamineL-1-phosphatidyl-glycerolCO2S-adenosyl-L-methionineacyl-ACPCMPCTPglycerol-3-phosphateS-adenosyl-homocysteineACP-SHGlycerol-3-PhosphateSLC1PSD1CPT1SCT1CDP-cholineMetaboliteAYR1CRD1LPP1L-serineNADPCDS1PSD2CHO1CTPPAH1OPI3PhosphateOPI3CHO2GPT2phosphateglycerolH2ONADPHlysophosphatidic acidPGS1CDP-1,2-DiacylglycerolL-1-phosphatidyl-ethanolaminepyrophosphate1,2 diacylglycerolphosphatidic acid


Description

Chorismate is an intermediate in the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan and the vitamins, p-aminobenzoate and p-hydroxybenzoate (CITS:[Jones]). The series of reactions to chorismate, called the shikimate pathway, are common for all of the aforementioned compounds, at which point the pathway branches (CITS:[Jones][1943992]). One branch proceeds to tryptophan, one to phenylalanine and tyrosine, one to p-aminobenzoate, and one to p-hydroxybenzoate (CITS:[Jones][ 1943992]). Aromatic amino acid biosynthesis in S. cerevisiae is controlled by a combination of feedback inhibition, activation of enzyme activity, and regulation of enzyme synthesis (CITS:[Jones][1943992]). The carbon flow through the pathways is regulated primarily at the initial step and the branching points by the terminal end-products. The initial step of chorismate biosynthesis can be catalyzed by two isoenzymes, one of which (ARO3) is inhibited by phenylalanine, and the other (ARO4) by tyrosine (CITS:[Jones][1943992]). The first step in the phenylalanine-tyrosine branch is feedback inhibited by tyrosine and activated by tryptophan (CITS:[1943992]), and the first step in the tryptophan branch is feedback inhibited by tryptophan. The transcriptional activator GCN4 regulates most of the genes encoding for the aromatic amino acid biosynthetic enzymes. SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
107026view13:48, 17 September 2019MaintBotHMDB identifier normalization
89532view11:05, 16 September 2016Mkutmonontology tag fix
89489view13:39, 15 September 2016Mkutmonremove space from ontology term id
71340view18:01, 17 October 2013MaintBotAutomated update of data sources
69589view20:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67594view11:30, 26 June 2013DdiglesOntology Term : 'glycerophospholipid metabolic pathway' added !
58984view19:34, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48286view23:42, 17 May 2012KhanspersUpdating PubChem xrefs
48283view23:39, 17 May 2012MaintBotAutomatic update of PubChem xrefs
41815view04:49, 2 March 2011MaintBotRemoved redundant pathway information and comments
36636view22:35, 9 April 2010MaintBotDescription and bibliography added from SGD
34362view22:30, 9 December 2009MaintBotAutomatic update of empty xrefs
29898view12:02, 9 June 2009Thomasupdated ensembl references
27494view23:30, 2 January 2009CarolineMrejenPeriodical save, work in progress
27482view01:13, 31 December 2008CarolineMrejenPeriodical save, work in progress
27480view01:03, 31 December 2008CarolineMrejenPeriodical save, work in progress
27478view00:52, 31 December 2008CarolineMrejenPeriodical save, work in progress
27281view22:59, 23 December 2008CarolineMrejenPeriodical save, work in progress
27276view21:30, 23 December 2008CarolineMrejenPeriodical save, work in progress
27269view20:14, 23 December 2008CarolineMrejenPeriodical save, work in progress
27214view02:20, 23 December 2008CarolineMrejenPeriodical save, work in progress
27208view00:17, 23 December 2008CarolineMrejenPeriodical save, work in progress
27206view00:06, 23 December 2008CarolineMrejenPeriodical save, work in progress
27204view23:56, 22 December 2008CarolineMrejenPeriodical save, work in progress
27202view23:46, 22 December 2008CarolineMrejenPeriodical save, work in progress
27200view23:36, 22 December 2008CarolineMrejenPeriodical save, work in progress
27194view21:56, 22 December 2008CarolineMrejenPeriodical save, work in progress
27192view21:46, 22 December 2008CarolineMrejenPeriodical save, work in progress
21672view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Phosphatidic Acid and Phospholipid Biosynthesis]] moved to [[Pathway:WP472]]: Moved to stable identifier
12816view08:03, 17 May 2008MaintBotautomated metabolite conversion
8882view14:11, 7 January 2008MaintBotAdded to category $category
8880view14:11, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2 diacylglycerolMetaboliteC00641 (KEGG Compound)
AYR1GeneProductS000001386 (SGD)
CDP-1,2-DiacylglycerolMetaboliteC00269 (KEGG Compound)
CDP-cholineMetabolite987-78-0 (CAS)
CDS1GeneProductS000000233 (SGD)
CHO1GeneProductS000000828 (SGD)
CHO2GeneProductS000003389 (SGD)
CPT1GeneProductS000005074 (SGD)
CRD1GeneProductS000002301 (SGD)
CTPMetaboliteC00063 (KEGG Compound)
GPT2GeneProduct853941 (Entrez Gene)
Glycerol-3-PhosphateMetaboliteHMDB0000126 (HMDB)
H2OMetaboliteHMDB0002111 (HMDB)
L-1-phosphatidyl-ethanolamineMetabolite2644-64-6 (CAS)
L-serineMetabolite56-45-1 (CAS)
LPP1GeneProductYDR503C (Ensembl)
MetaboliteMetaboliteC03372 (KEGG Compound)
NADPHMetaboliteHMDB0000221 (HMDB)
NADPMetaboliteHMDB0000217 (HMDB)
OPI3GeneProductS000003834 (SGD)
PAH1GeneProductYMR165C (Ensembl)
PGS1GeneProductS000000510 (SGD)
PSD1GeneProductS000005113 (SGD)
PSD2GeneProductS000003402 (SGD)
PhosphateMetabolite1061 (PubChem-compound)
SCT1GeneProduct852271 (Entrez Gene)
SLC1GeneProductS000002210 (SGD)
glycerolMetabolite56-81-5 (CAS)
lysophosphatidic acidMetabolite5497152 (PubChem-compound)
phosphateMetabolite14265-44-2 (CAS)
phosphatidic acidMetabolite5287505 (PubChem-compound)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions
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